Wild-TypeApoA-IandtheMilanoVariantHaveSimilarAbilitiestoStimulateCellularLipidMobilizationandEfflux
...igationofcellularlipidmobilizationandeffluxtolipid-freehumanapoA-IandapoA-IMilano,reconstitutedhigh-densitylipoprotein(rHDL)particlescontainingtheseproteinsandserumisolatedfrommiceexpressinghumanapoA-IorapoA-IMilano.MethodsandResults—Cholesterolandphospholipideffluxtotheseacceptorswasmeasuredi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第9期AlteredexpressionofCOX-1,COX-2,andmPGESinratswithnephrogenicandcentraldiabetesinsipidus
...ana,SloveniaInstituteofAnatomy,UniversityofAarhus,AarhusCDepartmentofBiochemistryandCellBiology,SchoolofMedicine,KyungpookNationalUniversity,Taegu,KoreaInstituteofExperimentalClinicalResearch,UniversityofAarhus,AarhusN,DenmarkABSTRACTProstaglandinshaveanimportantroleinrenalsaltandwaterreabsorption.P...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第5期NeuronalapoptosisinhibitoryproteinisexpressedindevelopingkidneyandisregulatedbyPAX
...Duringfetalkidneydevelopment,theextentofuretericbud(UB)branchingwilldeterminefinalnephronendowmentforlife.Nephronnumbervarieswidelyamongnormalhumansandthosewhoarebornatthelowendofthenephronnumberspectrummaybeatriskforessentialhypertensioninadulthood.Littleisknownabouthownephronnumberisset.However,we...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第10期ProteochemometricMappingoftheInteractionofOrganicCompoundswithMelanocortinReceptorSubtypes
...tsfromthreeoftheMC1,3-5receptors.Thebindingaffinitiesof18compoundsweredeterminedforthesechimericmelanocortinreceptorsandthefourwild-typemelanocortinreceptors.Thedatafor14ofthesecompoundswerecorrelatedtothephysicochemicalandstructuraldescriptorsofcompounds,binarydescriptorsofreceptorsequences,andcros...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第1期CharacterizationofNicotinicAcetylcholineReceptorsThatModulateNicotine-Evoked[3H]NorepinephrineReleasefromMouseHippocampalSynaptosomes
...CharacterizationNicotine‘smodulationofhippocampalnoradrenergicneurotransmissionmaycontributetoitsmnemonicproperties,butthenicotinicacetylcholinereceptor(nAChR)subtypesthatmodulateterminalreleaseofnorepinephrineareunknown.Inthepresentstudy,weusedanumberofsubtype-selective-conotoxinsincombinationwit...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期IdentificationofSmall-MoleculeInhibitorsofRGS4UsingaHigh-ThroughputFlowCytometryProteinInteractionAssay
...allybeendifficult.TheaimofthisprojectwastoidentifyinhibitorsofRGS4.UsingaLuminex96-wellplatebeadanalyzerandanovelflow-cytometricproteininteractionassaytoassessG-RGSinteractionsinahigh-throughputscreen,weidentifiedthefirstsmall-moleculeinhibitorofanRGSprotein.Of3028compoundsscreened,1,methylN-[(4-chl...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期Ischemia-inducedcleavageofcadherinsinNRKcellsrequiresMT1-MMP(MMP-14)
...geofVeterinaryMedicine,TexasA&MUniversity,CollegeStation,TexasABSTRACTIschemiaisaleadingcauseofacuterenalfailure(ARF),adiseaseassociatedwithhighmorbidityandmortality.DisruptionofintercellularadhesionintheproximaltubulesislinkedtoARF,althoughthemolecularmechanism(s)remainsunclear.Ourpreviousstudiessh...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第1期MllpartialtandemduplicationinducesaberrantHoxexpressioninvivoviaspecificepigeneticalterations
...University,Columbus,Ohio,USA.AbstractWepreviouslyidentifiedarearrangementofmixed-lineageleukemia(MLL)gene(alsoknownasALL-1,HRX,andHTRX1),consistingofanin-framepartialtandemduplication(PTD)ofexons5through11intheabsenceofapartnergene,occurringinapproximately4%–7%ofpatientswithacutemyeloidleukemia(AM...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期DifferentialantitumorimmunitymediatedbyNKTcellsubsetsinvivo
1DepartmentofMicrobiologyandImmunology,UniversityofMelbourne,Melbourne,Victoria3010,Australia2CancerImmunologyProgram,PeterMacCallumCancerCentre,Melbourne,Victoria3002,AustraliaWeshowedpreviouslythatNKTcell–deficientTCRJ18–/–micearemoresusceptibletomethylcholanthrene(MCA)-inducedsarcomas,andth...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第9期ReversionofStructure-ActivityRelationshipsofAntitumorPlatinumComplexesbyAcetoximebutNotHydroxylamineLigands
...chlorobis(acetoxime)platinum(II)][2(trans)],aswellasthoseof[PtCl2(hydroxylamine)2],cis-[dichlorobis(hydroxylamine)platinum(II)][3(cis)]andtrans-[dichlorobis(hydroxylamine)platinum(II)][4(trans)].Wefoundthat2(trans)is16timesmorecytotoxicthan1(cis)andascytotoxicascisplatinincisplatin-sensitiveovarianc...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期