SubstrateinteractionsinthehumantypeIIasodium-phosphatecotransporter(NaPi-IIa)
【关键词】humanInstituteofPhysiology,UniversityofZurich,Zurich,SwitzerlandABSTRACTWehavecharacterizedthekineticsofsubstratetransportintherenaltypeIIahumansodium-phosphatecotransporter(NaPi-IIa).ThetransporterwasexpressedinXenopuslaevisoocytes,andsteady-stateandpre-steady-statecurrentsandsubstra...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第5期RoleofNuclearFactor-BandProteinKinaseCSignalingintheExpressionoftheKininB1ReceptorinHumanVascularSmoothMuscleCells
...aracterizedinhumanumbilicalarterysmoothmusclecellstofurtherelucidatethefunctionandspecificityofthreepreviouslyproposedpathways[nuclearfactor-B(NF-B),proteinkinaseC,andagonistautoregulation]thatregulatethisinducibleGprotein-coupledreceptor.Radioligandbindingassays,real-timereversertranscription/polym...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期Geneticcausesofhumanheartfailure
DepartmentofGenetics,HarvardMedicalSchool,DivisionofCardiology,BrighamandWomen’sHospital,andHowardHughesMedicalInstitute,Boston,Massachusetts,USA.AbstractFactorsthatrenderpatientswithcardiovasculardiseaseathighriskforheartfailureremainincompletelydefined.Recentinsightsintomoleculargeneticcausesofm...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期Autoantigen,innateimmunity,andTcellscooperatetobreakBcelltoleranceduringbacterialinfection
...iologie,H?pitauxUniversitairesdeStrasbourg,Strasbourg,France.AbstractAutoantibodyproductionduringinfectionsisconsideredtoresultfromnonspecificactivationoflow-affinityautoreactiveBcells.Whetherthiscanleadtoautoimmunediseaseremainsuncertain.WeshowthatchronicinfectionbyBorreliaburgdorferiofTganimalsexp...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期HypoxicSwitchinMitochondrialMyeloidCellLeukemiaFactor-/MtdApoptoticRheostatContributestoHumanTrophoblastCellDeathinPreeclampsia
...eathandalteredtrophoblast-mediatedremodelingofmyometrialspiralarteriesresultinginreduceduteroplacentalperfusion.Mitochondria-associatedBcl-2familymembersareimportantregulatorsofprogramedcelldeath.Themechanismwherebyhypoxiaaltersthemitochondrialapoptoticrheostatisessentialtoourunderstandingofplacenta...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期LithiumactivatestheWntandphosphatidylinositol3-kinaseAktsignalingpathwaystopromotecellsurvivalintheabsenceofsolublesurvivalfactors
【关键词】LithiumRenalSection,BostonMedicalCenter,BostonUniversitySchoolofMedicine,Boston,MassachusettsSectionofNephrology,UniversityofIllinoisatChicago,Chicago,IllinoisABSTRACTMouseproximaltubularcells(BUMPT),whenculturedintheabsenceofgrowthfactors,activateadefaultapoptoticpathway.AlthoughWnts...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期FasLandTRAILInduceEpidermalApoptosisandSkinUlcerationUponExposuretoLeishmaniamajor
...摘要】Receptor-mediatedapoptosisisproposedasanimportantregulatorofkeratinocytehomeostasisinhumanepidermis.WehavepreviouslyreportedthatFas/FasLinteractionsinepidermisarealteredduringcutaneousleishmaniasis(CL)andthatkeratinocytedeaththroughapoptosismayplayapathogenicroleforskinulceration.Tofurtheri...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期LiverXReceptor(LXR)-βRegulationinLXR-DeficientMice:ImplicationsforTherapeuticTargeting
...】(LXR)-βThenuclearreceptorsliverXreceptor(LXR)LXRandLXRβaredifferentiallyexpressedligand-activatedtranscriptionfactorsthatinducegenescontrollingcholesterolhomeostasisandlipogenesis.SyntheticligandsforbothreceptorsubtypesactivateATPbindingcassettetransporterA1(ABCA1)-mediatedcholesterolmetabo...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期AbsenceofbacteriallyinducedRELM?reducesinjuryinthedextransodiumsulfatemodelofcolitis
...hiladelphia,Pennsylvania,USA.2DivisionofGastroenterology,HepatologyandNutrition,TheChildren’sHospitalofPhiladelphia,Philadelphia,Pennsylvania,USA.3DivisionofPulmonaryAllergyandCriticalCareand4DivisionofEndocrinology,Diabetes,andMetabolism,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Penns...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期InductionofApoptosisbyVinblastineviac-JunAutoamplificationandp53-IndependentDown-Regulationofp21WAF1/CIP1
【关键词】InductionVinblastinetreatmentinallcelllinesexaminedcausesarobustincreaseinc-Junproteinexpressionandphosphorylationandacorrespondingincreaseinactivatorprotein-1(AP-1)transcriptionalactivity.WeshowinKB-3carcinomacellsthatthisisduetoastrongautoamplificationloopinvolvingtheproximalAP-1sit...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期