AberrantExpressionofIDaSuppressorofB-Cell-SpecificGeneExpressioninHodgkin??sLymphoma
【摘要】ThegloballossofB-cell-specificgeneexpressionisadistinctivefeatureoftheHodgkin-Reed/Sternberg(HRS)cellsofclassicalHodgkin??slymphoma(HL).ThereasonsforthislossremainedlargelyunknownastranscriptionfactorswithpleiotropiceffectsonB-cell-specificgeneexpression,namelyE2A,EBF,andPAX5,arepresenti...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期Salt-sensitivehypertensionisassociatedwithdysfunctionalCyp4a10geneandkidneyepithelialsodiumchannel
...ry,UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,USA.AbstractFunctionalandbiochemicaldatahavesuggestedaroleforthecytochromeP450arachidonatemonooxygenasesinthepathophysiologyofhypertension,aleadingcauseofcardiovascular,cerebral,andrenalmorbidityandmortality.Weshowherethatdisruptionofthemuri...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期TheSchistosomamansoniHepaticEggGranulomaProvidesaFavorableMicroenvironmentforSustainedGrowthofLeishmaniadonovani
【摘要】Parasiticco-infectionsareprevalentinmanypartsoftheworld.However,relativelylittleisknownabouthowanunderlyinginfectionmayimpactonthehost??sabilitytocontrolanewlyacquiredparasite,especiallyifbothinfectthesameorgan.Wehavestudiedthisusinganexperimentalco-infectionmodelinC57BL/6miceinvolvingSc...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期LocalInsP3-dependentperinuclearCa2+signalingincardiacmyocyteexcitation-transcriptioncoupling
...a,California,USA.3MyogenInc.,Westminster,Colorado,USA.4UniversityofCincinnati,Cincinnati,Ohio,USA.5UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,USA.AbstractPreviousworkshowedthatcalmodulin(CaM)andCa2+-CaM–dependentproteinkinaseII(CaMKII)aresomehowinvolvedincardiachypertrophicsignaling,t...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期-Tocopherol,themajorformofvitaminEintheUSdiet,deservesmoreattention
...fMolecularandCellBiology,Berkeley;theChildren‘sHospitalOaklandResearchInstitute,Oakland,CA;andtheInstituteforInfectiousDiseases,UniversityofBerne,Berne,Switzerland.2SupportedbyaPostdoctoralFellowshipfromtheAmericanHeartAssociationWesternAffiliates(grant98-24toQJ);theSwissNationalScienceFound...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第6期EnhancedGlucocorticoidReceptorSignalinginTCellsImpactsThymocyteApoptosisandAdaptiveImmuneResponses
【摘要】TostudytheeffectofenhancedglucocorticoidsignalingonTcells,wegeneratedtransgenicratsoverexpressingamutantglucocorticoidreceptorwithincreasedligandaffinityinthethymus.Wefoundthatthiscausedmassivethymocyteapoptosisatphysiologicalhormonelevels,whichcouldbereversedbyadrenalectomy.Duetohomeost...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第3期Morethancolocalizingwithpolycystin-1,polycystin-Lisinthecentrosome
【摘要】Polycystin-1andpolycystin-2areinvolvedinautosomaldominantpolycystickidneydiseasebyunknownmechanisms.Thesetwoproteinsarelocatedinprimaryciliawheretheymediatemechanosensation,suggestingalinkbetweenciliafunctionandrenaldisease.Inthisstudy,wesoughttocharacterizethesubcellularlocalizationofpo...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期Blood-brainbarriertraversalbyAfricantrypanosomesrequirescalciumsignalinginducedbyparasitecysteineprotease
1DepartmentofPediatrics,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,Maryland,USA.2InstitutodeBiofísicaCarlosChagasFilho,UniversidadeFederaldoRiodeJaneiro,RiodeJaneiro,Brazil.3CenterforBiophysicalSciencesandEngineering,UniversityofAlabama,Birmingham,Alabama,USA.4DepartmentofParasitology,KurumeU...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期pCipProtectionagainstHyperoxiaRequiresBcl-XLandIsUncoupledfromItsAbilitytoSuppressGrowth
...torp21Cip1/Waf1/Sdi1protectsthelungagainsthyperoxia,butthemechanismofprotectionremainsunclearbecauselossofp21doesnotleadtoaberrantcellproliferation.BecausesomemembersoftheBcl-2genefamilyhavebeenimplicatedinhyperoxia-inducedcelldeath,thecurrentstudyinvestigatedtheirexpressionaswellasp21-dependentgrow...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期AlbuminoverloadinducesadaptiveresponsesinhumanproximaltubularcellsthroughoxidativestressbutnotviaangiotensinIItype1receptor
...ectsofhumanserumalbumin(HSA)overloadonthechangesingeneandproteinexpressionstimulatedbyoxidativestressinPTCandanyinteractionwithANGIIthatispivotalindiseasepathogenesis.Markersofoxidativestress,antioxidantdefences,transcriptionfactoractivation,andtheexpressionofstress-relatedgenesweremeasuredinhumanPT...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第6期