SelectivetargetingofregulatoryTcellswithCD28superagonistsallowseffectivetherapyofexperimentalautoimmuneencephalomyelitis
1InstituteforVirologyandImmunobiology,UniversityofWürzburg2DepartmentofNeurology,UniversityHospitalWürzburg,D-97078Würzburg,Germany3TeGeneroImmunoTherapeuticsAG,D-97076Würzburg,Germany4InstituteforMSResearch,UniversityofGttingenandGemeinnützigeHertieStiftung,D-37073Gttingen,GermanyCD4+CD25+regu...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第3期ActivatingProtein1-MediatedCyclooxygenase-2ExpressionIsIndependentofN-TerminalPhosphorylationofc-Jun
DepartmentofPharmacology,CollegeofMedicine,NationalChengKungUniversity,Tainan,TaiwanAbstractTranscriptionalactivationofthecyclooxygenase(COX)-2geneisresponsibleforhighlevelofprostaglandinproductionduringinflammationandcarcinogenesis.Wefoundpreviouslythatc-Juninductionplaysacrucialroleinepidermalgrow...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期PreventionofPlateletGlycoproteinIIb/IIIaActivationby3,4-Methylenedioxy-β-Nitrostyrene,ANovelTyrosineKinaseInhibitor
【关键词】PreventionBindingfibrinogentoactivatedglycoprotein(GP)IIb/IIIaisthefinalcommonpathwayofplateletaggregationandhasbecomeasuccessfultargetforantiplatelettherapy.Inthepresentstudy,wefoundthatasmallchemicalcompound,3,4-methyl-enedioxy-β-nitrostyrene(MNS),exhibitedpotentandbroad-spectr...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期CharacterizationoftheregulationofrenalNa+/H+exchangerNHE3byinsulin
【摘要】Insulinreceptorsarewidelydistributedinthekidneyandaffectmultipleaspectsofrenalfunction.Intheproximaltubule,insulinregulatesvolumeandacid-baseregulationthroughstimulationoftheNa+/H+exchangerNHE3.ThispapercharacterizesthesignalingpathwaybywhichinsulinstimulatesNHE3inacellculturemodel[oposs...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期AdrenomedullinStimulatesNitricOxideProductionfromPrimaryRatHypothalamicNeurons:RolesofCalciumandPhosphatases
...gestedthatnitricoxide(NO)mediatesADM‘seffectsinthebrain,mechanismsforADMstimulationofNOproductioninneuronshavenotbeenidentified.Inthepresentstudy,primaryhypothalamicneuronswereusedtocharacterizeADM-inducedNOproductionandtostudytheunderlyingmechanisms.UsingCalciumOrange/4-amino-5-methylamino-2‘,7...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期TheTelomericProteinTRF2IsCriticalfortheProtectionofA549CellsfromBothTelomereErosionandDNADouble-StrandBreaksDrivenbySalvicine
...remainstobeclarifiedwhethertheyshareacommonresponsetothesetwoeventsandinparticularwhetherTRF2isinvolvedinthisprocess.Inthisstudy,wefoundthatSALconcurrentlyinducedDNAdouble-strandbreaks,telomericDNAdamage,andtelomereerosioninlungcarcinomaA549cells.ItwasunexpectedtofindthatSALledtodisruptionofTRF2,ind...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期Physiologicalpathwayofdifferentiationofhematopoieticstemcellpopulationintomuralcells
1DepartmentofStemCellBiology,CancerResearchInstitute,KanazawaUniversity,Kanazawa920-0934,Japan2PRESTO,JapanScienceTechnologyAgency,Saitama332-0012,JapanEndothelialcells(ECs),whichareamajorcomponentofbloodvessels,havebeenreportedtodevelopinadulthoodfromhematopoieticcellpopulations,especiallythoseofth...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期CellulardistributionofthepotassiumchannelKCNQ1innormalmousekidney
【摘要】MechanismsofK+secretionandabsorptionalongthecollectingductarenotunderstoodfully.BecauseKCNQ1participatesinK+secretionwithintheinnerearandstomach,distributionofKCNQ1inmousekidneywasstudiedusingNorthernandWesternanalyses,RT-PCRofisolatedtubules,andimmunohistochemistry.Northernblotsdemonstr...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期AProteinToxinfromtheSeaAnemonePhyllodiscussemoniTargetstheKidneyandCausesaSevereRenalInjurywithPredominantGlomerularEndothelialDamage
【摘要】EnvenomationbytheseaanemonePhyllodiscussemonicausesfulminantdermatitisand,rarely,acuterenalfailureinhumans.Here,weinvestigatedwhetherthevenomextractedfromthenematocysts(PsTX-T)wasnephrotoxicwhenadministeredintravenouslyinratsandwhetherPsTX-Tinducedactivationofthecomplementsystem.Although...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期SURFINisapolymorphicantigenexpressedonPlasmodiumfalciparummerozoitesandinfectederythrocytes
1MicrobiologyandTumorbiologyCenter,KarolinskaInstitutet,SE-17177Stockholm,Sweden2DepartmentofTropicalMedicineandParasitology,DokkyoUniversitySchoolofMedicine,Tochigi321-0293,Japan3DepartmentofMolecularParasitology,EhimeUniversitySchoolofMedicine,Ehime791-0295,Japan4ResearchInstitute,InternationalMed...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第11期