ContrastingRolesforAxonalDegenerationinanAutoimmuneversusViralModelofMultipleSclerosis
...smurineencephalomyelitisvirus(TMEV)infection.Wecomparedwild-typeC57BL/6(B6)micewithC57BL/Wlds(Wld)mice,whichcarryamutationthatdelaysaxonaldegeneration.InEAE,bothmousestrainsweresensitizedwithmyelinoligodendrocyteglycoprotein(MOG)35-55peptideandshowedasimilardiseaseonset,MOG-specificlymphoproliferati...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期MechanismofThiazolidinedione-DependentCellDeathinJurkatTCells
...ewmechanismtoaccountforthiazolidinedione-initiatedbutPPAR-independentcelldemise.InJurkatTcells,ciglitazoneandtroglitazoneprovokedrapidanddose-dependentcelldeath,whereasrosiglitazonedidnotaltercellviability.Wefoundinductionofapoptosisbytroglitazone,whereasciglitazonecausednecrosis.Becausepreincubatio...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期MastCell-DerivedTumorNecrosisFactorCanPromoteNerveFiberElongationintheSkinduringContactHypersensitivityinMice
...notfullyunderstood.Wefoundthatcontacthypersensitivityreactionstooxazoloneinmicewereassociatedwithsignificantincreasesinthelengthofnervesintheepidermisanddermis.Usinggeneticallymastcell-deficientc-kitmutantmiceselectivelyrepairedoftheirdermalmastcelldeficiencywitheitherwild-typeortumornecrosisfactor(...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期DelineationofMatriptaseProteinExpressionbyEnzymaticGeneTrappingSuggestsDivergingRolesinBarrierFunctionHairFormationandSquamousCellCarcinog
...requiredforepidermalbarrierfunction,hairformation,andthymocytedevelopmentinmice,anddysregulatedmatriptaseexpressioncausesepidermalsquamouscellcarcinoma.Toelucidatethespecificfunctionsofmatriptaseinnormalandaberrantepidermaldifferentiation,weusedenzymaticgenetrappingcombinedwithimmunohistochemical,ul...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第5期TheUnusualState-DependentAffinityofP2X3ReceptorsCanBeExplainedbyanAllostericTwo-Open-StateModel
...bilityofP2X3receptorsformediatingpainsensation.ThesereceptorsareactivatedbymicromolarATP,butnanomolarATPissufficienttoeffectivelydesensitizethem.ThemechanismbehindHADisstillobscure.Ithasbeensuggested(JNeurosci25:7359-7365,2005[Abstract/FreeFullText])thatHADcanhappenonlyifthereceptorhaspreviouslybeen...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期p38MAPK/HSP25signalingmediatescadmium-inducedcontractionofmesangialcellsandrenalglomeruli
【关键词】cadmium-inducedDepartmentofCellandDevelopmentalBiology,andDepartmentofPediatricsandCommunicableDiseases,UniversityofMichiganMedicalSchool,AnnArborToxicologyProgram,DepartmentofEnvironmentalHealthSciences,SchoolofPublicHealth,UniversityofMichigan,AnnArbor,MichiganMolecularSignalingGrou...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第6期TheSchistosomamansoniHepaticEggGranulomaProvidesaFavorableMicroenvironmentforSustainedGrowthofLeishmaniadonovani
...thesameorgan.Wehavestudiedthisusinganexperimentalco-infectionmodelinC57BL/6miceinvolvingSchistosomamansoniandLeishmaniadonovani,twoimportanthumanpathogensaffectingtheliver.WeshowthatmicewithestablishedS.mansoniinfectionsfailtocontrolL.donovanigrowthintheliverandspleen.Thefailureoccursdespitethedevel...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期ArylHydrocarbonReceptorSpliceVariantsintheDioxin-ResistantRat:TissueExpressionandTransactivationalActivity
...atorofmultipledrug-metabolizingenzymesandmediatoroftoxicityofdioxin-likechemicals.TheHan/Wistar(Kuopio)ratstrain(H/W)isremarkablyresistanttolethaleffectsof2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)becauseofapointmutationintheexon/intron10boundaryinAHRgenomicstructurethatleadstouseof3alternativecrypti...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期OrphaninFQ/NociceptinPotentiates[D-Ala2,N-Me-Phe4,Gly5-ol]-EnkephalineCInducedeOpioidReceptorPhosphorylation
...astomacellstransfectedwithepitope-taggede?receptors.OFQ/Ntreatment(100nM,60min)potentiatedDAMGO-inducede?receptorphosphorylation;inhibitionofGRK2orproteinkinaseCconcomitantwithOFQ/NtreatmentblockedtheOFQ/N-mediatedincreaseinDAMGO-inducedphosphorylation.InclusionoftheNOPantagonistpeptideIII-BTDduring...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期常用试剂配制-3
Thefollowingisalistofthesolutionsandchemicalsrequiredthroughoutthelaboratorymanual.Itisorganizedalphabetically,andindividualexerciseslistthematerialsneededforthatexercise.Formanysolutions,directionsaregivenforamolarsolutionandtheuserislefttodilutetotheappropriateconcentrationfortheirneeds.Therearema...
药品天地;专业药学;实验技术;基本实验技术;常用试剂