InadequacyoftheJanusKinase2/SignalTransducerandActivatorofTranscriptionSignalTransductionPathwaytoMediateEpisodicGrowthHormone-DependentReg
LaboratoriesofBiochemistry,SchoolofVeterinaryMedicine,UniversityofPennsylvania,Philadelphia,PennsylvaniaAbstractCYP2C11,themostcommonlyexpressedhepaticcytochromeP450isoforminmalerats,isinducedbythemasculine“episodic“secretorygrowthhormoneprofile.Aconsiderablenumberofreportshaveindicatedthatepiso...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期-DominantGranulomatousPathologyDoesNotInhibitFibrosisorCauseLethalityduringMurineSchistosomiasis
...ndentmechanism.Inthisstudy,weaskedwhetherCD4+T-cell-specificIL-4R-deficientmice(LckCreIL-4RC/lox)developedgranulomasandegg-drivencollagenproduction.AlthougheosinophiliaandgobletcellhyperplasiawereimpairedinLckCreIL-4RC/loxmice,therewasnoreductioninsizeorcollagencontentoflungandlivergranulomas.Thelac...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期ChemokineReceptor
...ocytesandCXCL10/IP-10bykeratinocytesandendothelialcellsduringwoundhealinginmiceandhumans.Invitro,theseligandslimitmotilityindermalfibroblastsandendothelialcells.Toexaminewhetherthissignalingpathwaycontributestowoundhealinginvivo,full-thicknessexcisionalwoundswerecreatedonCXCR3wild-type(+/+)orknockou...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期ACommonRegulatoryRegionFunctionsBidirectionallyinTranscriptionalActivationoftheHumanCYP1A1andCYP1A2Genes
...manycytochromesP450involvedintheoxidativemetabolismofdrugs,environmentalchemicals,andendogenouscompounds(DenisonandWhitlock,1995).Treatmentofexperimentalanimalsandhumanswithchemicalssuchas2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD),-naphthoflavone(BNF),or3-methylchorantherene(3-MC)isknowntoenhanceexpr...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期ArseniteInhibitionofCYP1A1Inductionby2,3,7,8-Tetrachlorodibenzo-p-dioxinIsIndependentofCellCycleArrest
LaboratoryofEnvironmentalToxicology,DepartmentsofPharmacology,ChemistryBiochemistry,UniversityofCalifornia,SanDiego,LaJolla,CaliforniaAbstractWeshowherethatarsenite(As3+)elicitsmultipleeffectsongenecontrol,suchastheinterruptionofcellcyclecontrolbyinitiatingG2/Marrestaswellasinhibitingthearylhydrocar...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第4期Permissiveroleofnitricoxideinmaculadensacontrolofreninsecretion
...performedinneuronal(nNOS)-andendothelialnitricoxidesynthase(eNOS)-deficientmicetostudytheroleofnitricoxide(NO)inmaculadensacontrolofreninsecretioninvivoandintheisolated,perfusedmousekidney.Acuteandchronicadministrationofloopdiureticswasusedasamethodtostimulatemaculadensa-mediatedreninsecretion.Incre...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第5期MAPkinasephosphatase1controlsinnateimmuneresponsesandsuppressesendotoxicshock
...ScienceGraduateProgram,TheOhioStateUniversity,Columbus,OH432053DepartmentofMicrobiologyandImmunology,IndianaUniversity,Indianapolis,IN47405Septicshockisaleadingcauseofmorbidityandmortality.However,geneticfactorspredisposingtosepticshockarenotfullyunderstood.Excessiveproductionofproinflammatorycytoki...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期Aregion-basedmathematicalmodeloftheurineconcentratingmechanismintheratoutermedulla.II.Parametersensitivityandtubularinhomogeneity
...rs.InstudyI,wemadeassumptionsthatappearedreasonabletous;inthisstudyII,weexaminehowvariationintheseuncertainparametersaffectsmodelresults.Ofparticularimportanceisapredictionthatregionalizationhasasignificantimpactonsoluteconcentrations,andthereforeosmolality,ofcollectingduct(CD)tubularfluidthatenters...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第12期Down-RegulationofDNATopoisomeraseIILeadstoProlongedCellCycleTransitinG2andEarlyMPhasesandIncreasedSurvivaltoMicrotubule-InteractingAgent
...ecularandCellularPharmacology,DepartmentofPharmaceuticalTechnologyandBiochemistry,GdanskUniversityofTechnology,Gdansk,Poland(A.S.,M.S.)AbstractMicrotubulebindersarecellcycle-specificagentswithpreferentialcytotoxicitytowardmitoticcells.Wehavecharacterizedvincristine-selectedhumanleukemiacellstoestabl...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期Prostasinattenuatesinduciblenitricoxidesynthaseexpressioninlipopolysaccharide-inducedurinarybladderinflammation
...hainreactioninthebladder,andtheprostasinproteinwaslocalizedbyimmunohistochemistryintheurothelialcells.Inmiceinjectedintraperitoneallywithbacteriallipopolysaccharide(LPS),bladderprostasinmRNAexpressionwasdownregulated,whereastheexpressionofinduciblenitricoxidesynthase(iNOS),cyclooxygenase-2(COX-2),in...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第9期