AntitumorigenicEffectsofPeroxisomeProliferator-ActivatedReceptor-inNon-Small-CellLungCancerCellsAreMediatedbySuppressionofCyclooxygenase-2via
【关键词】Factor-BPharmacologicalactivatorsofperoxisomeproliferator-activatedreceptor-(PPAR)inhibitgrowthofnon-small-celllungcancer(NSCLC)celllinesinvitroandinxenograftmodels.Becausetheseagentsengageoff-targetpathways,wehaveassessedtheeffectsofPPARbyoverexpressingtheproteininNSCLCcells.Wereport...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期Cell-derivedanaphylatoxinsaskeymediatorsofantibody-dependenttypeIIautoimmunityinmice
...lHannover,Hannover,Germany.2DepartmentofImmunology,GeorgAugustUniversityG?ttingen,G?ttingen,Germany.3DepartmentofHumanGenetics,LeidenUniversityMedicalCentre,Leiden,TheNetherlands.AbstractComplementC5a,apotentanaphylatoxin,isacandidatetargetmoleculeforthetreatmentofinflammatorydiseases,suchasmyocardi...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期RegulationofCytochromeP4502E1underHypertonicEnvironmentthroughTonEBPinHumanHepatocytes
【关键词】RegulationWhereastheliveraswellastheotherorgansarecontinuallyexposedtothechangeofosmoticstatus,ithasneverbeeninvestigatedwhetheractivitiesandgeneexpressionsofdrug-metabolizingenzymes,includingcytochromesP450,aredependentonosmoticchangeintheliver.Inthepresentstudy,wedeterminedthatCYP2E...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期MolecularmechanismsofenhancedrenalcelldivisioninprotectionagainstS-1,2-dichlorovinyl-L-cysteine-inducedacuterenalfailureanddeath
...nces,TheUniversityofLouisianaatMonroe,Monroe,LouisianaDepartmentofPharmaceuticalSciences,MedicalUniversityofSouthCarolina,Charleston,SouthCarolinaABSTRACTSustainedactivationofERK1/2byalowdose(15mg/kgip)ofS-1,2-dichlorovinyl-L-cysteine(DCVC)72hbeforeadministrationofalethaldoseofDCVC(75mg/kgip)enhance...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第7期FactorVIIIectopicallytargetedtoplateletsistherapeuticinhemophiliaAwithhigh-titerinhibitoryantibodies
1BloodResearchInstitute,BloodCenterofWisconsin,Milwaukee,Wisconsin,USA.2DepartmentsofPediatrics,Physiology,Microbiology,andOrthopedics,MedicalCollegeofWisconsin,Milwaukee,Wisconsin,USA.3Children’sResearchInstitute,Children’sHospitalofWisconsin,Milwaukee,Wisconsin,USA.AbstractInhibitoryimmuneresp...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期CDTCellsModulateCDT-CellandEosinophil-MediatedPulmonaryPathologyinPneumocystisPneumoniainB-Cell-DeficientMice
【摘要】Pneumocystisspp.pneumonia(PCP)inhumansandinsurrogateanimalspeciestypicallyoccursintheabsenceofCD4Tcells,astakesplaceduringacquiredimmunedeficiencysyndrome.However,patientstreatedwithhighlyactiveanti-retroviraltherapysometimesexhibitanexacerbationofdiseasessuchasPCPthatcoincideswithresurg...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第2期ReciprocalRegulationofAgonistandInverseAgonistSignalingEfficacyuponShort-TermTreatmentoftheHuman-OpioidReceptorwithanInverseAgonist
....D.),FaculteedeMeedecine,UniversiteedeMontreeal,Montreeal,Queebec,CanadaInstitutdeRecherchesCliniquesdeMontreeal(P.W.S.),UniversiteedeMontreeal,Montreeal,Queebec,CanadaAbstractRapidregulationofreceptorsignalingbyagonistligandsiswidelyaccepted,whereasshort-termadaptationtoinverseagonistshasbeenlittle...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第1期EnhancedExpressionofKeratinocyteGrowthFactorandItsReceptorCorrelateswithVenousInvasioninPancreaticCancer
【摘要】Keratinocytegrowthfactor(KGF)andKGFreceptor(KGFR)havebeenimplicatedincancergrowthaswellastissuedevelopmentandrepair.Inthisstudy,weexaminedwhetherKGFandKGFRhavearoleinhumanpancreaticductaladenocarcinoma(PDAC).KGFRmRNAwasexpressedineightpancreaticcancercelllines,whereastheKGFmRNAwasdetecte...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期RepressionofT-CellFunctionbyThionamidesIsMediatedbyInhibitionoftheActivatorProtein-1/NuclearFactorofActivatedT-CellsPathwayandIsAssociate
...e-inducedimmunosuppressionisunclear.Hereweshowthatthionamidesdirectlyinhibitinterleukin-2cytokineexpression,proliferation,andtheactivation(CD69expression)ofprimaryhumanTlymphocytes.InhibitionofimmunefunctionwasassociatedwitharepressionofDNAbindingofthecooperativelyactingimmunoregulatorytranscription...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期AmeliorationofCoxsackievirusB-MediatedMyocarditisbyInhibitionofTissueInhibitorsofMatrixMetalloproteinase-
【摘要】CoxsackievirusB3(CVB3)isamajorcauseofacutemyocarditis,aseriousconditionthatisrefractorytotreatment.Myocardialdamageresultsintissueremodelingthat,iftooextensive,maycontributetodisease.Remodelingisachievedbyextracellularproteolysismediatedbythematrixmetalloproteinases(MMPs),andMMPactivityi...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期