Sphingosine-1-PhosphateStimulatestheFunctionalCapacityofProgenitorCellsbyActivationoftheCXCR4-DependentSignalingPathwayviatheS1P3Receptor
...】Objective-Sphingosine-1-phosphate(S1P)isabioactivelipid,whichinfluencesmigrationandproliferationofendothelialcellsthroughactivationofS1PreceptorsandhasbeenshowntosupportSDF-1inducedmigrationandbonemarrowhomingofCD34+progenitors.MethodsandResults-Here,weshowthatincubationofpatient-derivedendotheli...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第2期DifferentialEffectsofContinuousandIntermittentß-EstradiolReplacementandTamoxifenTherapyonthePreventionofGlomerulosclerosis
【摘要】FemaleROPOs/+micearepartiallyprotectedbyendogenousestrogensagainstprogressiveglomerulosclerosis(GS)duringtheirreproductiveperiod;however,ovariectomyacceleratesGSprogression.Weexaminedtheeffectsofcontinuousandintermittent17ß-estradiol(E2)replacementandtamoxifentherapyonthedevelopmen...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期LiverXreceptoragonistTO-901317upregulatesSCD1expressioninrenalproximalstraighttubule
...larefflux.Becausethekidneyplaysanimportantroleinlipidmetabolismanddyslipidemiaacceleratesrenaldamage,weinvestigatedtheeffectofTO-901317,anLXRagonist,onthegeneexpressionprofileinmousekidney.TreatmentofC57Bl/6micewithTO-901317(3mg·kg-1·day-1)for3daysresultedin51transcriptsthatweresignifi...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期Stanniocalcin-1regulatesendothelialgeneexpressionandmodulatestransendothelialmigrationofleukocytes
...motacticprotein-1-andstromal-derivedfactor-1(SDF-1)-mediatedchemotaxisanddiminisheschemokinesisinmacrophage-likeRAW264.7andU937cellsinamannerthatmayinvolveattenuationoftheintracellularcalciumsignal.STC1isstronglyinducedinthekidneyfollowingobstructiveinjury.WehypothesizedthatSTC1mayservetoattenuateth...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期SarcolemmalDamageinDystrophinDeficiencyIsModulatedbySynergisticInteractionsbetweenMechanicalandOxidative/NitrosativeStresses
...ophy,buttheprecisephysiologicalbasisformusclenecrosisremainsunclear.Todeterminewhetherdystrophin-deficientmusclesareabnormallysusceptibletooxidativeandnitricoxide(NO)-driventissuestress,ahindlimbischemia/reperfusion(I/R)modelwasused.Dystrophicmdxmiceexhibitedabnormallyhighlevelsoflipidperoxidationan...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期CholangiocyteswithMesenchymalFeaturesContributetoProgressiveHepaticFibrosisofthePolycysticKidneyRat
...hapedcholangiocytes.Theflat-shapedcholangiocytesshowedreducedimmunohistochemicalexpressionofthebiliaryepithelialmarkercytokeratin19andpositiveimmunoreactivityforvimentinandfibronectin.WhenculturedcholangiocytesofthePCKratweretreatedwithtransforminggrowthfactor(TGF)-??1,apotentinducerofepithelial-mes...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期SynergyofIL-21andIL-15inregulatingCD8+Tcellexpansionandfunction
...ondingly,theexpansionandcytotoxicityofCD8+TcellswereimpairedinIL-21R–/–mice.Moreover,invivoadministrationofIL-21incombinationwithIL-15boostedantigen-specificCD8+Tcellnumbersandresultedinacooperativeeffectontumorregression,withapparentcuresoflarge,establishedB16melanomas.Thus,ourstudiesrevealthat...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第1期Summarymeasureofdietarymusculoskeletalnutrient(calcium,vitaminD,magnesium,andphosphorus)intakesisassociatedwithlower-extremityphysicalperfor
...utritionalintakehasbeenoverlookedasapossiblecontributingfactortolower-extremityphysicalperformance,especiallyinhomeboundelderlypersons.Objectives:Ourobjectivesweretoexaminetheassociationofasummarymeasureofcalcium,vitaminD,magnesium,andphosphorusintakeswith1)theinabilitytoperformlower-extremityphysic...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第4期Small-moleculecorrectorsofdefectiveF508-CFTRcellularprocessingidentifiedbyhigh-throughputscreening
...aboratoriodiGeneticaMolecolare,IstitutoGianninaGaslini,Genova,Italy.3PrograminCellandLungBiology,HospitalforSickChildrenResearchInstitute,andUniversityofToronto,Toronto,Ontario,Canada.AbstractThemostcommoncauseofcysticfibrosis(CF)isdeletionofphenylalanine508(F508)intheCFtransmembraneconductanceregul...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期TheMonocyteChemoattractantProtein-/CognateCCChemokineReceptorSystemAffectsCellMotilityinCulturedHumanPodocytes
...srenoprotectiveeffects.Adultpodocytesareinaquiescentstate,butacquisitionofamigratory/proliferativephenotypehasbeendescribedincrescenticGNandimplicatedincrescentformation.ThecognateCCchemokinereceptor2(CCR2),theMCP-1receptor,isexpressedbyothercelltypesbesidesmonocytesandhasbeenimplicatedinbothcellpro...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期