Differentialexpressionofcollagen-andlaminin-bindingintegrinsmediatesuretericbudandinnermedullarycollectingductcelltubulogenesis
【摘要】Innermedullarycollectingducts(IMCD)areterminallydifferentiatedstructuresderivedfromtheuretericbud(UB).UBdevelopmentismediatedbychangesinthetemporalandspatialexpressionofintegrinsandtheirrespectiveligands.WedemonstratebothinvivoandinvitrothattheUBexpressespredominantlylamininreceptors(31-...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第10期SerumAmyloidAInducesContraryImmuneResponsesviaFormylPeptideReceptor-Like1inHumanMonocytes
...obeup-regulatedduringinflammatoryresponse,theroleofserumamyloidAontheregulationofinflammationandimmuneresponsehasnotbeenelucidated.WefoundthatserumamyloidAstimulatedtheproductionoftumornecrosisfactor(TNF)-andinterleukin(IL)-10,whichareproinflammatoryandanti-inflammatorycytokines,respectively,inhuman...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期ClusterinIsaSecretedMarkerforaHypoxia-InducibleFactor-IndependentFunctionofthevonHippel-LindauTumorSuppressorProtein
【摘要】GermlinemutationsinthevonHippel-Lindau(VHL)tumorsuppressorgenepredisposepeopletorenalcancer,hemangioblastomas,andpheochromocytomasinanallele-specificmanner.ThebestdocumentedfunctionoftheVHLgeneproduct(pVHL)relatestoitsabilitytopolyubiquitinate,andhencetargetfordestruction,thesubunitsofth...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第2期TheThiazolidinedionePioglitazoneAltersMitochondrialFunctioninHumanNeuron-LikeCells
...ffects,however,havenotbeencomprehensivelystudiedunderlong-termexposureconditions.Weusedthehumanneuron-likeNT2celllinetodirectlyassessthelong-termeffectsofathiazolidinedionedrug,pioglitazone,onmitochondria.Atmicromolarconcentrations,pioglitazoneincreasedmitochondrialDNA(mtDNA)content,levelsofmtDNAand...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期Tissue-TypePlasminogenActivatorandtheLow-DensityLipoproteinReceptor-RelatedProteinMediateCerebralIschemia-InducedNuclearFactor-BPathwayActivati
【摘要】Tissue-typeplasminogenactivator(tPA)isaserineproteinasefoundintheintravascularspaceandthecentralnervoussystem.Thelow-densitylipoproteinreceptor-relatedprotein(LRP)isamemberofthelow-densitylipoproteinreceptorgenefamilyfoundinneuronsandastrocytes.Cerebralischemiainducesactivationofthenucle...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期EvaluationoftheCOBASAmplicorHBVMonitorAssayandComparisonwiththeUltrasensitiveHBVHybridCapture2AssayforQuantificationofHepatitisBVirusD
AssociatedRegionalandUniversityPathologistsInstituteforClinicalandExperimentalPathologyDepartmentofPathology,UniversityofUtahMedicalCenter,SaltLakeCity,UtahABSTRACTPerformancecharacteristicsoftheCOBASAmplicorHBVMonitortest(RocheDiagnostics),whichmeasureshepatitisBvirus(HBV)DNAquantitatively,wereeval...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期TheRoleofThr139intheHumanImmunodeficiencyVirusType1ReverseTranscriptaseSensitivityto(+)-CalanolideA
RegaInstituteforMedicalResearch,KatholiekeUniversiteitLeuven,Leuven,Belgium(J.A.,E.D.C.,J.B.)DepartmentofPharmacology,UniversityofAlcale?Alcale?deHenares,Spain(F.R.-B.,F.G.)DepartmentofExperimentalMedicine,UniversityofRome“TorVergata“,Rome,Italy(F.C.-S.,C.-F.P.)InstitutodeQue猰icaMeedica,Consej...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期ofFibulin-ExpressionIsAssociatedwithBreastCancerProgression
...astcancercelllines.Fibulin-2proteinexpressionwasalsodecreasedinbreastcancertissuesamplesasevaluatedbyimmunohistochemistry.ReintroductionofFibulin-2intobreastcancercelllinesthatdonotexpressFibulin-2reducedcancercellmotilityandinvasioninvitrobuthadnoeffectoncellgrowthandadhesionproperties.Togetherwith...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylicAcid(SD-1008),aNovelJanusKinase2Inhibitor,IncreasesChemotherapySensitivityinHumanOva
【关键词】InterleukinInterleukin6andthesignaltransducerandactivatoroftranscription(STAT)3proteinshaveimportantrolesincancercellsurvivalandproliferation.RecentstudiesdemonstratethatabnormalSTAT3activationpromotestumorgrowthandsupportssurvivalofmanyhumancancers,andthus,thisproteinorthepathwayresp...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期AdrenomedullinIsaCross-TalkMoleculethatRegulatesTumorandMastCellFunctionduringHumanCarcinogenesis
【摘要】Wehavepreviouslydemonstratedthatadrenomedullin(AM)playsacriticalroleasanautocrine/paracrinetumorcellsurvivalfactor.WenowpresentevidencethatAMisanimportantregulatorofmastcell(MC)functionandthatthismodulationispotentiallyinvolvedintumorpromotion.AMinducedhistamineorß-hexosaminidasere...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期