GeneticAnalysisofMeningococciCarriedbyChildrenandYoungAdults
InstituteforHygieneandMicrobiology,UniversityofWürzburg,Würzburg,GermanyPeterMedawarBuildingforPathogenResearchandDepartmentsofZoologyandStatistics,UniversityofOxford,Oxford,UnitedKingdomBackground.Neisseriameningitidisisadiversecommensalbacteriumthatoccasionallycausessevereinvasivedisease.Therela...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第8期TransactivationoftheIGF-1Rbyaldosterone
...howsaldosteronedirectlytransactivatestheIGF-1receptor(IGF-1R).InA6cells,10-minexposuretoaldosteroneincreasedthephosphorylationoftheIGF-1receptor,insulinreceptorsubstrate-1(IRS-1),andAkt(PKB).Furthermore,aldosteroneactivatedPI3-Kandphosphorylationofthemostdownstreamelement,Akt,wasblockedbythespecific...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第4期Microbialmodulationofinnatedefense:gobletcellsandtheintestinalmucuslayer
...na,IL61801.E-mail:hgaskins{at}uiuc.edu.ABSTRACTThegastrointestinalepitheliumiscoveredbyaprotectivemucusgelcomposedpredominantlyofmucinglyco-proteinsthataresynthesizedandsecretedbygobletcells.Changesingobletcellfunctionsandinthechemicalcompositionofintestinalmucusaredetectedinresponsetoabroadrangeofl...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第6期RegulationofSTIM1,store-operatedCa2+influx,andnitricoxidegenerationbyretinoicacidinratmesangialcells
...argelyunknown.Inthecurrentstudy,weusedprimaryculturedratmesangialcellstoexaminetheeffectofRAonSOCandSTIM1.Inthesecells,BKcausedconcentration-dependent[Ca2+]imobilization.TreatmentofthecellswithRA,whileithadnoeffectontheinitialpeak,reducedtheplateauphaseofBK-mediated[Ca2+]iresponse,indicatingtheinhib...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第3期Interferon-PlaysProtectiveRolesinSodiumArsenite-InducedRenalInjurybyUp-RegulatingIntrarenalMultidrugResistance-AssociatedProteinExpression
【摘要】Subcutaneousinjectionofsodiumarsenite(NaAs,12.5mg/kg)intoBALB/cmicecausesacuterenaldysfunctioncharacterizedbyseverehemorrhages,acutetubularnecrosis,andcastformation,withincreasesinserumbloodureanitrogenandcreatininelevels.Concomitantenhancementinintrarenalinterferon(IFN)-expressionprompt...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期AnewtypeofradiosensitiveT–B–NK+severecombinedimmunodeficiencycausedbyaLIG4mutation
...nsitivetoionizingradiation,andthemajorityofthesepatientshavemutationsinArtemis.WepresentapatientwithanewtypeofradiosensitiveT–B–NK+SCIDwithadefectinDNAligaseIV(LIG4).Todate,LIG4mutationshaveonlybeendescribedinaradiosensitiveleukemiapatientandin4patientswithadesignatedLIG4syndrome,whichisassociat...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期AtestofOckhamsrazor:implicationsofconjugatedlinoleicacidinbonebiology
...ippman,SusanReinwaldandMarkFSeifert1FromtheDepartmentofFoodScience,LipidChemistryandMolecularBiologyLaboratory,PurdueUniversity,WestLafayette,IN(BAW,YL,HEL,andSR),andtheDepartmentofAnatomyandCellBiology,IndianaUniversitySchoolofMedicine,Indianapolis(BAWandMFS)2Presentedattheworkshop“TheRoleofConju...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第6期Overexpressionofangiotensintype2receptoramelioratesglomerularinjuryinamouseremnantkidneymodel
...liferationbycounteractingtheactionsofAT1R.TheaimofthepresentstudywastodeterminetheeffectofAT2Roverexpressiononglomerularinjuryinducedbynephrectomy(Nx).AT2Rtransgenicmice(AT2-Tg),overexpressingAT2Runderthecontrolof-smoothmuscleactin(-SMA)promoter,andcontrolwild-typemice(Wild)weresubjectedtoNx.InAT2-T...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第3期NigrostriatalDamagePreferentiallyDecreasesaSubpopulationof62*nAChRsinMouse,Monkey,andParkinson‘sDiseaseStriatum
...aneurodegenerativemovementdisordercharacterizedbyalossofsubstantianigradopamineneurons,andcorrespondingdeclinesinmolecularcomponentspresentonstriataldopaminergicnerveterminals.Theseincludethe62*nicotinicacetylcholinereceptors(nAChRs),whicharelocalizedexclusivelyondopamineterminalsinstriatum(*denotes...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期Protease-ActivatedReceptor-Activation
...serineproteaseinhibitors.FluidscollectedfromchambersofP.gingivalis-injectedmicewereabletoactivatePAR2andthisactivationwasinhibitedbyserineproteaseinhibitors.P.gingivalisinoculationintosubcutaneouschambersofwild-typemiceinducedaninflammatoryresponsethatwasinhibitedbyaserineproteaseinhibitorandwassign...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期