CombinedlossofproapoptoticgenesBakorBaxwithBimsynergizestocausedefectsinhematopoiesisandinthymocyteapoptosis
...ntLouisUniversitySchoolofMedicine,St.Louis,MO631042TheWalterandElizaHallInstituteofMedicalResearch,Melbourne,Victoria3050,AustraliaTheproapoptoticmembersoftheBcl-2familycanbesubdividedintomembersthatcontainseveralBcl-2homology(BH)domainsandthosethatcontainonlytheBH3domain.AlthoughitisknownthatBH3-on...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第12期InvolvementofPPARnuclearreceptorsintissueinjuryandwoundrepair
CenterforIntegrativeGenomics,NationalResearchCentre“FrontiersinGenetics,“UniversityofLausanne,Lausanne,Switzerland.AbstractTissuedamageresultingfromchemical,mechanical,andbiologicalinjury,orfrominterruptedbloodflowandreperfusion,isoftenlifethreatening.Thesubsequenttissueresponseinvolvesanintrica...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期Organ-specificrolesfortranscriptionfactorNF-Binreovirus-inducedapoptosisanddisease
...inducesapoptosisinculturedcellsandinvivo.Incellculturemodels,apoptosisiscontingentuponamechanisminvolvingreovirus-inducedactivationoftranscriptionfactorNF-Bcomplexescontainingp50andp65/RelAsubunits.ToexploretheinvivoroleofNF-Binthisprocess,wetestedthecapacityofreovirustoinduceapoptosisinmicelackinga...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期Arolefordocosahexaenoicacid–derivedneuroprotectinD1inneuralcellsurvivalandAlzheimerdisease
...er,SchoolofMedicine,NewOrleans,Louisiana,USA.2CenterforExperimentalTherapeuticsandReperfusionInjury,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,USA.AbstractDeficiencyindocosahexaenoicacid(DHA),abrain-essentialomega-3fattyacid,isassociatedwithcognitivedecline.Herewereporttha...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期Purifiedhematopoieticstemcellengraftmentofrarenichescorrectsseverelymphoiddeficiencieswithouthostconditioning
DepartmentofPathology,InstituteofCancerandStemCellBiologyandMedicine,StanfordUniversitySchoolofMedicine,Stanford,CA94305Intheabsenceofirradiationorothercytoreductiveconditioning,endogenoushematopoieticstemcells(HSCs)arethoughttofilltheuniquenicheswithinthebonemarrowthatallowmaintenanceoffullhematopo...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期TargetedablationofIKK2improvesskeletalmusclestrength,maintainsmass,andpromotesregeneration
1EuropeanMolecularBiologyLaboratory(EMBL)MouseBiologyUnit,Campus“A.Buzzati-Traverso,“Monterotondo-Scalo,Italy.2DepartmentofMouseGeneticsandInflammation,InstituteforGenetics,UniversityofCologne,Cologne,Germany.3SectionofCardiology,TulaneUniversitySchoolofMedicine,NewOrleans,Louisiana,USA.4Departm...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期pNeurotrophinReceptor-MediatedSignalingPromotesHumanHairFollicleRegression(Catagen)
【摘要】Nervegrowthfactor(NGF)anditsapoptosis-promotinglow-affinityreceptor(p75NTR)regulatemurinehaircycling.However,itisunknownwhetherhumanhairgrowthisalsocontrolledthroughp75NTR,itshigh-affinityligandpro-NGF,and/orthegrowth-promotinghigh-affinityNGFreceptortyrosinekinaseA(TrkA).Inmicrodissecte...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期TheCompositionofthe-2AdrenergicReceptorOligomerAffectsItsMembraneTraffickingafterLigand-InducedEndocytosis
...renergicreceptor(B2AR)iswellknowntoformoligomericcomplexesinvivo,butthefunctionalsignificanceofthisprocessisnotfullyunderstood.ThepresentresultsidentifyaneffectofoligomerizationofthehumanB2ARonthemembranetraffickingofreceptorsafteragonist-inducedendocytosisinstablytransfectedhumanembryonickidney293c...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第1期AdoptiveimmunotherapyinducesCNSdendriticcellrecruitmentandantigenpresentationduringclearanceofapersistentviralinfection
1MolecularandIntegrativeNeurosciencesDepartment,2DepartmentofInfectology,HaroldL.DorrisNeurologicalResearchInstitute,TheScrippsResearchInstitute,LaJolla,CA92037Giventheglobalimpactofpersistentinfectionsonthehumanpopulation,itisoftheutmostimportancetodevisestrategiestononcytopathicallypurgetissuesofi...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期BroadSpecificityofMammalianAdenylylCyclaseforInteractionwith2‘,3‘-SubstitutedPurine-andPyrimidineNucleotideInhibitors
...DepartmentMembraneadenylylcyclases(mACs)playanimportantroleinsignaltransductionandarethereforepotentialdrugtargets.Earlier,weidentified2‘,3‘-O-(N-methylanthraniloyl)(MANT)-substitutedpurinenucleotidesasanovelclassofhighlypotentcompetitivemACinhibitors(Kivaluesinthe10nMrange).MANTnucleotidesdiscr...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期