MastCellsPlayaCrucialRoleinStaphylococcusaureusPeptidoglycan-InducedDiarrhea
...ldeachyear.Themechanismneedstobefurtherunderstood.Staphylococcusaureusinfectionhasacloserelationwithdiarrhea;itscellwallcomponentpeptidoglycan(PGN)hasstrongbiologicalactivityonimmunecellsandpossiblyplaysaroleinS.aureus-induceddiarrhea.ThepresentstudyshowedthatoralPGN-induceddiarrheainmiceinadose-dep...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期StructuralDeterminantsforHigh-AffinityZolpidemBindingtoGABA-Areceptors
...assicbenzodiazepines(BZDs),zolpidembindsattheextracellularN-terminal/subunitinterfaceoftheGABA-Areceptor(GABAR).However,zolpidemdifferssignificantlyfromclassicBZDsinchemicalstructureandneuropharmacologicalproperties.Thus,classicBZDsandzolpidemarelikelytohavedifferentrequirementsforhigh-affinitybindi...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期Thrombomodulin-ProteinC-EPCRSystem
...TechnologyandGeneTherapy,UniversityofLeuvenandtheFlandersInteruniversityInstituteforBiotechnology(VIB),Belgium.ABSTRACTLateinthe18thcentury,WilliamHewsonrecognizedthattheformationofaclotischaracteristicofmanyfebrile,inflammatorydiseases(OwenC.AHistoryofBloodCoagulation.Rochester,Minnesota:MayoFounda...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第8期ThePlateletAggregation-InducingFactorAggrus/PodoplaninPromotesPulmonaryMetastasis
【摘要】Tumorcell-inducedplateletaggregationhasbeenreportedtofacilitatehematogenousmetastasis.Aggrus/podoplaninisaplateletaggregation-inducingfactorthatisup-regulatedinanumberofhumancancersandhasbeenimplicatedintumorprogression.WestudiedhereintheroleofAggrusintumorgrowth,metastasis,andsurvivalin...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期GlucocorticoidimpairsgrowthofkidneyoutermedullaandacceleratesloopofHenledifferentiationandurinaryconcentratingcapacityinratkidneydevelopme
【摘要】Intherat,urinaryconcentratingabilitydevelopsprogressivelyduringthethirdpostnatal(P)weekandnearlyreachesadultlevelatweaning(P21)governedbyariseincirculatingglucocorticoid.Elevatedextracellularosmolalitycanleadtogrowtharrestofepithelialcells.Wetestedthehypothesisthatsupranormalexposureofra...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第10期Diabetes-InducedMechanicalHyperalgesiaInvolvesSpinalMitogen-ActivatedProteinKinaseActivationinNeuronsandMicrogliaviaN-Methyl-D-aspartate-Depende
...ptozotocin-induceddiabetes,thatmechanicalhyperalgesia,acommonsymptomofdiabeticneuropathy,wascorrelatedwithanearlyincreaseinextracellularsignal-regulatedproteinkinase(ERK),p38,andc-JunN-terminalkinase(JNK)phosphorylationinthespinalcordanddorsalrootganglionat3weeksafterinductionofdiabetes.Thischangewa...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期TheInductionofGrowthArrestDNADamage-InducibleGeneßinHumanHepatomaCellLinesbyS-Adenosylmethionine
【摘要】Down-regulationofGADD45ß,whichisknowntoinfluencecellgrowthcontrol,apoptosis,andcellularresponsetoDNAdamage,hasbeenverifiedtobespecificinhepatocellularcarcinomaandconsistentwiththedegreeofmalignancy.Here,weidentifiedpromoterelementsforseveraltranscriptionalfactorsintheproximalpromot...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期IntensifiedandprotectiveCD4+Tcellimmunityinmicewithanti–dendriticcellHIVgagfusionantibodyvaccine
...ciencyvirus(HIV)vaccineapproachesemphasizeprimebooststrategiescomprisingmultipledosesofDNAvaccineandrecombinantviralvectors.Wearedevelopingaprotein-basedapproachthatdirectlyharnessesprinciplesforgeneratingTcellimmunity.Vaccineisdeliveredtomaturingdendriticcellsinlymphoidtissuebyengineeringproteinant...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期关于第二批化学药品统一说明书工作任务的下发通知
...TC]双半胱氨酸注射液3.锝[Tc]甲氧异腈注射液4.氯化亚铊[201TI]注射液5.尿素[14C]呼气试验药盒6.碳[14C]尿素呼气试验药盒7.亚锡硫乙甘肽冻干品8.亚锡双半胱氨酸冻干品9.注射用亚锡甲氧异腈10.注射用亚锡葡庚糖酸钠11.注射用亚锡双半...
医源资料库;医药卫生法规大全;药政类(药品、食品、器械);药品法规RARiscriticalformaintainingabalancebetweenhematopoieticstemcellself-renewalanddifferentiation
...aHumanBiologyDivision,FredHutchinsonCancerResearchCenter,Seattle,WA98109InstitutdeGénétiqueetdeBiologieMoléculaireetCellulaire,CentreNationaldelaRechercheScientifique/InstitutNationaldelaSantéetdelaRechercheMédicale/ULP/CollègedeFrance,67404IllkirchCedex,CUdeStrasbourg,FranceHematopoieticstemc...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第5期