ReducedExpressionofDNATopoisomeraseIinSF295HumanGlioblastomaCellsSelectedforResistancetoHomocamptothecinandDiflomotecan
...hecurrentlyusedcamptothecin(CPT)analogsirinotecanandtopotecan.ThehCPTderivativediflomotecan(BN80915)iscurrentlyinclinicaltrials.Weestablishedtworesistanthumanglioblastomacelllines,SF295/hCPT50andSF295/BN50,bystepwiseexposureoftheparentalSF295linetoincreasingconcentrationsofhCPTandBN80915,respectivel...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期SynergisticroleofmicronemalproteinsinToxoplasmagondiivirulence
...UMRUniversité-INRAd‘ImmunologieParasitaires,FacultédesSciencesPharmaceutiquesetBiologiques,37200Tours,France2UMR5539CNRS,UniversitédeMontpellier2,34090Montpellier,France3FRE2377CNRS,InstitutdeBiologiedeLille,59021Lille,FranceApicomplexanparasitesinvadecellsbyauniquemechanisminvolvingdischargeof...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期ChemicalInducersofRodentGlutathioneS-TransferasesDown-RegulateHumanGSTA1TranscriptionthroughaMechanismInvolvingVariantHepaticNuclearFactor1-
【关键词】ChemicalInducersTheregulationofhumanGSTA1bychemicalinducersofrodentglutathioneS-transferases(GSTs)andtheregulatoryroleofhepaticnuclearfactor(HNF)1wasinvestigatedinCaco-2cells.Treatmentofpreconfluentandconfluentcellswith12-O-tetra-decanoylphorbol-13-acetate(TPA),3-methylcholanthrene(3-...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期Blockingthe4integrinpaxillininteractionselectivelyimpairsmononuclearleukocyterecruitmenttoaninflammatorysite
...rseveralautoimmuneandinflammatorydiseasesbutmayexhibitmechanism-basedtoxicities.Wetestedthecapacityofblockadeof4integrinsignalingtoperturbfunctionsinvolvedininflammation,whilelimitingpotentialadverseeffects.WegeneratedandcharacterizedmicebearingaY991Amutationin4integrin,whichblockspaxillinbindingand...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期Intrarenalcells,notbonemarrow–derivedcells,arethemajorsourceforregenerationinpostischemickidney
...UniversityofTexasSouthwesternMedicalCenteratDallas,Dallas,Texas,USA.AbstractIschemicinjurytothekidneyproducesacutetubularnecrosisandapoptosisfollowedbytubularregenerationandrecoveryofrenalfunction.Althoughmitoticcellsarepresentinthetubulesofpostischemickidneys,theoriginsoftheproliferatingcellsarenot...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期VaginalSubmucosalDendriticCellsbutNotLangerhansCellsInduceProtectiveTh1ResponsestoHerpesSimplexVirus-2
...ySchoolofMedicine,NewHaven,CT065202DepartmentofMicrobiologyandMolecularGenetics,HarvardMedicalSchool,Boston,MA02115 AbstractTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesHerpessimplexvirus(HSV)type2infectionoccursprimarilyatthegenitalmucosalsurfacesandisaleadingcauseofulcera...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第2期GeneticMappinginMiceIdentifiesDMBTasaCandidateModifierofMammaryTumorsandBreastCancerRisk
【摘要】Low-penetrancebreastcancersusceptibilityallelesseemtoplayasignificantroleinbreastcancerriskbutaredifficulttoidentifyinhumancohorts.Ageneticscreenof176N2backcrossprogenyoftwoTrp53+/Cstrains,BALB/candC57BL/6,whichdifferintheirsusceptibilitytomammarytumors,identifiedamodifierofmammarytumors...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期OrphannuclearreceptorTR3/Nur77regulatesVEGF-A–inducedangiogenesisthroughitstranscriptionalactivity
...MedicalSchool,Boston,MA02215Vascularendothelialgrowthfactor(VEGF)-Ahasessentialrolesinvasculogenesisandangiogenesis,butthedownstreamstepsandmechanismsbywhichhumanVEGF-Aactsareincompletelyunderstood.WereportherethathumanVEGF-Aexertsmuchofitsangiogenicactivitybyup-regulatingtheexpressionofTR3(mousehom...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期Tamm-HorsfallglycoproteinlinksinnateimmunecellactivationwithadaptiveimmunityviaaToll-likereceptor-4–dependentmechanism
...ogyandMetabolism,MedicalUniversityVienna,Vienna,Austria.4LudwigBoltzmannInstituteforRheumatology,Vienna,Austria.5InstituteofImmunology,MedicalUniversityVienna,Vienna,Austria.6CenterofMolecularMedicine(CeMM),AustrianAcademyofSciences,ClinicalDivisionofEndocrinologyandMetabolism,MedicalUniversityVienn...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期-wProtectsHippocampusduringExperimentalStatusEpilepticus
【摘要】Experimentallyevokedseizurescanactivatetheintrinsicmitochondrialcelldeathpathway,componentsofwhicharemodulatedinthehippocampusofpatientswithtemporallobeepilepsy.Bcl-2familyproteinsarecriticalregulatorsofmitochondrialdysfunction,buttheirsignificanceinthissettingremainsprimarilyuntested.Pr...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期