ForcedusageofpositivelychargedaminoacidsinimmunoglobulinCDR-H3impairsBcelldevelopmentandantibodyproduction
...iology,DepartmentofPediatrics,DepartmentofMedicine,DepartmentofPediatricDentistry,andDepartmentofGenetics,UniversityofAlabamaatBirmingham,SHEL401,Birmingham,AL352942DepartmentofGenetics,UniversityofErlangen,91058Erlangen,Germany3DepartmentofClinicalMicrobiology,UniversityofKuopio,POB1627,70211Kuopio...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第6期AttenuatedliverfibrosisintheabsenceofBcells
1ImmunologyDepartment,BiogenIdec,Cambridge,Massachusetts,USA.2TheCBRInstituteforBiomedicalResearch,HarvardMedicalSchool,Boston,Massachusetts,USA.3DepartmentofLaboratoryMedicineandSectionofImmunobiology,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,USA.AbstractAnalysisofmononuclearcellsintheadu...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第11期BAGDeficiencyResultsinFulminantMyopathyandEarlyLethality
...Bcl-2-associatedathanogene3(BAG3)isamemberofaconservedfamilyofcyto-protectiveproteinsthatbindtoandregulateHsp70familymolecularchaperones.Here,weshowthatBAG3isprominentlyexpressedinstriatedmuscleandcolocalizeswithZ-disks.Micewithhomozygousdisruptionofthebag3genedevelopednormallybutdeterioratedpostnat...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期AThree-DimensionalQuantitativeStructure-ActivityAnalysisofaNewClassofBisphenolTopoisomeraseIIInhibitors
【关键词】Three-DimensionalAftertheidentificationofanewleadbisphenolcompoundthathadgoodtopoisomeraseII(EC5.99.1.3)inhibitoryactivity,aseriesofbisphenolanalogsweresynthesizedandtestedtoidentifythestructuralfeaturesthatwereresponsiblefortheiractivity.Thebisphenolsrepresentanewstructuralclassoftop...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期TheRetC0RMutationAffectsRenalandEntericDevelopmentinaMouseModelofHirschsprung??sDisease
【摘要】InrarefamiliesRETtyrosinekinasereceptorsubstitutionslocatedinexon10(especiallyatpositions609,618,and620)canconcomitantlycausetheMEN2A(multipleendocrineneoplasiatype2A)orFMTC(familialmedullarythyroidcarcinoma)cancersyndromes,andHirschsprung??sdisease(HSCR).Noanimalmodelmimickingtheco-exis...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期GolgiFragmentationandCellDeathfromOverexpressionofWild-TypeandMutantOptineurininTwoOcularCellTypes
【摘要】Optineurin(OPTN)hasrecentlybeenlinkedtoglaucoma,amajorcauseofblindnessworldwide.MutationsinOPTNsuchasGlu50Lys(E50K)havebeenreportedinpatients,particularlythosewithnormalpressureglaucoma.Here,weshowthattheendogenousOPTNwasnotsecretedintwoocularcelltypes,humantrabecularmeshworkandretinalpi...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期AQP7islocalizedincapillariesofadiposetissue,cardiacandstriatedmuscle:implicationsinglycerolmetabolism
...ulesandisinvolvedinglyceroluptake.Thecellularexpressionandphysiologicalfunctioninotherorgansremainlargelyundefined.AQP7knockout(KO)miceweregeneratedandusedforimmunohistochemicalanalysestodefinetheorganandcellularexpressionofAQP7.AQP7labelingwasfoundinkidneyproximaltubule,heart,skeletalmuscle,testis,...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第3期CharacterizationofaNewSpeciesofAdenovirusinFalcons
ZoologicalSocietyofSanDiego,CenterforReproductionofEndangeredSpecies,DepartmentofPathology,MolecularDiagnosticsLaboratory,P.O.Box120-551,SanDiego,California92112DepartmentofVeterinaryMicrobiologyandPathology,WashingtonStateUniversity,Pullman,Washington99164-7040CollegeofVeterinaryMedicine,University...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第7期NeurotoxicityofDomoicAcidinCerebellarGranuleNeuronsinaGeneticModelofGlutathioneDeficiency
【关键词】NeurotoxicityThisstudyinvestigatedtheroleofcellularantioxidantdefensemechanismsinmodulatingtheneurotoxicityofdomoicacid(DomA),byusingcerebellargranuleneurons(CGNs)frommicelackingthemodifiersubunitofglutamate-cysteineligase(Gclm).Glutamate-cysteineligase(Glc)catalyzesthefirstandrate-li...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期EndogenoushumancytomegalovirusgBispresentedefficientlybyMHCclassIImoleculestoCD4+CTL
...biologyandImmunology,VeteransAffairsMedicalCenter2DivisionofPulmonaryandCriticalCareMedicine,VeteransAffairsMedicalCenter3VaccineandGeneTherapyInstitute,OregonHealthScienceUniversity,Portland,OR97239Humancytomegalovirus(HCMV)infectsendothelial,epithelial,andglialcellsinvivo.ThesecellscanexpressMHCcl...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第8期