StichodactylahelianthusPeptide,aPharmacologicalToolforStudyingKv3.2Channels
...characterized,thestudyofothers,suchasKv3channels,hasbeenhinderedbecauseoflimitedpharmacologicaltools.ThecurrentstudywasinitiatedtoidentifypotentblockersoftheKv3.2channel.Chinesehamsterovary(CHO)-K1cellsstablyexpressinghumanKv3.2b(CHO-K1.hKv3.2b)wereestablishedandcharacterized.Stichodactylahelianthus...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期ObligatoryRoleforInterleukin-inObstructiveLesionDevelopmentinAirwayAllografts
...mmatoryandprofibroticactions,acontributoryroleforIL-13inBOdevelopmentwasexaminedusingmurinemodelsoforthotopicandheterotopictrachealtransplantation.Comparedwithairwayisografts,allograftsexhibitedasignificantincreaseinrelativeIL-13mRNAandproteinlevels.AllogeneictracheastransplantedintoIL-13-deficientm...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期CharacterizationoftheTritium-LabeledAnalogofL-threo--BenzyloxyaspartateBindingtoGlutamateTransporters
【关键词】CharacterizationL-Glutamateisthemajorexcitatoryneurotransmitterinthemammaliancentralnervoussystem.Terminationofglutamatereceptoractivationandmaintenanceoflowextracellularglutamateconcentrationsareprimarilyachievedbyglutamatetransporters(excitatoryaminoacidtransporters1-5,EAATs1-5)loca...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期Cocoapolyphenolsandinflammatorymediators
HelmutSies,TankredSchewe,ChristianHeissandMalteKelm1FromInstituteforBiochemistryandMolecularBiologyI(HS,TS,CH)andtheDepartmentofMedicine,DivisionofCardiology,PulmonaryDiseases,andAngiology(CH,MK),HeinrichHeineUniversityDüsseldorf,Düsseldorf,Germany2Presentedatthe1stInternationalConferenceo...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第1期AnEssentialRoleforConstitutiveEndocytosis,butNotActivity,intheAxonalTargetingoftheCB1CannabinoidReceptor
...torsubtype-1(CB1)ishighlypolarizedtowardaxonsandisassociatedwithsynapticterminals,inwhichitiswell-positionedtomodulateneurotransmitterrelease.IthasbeensuggestedthathighlevelsofconstitutiveactivitymediateCB1receptoraxonaltargeting,leadingtodomain-specificendocytosis.Wehaveinvestigatedfurtherthemechan...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期IntrapulmonaryDeliveryofRicinatHighDosageTriggersaSystemicInflammatoryResponseandGlomerularDamage
...ofthepossibilitythatricinmaybeusedasabioweaponagainsthumanpopulations,weexaminedthepathologicalconsequencesthatoccurinmiceafterintroductionofricinintothepulmonarysystem.Intratrachealinstillationofalethaldoseofricin(20µg/100gbodyweight)resultedinahemorrhagicinflammatoryresponseinmultipleorgans,...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期-Tocopheroldisappearanceisfasterincigarettesmokersandisinverselyrelatedtotheirascorbicacidstatus
...rtedbygrantstoMGT(NIHDK59576)andTJM(AG05144andAG16835).TheNaturalSourceVitaminEAssociationprovidedpartialsupportforthepurchaseoftheLC-MSandprovidedthedeuterium-labeled-tocopherylacetatesupplements.Tocopherolstandardsincludingd0-(unlabeled),d6-RRR,andd3-all-rac--tocopherylacetatesandunlabeledd0--toco...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第1期Metabolicacidosishasdualeffectsonsodiumhandlingbyratkidney
...channelSgkTHEKIDNEYPLAYSANIMPORTANTroleintheregulationandmaintenanceofsystemicacid-basebalance.Inresponsetoanacidinsult,thekidneyundergoesseveraladaptivechangesinitsfunctionandappropriatelyincreasesacidexcretionintheurine(13).Thisleadstothecorrectionofmetabolicacidosisandthuspreventsthedevelopmentof...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期Vascularendotheliumiscriticallyinvolvedinthehypotensiveandhypovolemicactionsofatrialnatriureticpeptide
...ination.Notably,despitefullpreservationofthedirectvasodilatingeffectsofANP,micewithendothelium-restricteddeletionoftheGC-Agene(ECGC-AKO)exhibitedsignificantarterialhypertensionandcardiachypertrophy.EchocardiographicandDopplerflowevaluationstogetherwiththeEvan’sbluedilutiontechniqueshowedthatthetot...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期Arachidonicacid–anddocosahexaenoicacid–enrichedformulasmodulateantigen-specificTcellresponsestoinfluenzavirusinneonatalpiglets
JosepBassaganya-Riera1,AmirJGuri1,AlexisMNoble1,KathrynAReynolds1,JenniferKing1,CynthiaMWood1,MichaelAshby1,DeshanieRai1andRaquelHontecillas11FromtheNutritionalImmunologyMolecularNutritionLaboratory,DepartmentofHumanNutritionFoodsandExercise(JB-R,AJG,AMN,KAR,JK,andRH),andtheDepartmentofAnimalandPoul...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第3期