AssessingtheassociationbetweenvitaminB-12statusandcognitivefunctioninolderadults
...406.Itiswellestablishedthattheclinicalmanifestationsofovert,severevitaminB-12deficiencyincludebothhematologic(macrocyticormegaloblasticanemia)andneurologic(subacutecombineddegenerationofthespinalcord,peripheralneuropathy,cognitiveimpairment)sequelae.Theneurologicconsequencesareofparticularconcern,be...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第6期白细胞介素12及其抗肿瘤作用
IL-12是新近发现的一种细胞因子,具有多种生物学活性,尤其是在抗肿瘤免疫和抗病毒免疫中有重要的作用。 一、IL-12概况 IL-12主要来源于单核/巨噬细胞、抗原递呈细胞和B细胞,是由相对分子质量为40×103和35×103两个亚...
合作平台;医学论文;外科论文;普通外科学EffectoforalvitaminB-12withorwithoutfolicacidoncognitivefunctioninolderpeoplewithmildvitaminB-12deficiency:arandomized,placebo-controll
...tQLK3-CT-2002-01775fromtheFoundationtoPromoteResearchIntoFunctionalVitaminB12DeficiencyandtheEuropeanUnionBIOMEDDemonstrationProject;andgrant2004-E2fromtheNutriciaHealthFoundation,Wageningen,Netherlands.3AddressreprintrequeststoLCdeGroot,DivisionofHumanNutrition,WageningenUniversity,POBox8129,6700EV...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第2期TransgenicOverexpressionofADAMSuppressesMuscleRegenerationandAggravatesDystrophyinAgedmdxMice
...rationandgradualreplacementoftheskeletalmusclebyfatandconnectivetissue.ADAM12haspreviouslybeenshowntoalleviatethepathologyofyoungdystrophin-deficientmdxmice,amodelforDuchennemusculardystrophy.TheobservedeffectofADAM12wassuggestedtobemediatedviaamembrane-stabilizingup-regulationofutrophin,7Bintegrin,...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期MMP-12与动脉粥样硬化
...Collagenases(MMP-1,-8,-13)Gelatinases(MMP-2,-9)Stromelysins(MMP-3,-10,-11,-12)Membrane-typeMMPs(MMP-14~17and-24~25)Others:matrilysin(MMP-7,-19-24,-26)TheFunctionsofMMPsPhysiological:EmbryonicdevelopmentOrganmorphogenesisNervegrowthBoneremodelingWoundhealingOvulationAngiogenesisPathological:Emphysema...
医源资料库;医学文档库;心血管相关2009国家自然科学基金项目(生物类)
...学170人类NADPHsensor蛋白HSCARG调控机制研究郑晓峰30930020/C05012010-01至2013-12北京大学180结构修饰的siRNA合成和RNA干扰技术在药物靶标寻找中的研究张礼和20932001/B0207022010-01至2013-12北京大学180p53和PTEN之间的分子联系研究尹玉新30930021/C05...
医学教育;科教新闻RemovalofFkbp12/12.6FromEndothelialRyanodineReceptorsLeadstoanIntracellularCalciumLeakandEndothelialDysfunction
【摘要】Objectives-FK506BindingProtein12anditsrelatedisoform12.6(FKBP12/12.6)stabilizeaclosedstateofintracellularCa2+releasechannels(ryanodinereceptors),andinmyocytesremovalofFKBP12/12.6fromRyRsaltersintracellularCa2+levels.TheimmunosuppressivedrugsrapamycinandFK506bindanddisplaceFKBP12/12.6from...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期Transcobalamin776CGpolymorphismnegativelyaffectsvitaminB-12metabolism
...C)776CG]mayaffectthefunctionoftranscobalamin,theproteinrequiredforvitaminB-12cellularuptakeandmetabolism.Remethylationofhomocysteineisdependentontheproductionof5-methyltetrahydrofolateandadequatevitaminB-12forthemethioninesynthasereaction.Objectives:TheobjectivesweretoassesstheinfluenceoftheTC776CGp...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第6期5.11维生素B12
5.11维生素B12 5.11.1结构与性质 维生素B12(VB12)为钴胺素(Cobalamin)类化合物,他的分子中有4个还原性吡咯环联结在一起,这种构叫做咕啉,他与核苷酸(二甲基苯异咪唑)及核糖相联,另一方面与D-1-氨基-2-丙醇相...
医源资料库;医源图书馆;教材类;临床营养学Holo-transcobalaminisanindicatorofvitaminB-12absorptioninhealthyadultswithadequatevitaminB-12status
...eenhypothesizedthattheresponseofholo-transcobalamin(holo-TC)tooralvitaminB-12maybeusedtoassessabsorption.Todevelopareliableclinicalabsorptiontestthatusesholo-TC,itisnecessarytodeterminetheoptimaltimelineforvitaminB-12administrationandpostdoseassessment.Objective:Theobjectiveofthisstudywastoassessthe...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第4期