pCipProtectionagainstHyperoxiaRequiresBcl-XLandIsUncoupledfromItsAbilitytoSuppressGrowth
...21doesnotleadtoaberrantcellproliferation.BecausesomemembersoftheBcl-2genefamilyhavebeenimplicatedinhyperoxia-inducedcelldeath,thecurrentstudyinvestigatedtheirexpressionaswellasp21-dependentgrowthsuppressionandcytoprotection.Conditionaloverexpressionoffull-lengthp21,itsamino-terminalcyclin-binding(p2...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期Selectivedepletionofmacrophagesrevealsdistinct,opposingrolesduringliverinjuryandrepair
...g.SeetherelatedCommentarybeginningonpage29IntroductionMacrophagesfeatureprominentlyatdiversesitesofinflammationandhavebeenlinkedtotheprocessofinflammationandrepair,demonstratingarepertoireofactivitiesthatincluderegulatinginflammatorycells,tissuedebridement,cellkilling,recruitingandactivatingmyofibro...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第1期AnessentialroleforcomplementC5ainthepathogenesisofsepticcardiacdysfunction
...thology,DepartmentofSurgery,andDepartmentofInternalMedicine,TheUniversityofMichiganMedicalSchool,AnnArbor,MI48109Defectivecardiacfunctionduringsepsishasbeenreferredtoas“cardiomyopathyofsepsis.“Itisknownthatsepsisleadstointensiveactivationofthecomplementsystem.Inthecurrentstudy,cardiacfunctionand...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期RasGRP1ConfersthePhorbolEster-SensitivePhenotypetoEL4LymphomaCells
...erphorbol12-myristate13-acetate(PMA).InsensitiveEL4cells,PMAcausesrobustErkmitogen-activatedproteinkinaseactivationthatresultsingrowtharrest.Inresistantcells,PMAinducesminimalErkactivation,withoutgrowtharrest.PMAstimulatesIL-2productioninsensitive,butnotresistant,cells.TheroleofRasGRP1,aPMA-activate...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期Autoantigen,innateimmunity,andTcellscooperatetobreakBcelltoleranceduringbacterialinfection
...RFs.Surprisingly,thisproductionwasmorepronouncedinintermediate-affinityRFTgmicecoexpressingtheautoantigen.ThisoverproductionwasmediatedbyimmunecomplexesandinvolvedsynergisticsignalingbetweentheBcellreceptorandToll-likereceptorsandTcellhelp.Thesefindingsindicatethatchronicinfectioncanactivateautoreac...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期DevelopmentofImmunoglobulinANephropathy-LikeDiseaseinß--Galactosyltransferase-I-DeficientMice
...evealedthataberrantglycosylationcausesvarioushumandiseases.Herewereportthatmicelackingß-1,4-galactosyltransferase(ß4GalT)-I,whichtransfersgalactosetotheterminalN-acetylglucosamineofN-andO-linkedglycansinaß-1,4linkage,spontaneouslydevelopedhumanimmunoglobulinAnephropathy(IgAN)-likeg...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期PopulationStructureandPropertiesofCandidaalbicans,asDeterminedbyMultilocusSequenceTyping
...artmentofZoology,UniversityofOxford,OX13SYOxford,UnitedKingdomABSTRACTWesubmittedapanelof416isolatesofCandidaalbicansfromseparatesourcestomultilocussequencetyping(MLST).Thedatagenerateddeterminedapopulationstructureinwhichfourmajorcladesofcloselyrelatedisolatesweredelineated,togetherwitheightminorcl...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期ShigatoxintriggersthromboticthrombocytopenicpurpuraingeneticallysusceptibleADAMTS13-deficientmice
1DepartmentofPediatrics,UniversityofMichigan,AnnArbor,Michigan,USA.2CBRInstituteforBiomedicalResearch,Boston,Massachusetts,USA.3DepartmentofPathology,HarvardMedicalSchool,Boston,Massachusetts,USA.4DepartmentofPathologyand5DepartmentofHumanGenetics,UniversityofMichigan,AnnArbor,Michigan,USA.6Departme...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期ImmunomodulatoryEffectofCombinationTherapywithLovastatinand-Aminoimidazole--Carboxamide--ß-D-RibofuranosideAlleviatesNeurodegenerationinExpe
...uneresponsefromTh1toaprotectiveTh2responseinEAEbyadifferentmechanismthan5-aminoimidazole-4-carboxamide-1-ß-D-ribofuranoside,animmunomodulatingagentthatactivatesAMP-activatedproteinkinase.HerewetestedtheseagentsincombinationinanEAEmodelofMS.Suboptimaldosesofthesedrugsincombinationwereadditivein...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期BasolateralK+conductanceinprincipalcellsofratCCD
...CornellUniversity,NewYork,NewYorkABSTRACTWholecellK+currentwasmeasuredbyformingsealsontheluminalmembraneofprincipalcellsinsplit-openratcorticalcollectingducts.Themeaninward,Ba2+-sensitiveconductance,with40mMextracellularK+,was76±12and141±22nS/cellforanimalsoncontrolandhigh-K+diets,respectively.The...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第3期