TransformingGrowthFactor-ßSuppressesCollagenCleavageinCulturedHumanOsteoarthriticCartilageReducesExpressionofGenesAssociatedwithChondro
...ibitablebygrowthfactorsknowntosuppressgrowthplatehypertrophy,namelytransforminggrowthfactor(TGF)-ß2,fibroblastgrowthfactor(FGF)-2,andinsulin.Full-depthexplantsofhumanOAkneearticularcartilagefromarthroplastywereculturedwithTGF-ß2,FGF-2,andinsulinincombination(growthfactors)orindividually....
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期NovelRolesofLocalInsulin-LikeGrowthFactor-ActivationinGastricUlcerHealing
...r(IGF)-1ingastriculcerhealingisunknown.Inexperimentalratgastriculcers,weexaminedexpressionofIGF-1mRNAandproteinbyreversetranscriptase-polymerasechainreactionorenzyme-linkedimmunosorbentassayandimmunostaining,respectively.InculturedratgastricepithelialRGM1cells,weexaminedeffectsofexogenousIGF-1oncell...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期SerumAmyloidAInducesContraryImmuneResponsesviaFormylPeptideReceptor-Like1inHumanMonocytes
...ionallevels.SignalingeventsinducedbyserumamyloidAincludedtheactivationoftwomitogen-activatedproteinkinases(extracellularsignal-regulatedkinaseandp38kinase),whichwerefoundtoberequiredforTNF-andIL-10production,respectively.Thestimulationofformylpeptidereceptor-like-1-expressingRBL-2H3cells,butnotofvec...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期RestorationofliverinsulinsignalinginInsrknockoutmicefailstonormalizehepaticinsulinaction
...ressioninbrain,liver,andpancreatic?cellsissufficientforrescuingInsrknockoutmicefromneonataldeath,preventingdiabetesketoacidosis,andnormalizinglifespanandreproductivefunction.However,thetransgenicallyrescuedmice(referredtoasL1)havemarkedhyperinsulinemia,andapproximately30%developlate-onsettype2diabet...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第5期MaternalCocaineAdministrationCausesanEpigeneticModificationofProteinKinaseCGeneExpressioninFetalRatHeart
...nalProteinkinaseC(PKC)playsapivotalroleincardioprotectionduringcardiacischemiaandreperfusioninjury.RecentstudiesdemonstratedthatprenatalcocaineexposurecausedadecreaseinPKCexpressionandincreasedheartsusceptibilitytoischemicinjuryinadultoffspring,suggestinganinuteroprogrammingofPKCgeneexpressionpatter...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第5期Interferon-InducesChronicActiveMyocarditisandCardiomyopathyinTransgenicMice
...own.ToinvestigatethisissueweanalyzedthecardiacphenotypeofSAP-IFN-transgenicmice,whichconstitutivelyexpressIFN-intheirliversandhenceexhibithighcirculatingserumlevelsofthiscytokine.SAP-IFN-micespontaneouslydevelopedchronicactivemyocarditis,characterizedbytheinfiltrationofnotonlyCD4+andCD8+Tcellsbutals...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期H2O2-inducedtransactivationofEGFreceptorrequiresSrcandmediatesERK1/2,butnotAkt,activationinrenalcells
...O2)stimulatedSrc,EGFR,ERK1/2,andAktactivationinatime-dependentmannerasdeterminedbythephosphorylationofeachprotein.TheSrcinhibitorPP1completelyblockedEGFR,ERK1/2,andAktphosphorylationfollowingH2O2exposure.Incontrast,blockadeoftheEGFRbyAG1478inhibitedphosphorylationofERK1/2butnotSrcorAktphosphorylatio...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第5期ThromboxaneA2PromotesInterleukin-6BiosynthesisMediatedbyanActivationofCyclicAMP-ResponseElement-BindingProteinin1321N1HumanAstrocytomaCells
...bySB203580[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole],ap38mitogen-activatedproteinkinase(MAPK)inhibitor,andH89[N-[2-(4-bromocinnamylamino)-ethyl]-5-isoquinoline],aproteinkinaseA(PKA)inhibitor,indicatinginvolvementsofp38MAPKandPKAinCREBactivationandIL-6expression.Todete...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期SalmonellaEffectorAvrARegulationofColonicEpithelialCellInflammationbyDeubiquitination
...UnitedStates.MostpersonsinfectedwithSalmonelladevelopdiarrhea,fever,andabdominalcramps12to72hoursafterinfection.AvrAisaSalmonellaeffectortranslocatedintohostcellsbyatype3secretionsystem.RecentlystudiesshowedthattheAvrAgeneispresentin80%ofSalmonellaentericaserovar.1Althoughitsexactfunctionisnotentire...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期Physiologicalsignificanceofhypotonicity-inducedregulatoryvolumedecrease:reductioninintracellularCl-concentrationactingasanintracellularsignal
...gH2O),arapidincreaseofcellvolumefollowedbyRVDoccurred.TheRVDcauseddrasticdiminutionof[Cl-]ifrom43.6to10.8mM.UnderanRVD-blockedconditionwithNPPB(Cl-channelblocker)orquinine(K+channelblocker),wedidnotdetectthereductionof[Cl-]i.Basedontheseobservations,weconcludethatoneofthephysiologicalsignificancesof...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期