Serotonergicdrugsandspinalcordtransectionsindicatethatdifferentspinalcircuitsareinvolvedinexternalurethralsphincteractivityinrats
...effectsof5-HT1Areceptoragonist(8-OH-DPAT)andantagonist(WAY100635)drugstoexaminetheoriginoftonicandburstingEUSactivity.EUSactivitywaselicitedbybladderdistensionorelectricalstimulationofafferentaxonsinthepelvicnerve(pelvic-EUSreflex).Tonicactivityevokedbybladderdistensionwasdetectedinspinalcord-intact...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第3期Temporalexpressionprofileanddistributionpatternindicatearoleofconnectivetissuegrowthfactor(CTGF/CCN-2)indiabeticnephropathyinmice
...forebeenimplicatedinitspathogenesis.TheobjectiveofthepresentstudywastodeterminethetissuedistributionofincreasedCTGFexpressionandtherelationshipofplasma,urinary,andrenalCTGFlevelstothedevelopmentandseverityofDN.WestudiedtherelationshipbetweenCTGFandrenalpathologyinstreptozotocin(STZ)-induceddiabetesi...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第6期Poly(ADP-ribose)polymerase-1geneablationprotectsmicefromischemicrenalinjury
...y(ADP-ribose)polymerase-1(PARP-1)havebeenimplicatedinthepathogenesisofischemicinjury.WepreviouslydemonstratedthatpharmacologicalinhibitionofPARPprotectsagainstischemicrenalinjury(IRI)inrats(MartinDR,LewingtonAJ,HammermanMR,andPadanilamBJ.AmJPhysiolRegulIntegrCompPhysiol279:R1834R1840,2000).Tofurther...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第2期PharmacologicalCharacterizationofaNovelNonpeptideAntagonistforFormylPeptideReceptor-Like1
...-butoxy-N-[2-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-2H-quinazolin-3-yl]-benzamide(Quin-C1;C1),whereasahydroxylsubstitutionresultedinapureantagonist,Quin-C7(C7).Severalpartialagonistswerederivedfromothersubstitutionsontheparaposition.C7partiallydisplaced[125I]Trp-Lys-Tyr-Met-Val-D-Met-NH2(WKYMVm)bindin...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期TheInvestigationalAnticonvulsantLacosamideSelectivelyEnhancesSlowInactivationofVoltage-GatedSodiumChannels
【关键词】Voltage-GatedWehypothesizedthatlacosamidemodulatesvoltage-gatedsodiumchannels(VGSCs)atclinicalconcentrations(32-100µM).Lacosamidereducedspikingevokedinculturedratcorticalneuronsby30-sdepolarizingrampsbutnotby1-sramps.Carbamazepineandphenytoinreducedspike-firinginducedbybothramps...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期EmergingPharmacological,Mechanical,andImagingStrategies
...ose—Reperfusionisthemostbeneficialofalltherapeuticstrategiesforacuteischemicstroke.However,thestandardcerebralreperfusiontreatmentofthefirstdecadeofthereperfusionera,noncontrastcomputedtomography(CT)–guided,3hours,intravenoustissueplasminogenactivator,hasmanylimitations.Thisreviewsurveysemerging...
医源资料库;在线期刊;中风学杂志;2005年第36卷第10期MolecularDeterminantsofSubstrate/InhibitorBindingtotheHumanandRabbitRenalOrganicCationTransportershOCT2andrbOCT2
...Maryland(C.C.,P.W.S.)AbstractOrganiccationtransportersareimportantfortheeliminationofmanydrugsandtoxinsfromthebody.Inthepresentstudy,substrate-transporterinteractionswereinvestigatedinChinesehamsterovarycellsstablytransfectedwitheitherthehumanorrabbitorthologsoftheprincipalorganiccationtransporterin...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第4期SalicylateBlocksLipolyticActionsofTumorNecrosisFactor-inPrimaryRatAdipocytes
【关键词】SalicylateIncreasedsystemicfreefattyacids(FFA)impairinsulinsensitivity.Inobeseanddiabeticsubjects,productionoftumornecrosisfactor-(TNF-),aproinflammatorycytokine,iselevated.TNF-hasavarietyofeffectsbyinducinginflammation,decreasingglucoseutilization,andstimulatingadipocytelipolysistore...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期Troglitazone‘srapidandsustainedactivationofERK1/2inducescellularacidosisinLLC-PK1-F+cells:physiologicalresponses
....TROinducesaseverecellularacidosis(pHi6.68±0.10vs.7.28±0.07timecontrolat4min,P<0.01),whereasphospho-ERK1/2tototalERK1/2ratioincreases3.4-fold(P<0.01).TodeterminewhetherERK1/2wasactivatedbycellularacidosisorTROwasactingviaMEK1/2toactivateERK1/2,cellswerepretreatedwithspecificinhibitorsofMEK1/2activ...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第6期EvolutionandMolecularCharacterizationofMethicillin-ResistantStaphylococcusaureusEpidemicandSporadicClonesinCordoba,Argentina
DepartamentodeBioquímicaClínica,FacultaddeCienciasQuímicas,UniversidadNacionaldeCordoba,CentrodeInvestigacionesenBioquímicaClinicaeInmunologíia(CIBICI-CONICET),CiudadUniversitaria,5000Cordoba,ArgentinaLaboratoriodeInfeccionesNosocomiales,InstitutodeSaludCarlosIII,CentroNacionaldeMicrobiología,...
医源资料库;在线期刊;微生物临床杂志;2006年第44卷第1期