ASingleDecoyOligodeoxynucleotidesTargetingMultipleOncoproteinsProducesStrongAnticancerEffects
...ess.Targetingasinglefactormaynotbeoptimalintherapy,becausesingleagentsarelimitedbyincompleteefficacyanddose-limitingadverseeffects.Combinationpharmacotherapyor“drugcocktail“therapyhasvalueagainstmanydiseases,includingcancers.Wereportaninnovativedecoyoligodeoxynucleotide(dODN)technologythatweterm...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期PeroxisomalMultifunctionalProtein-DeficiencyCausesMotorDeficitsandGlialLesionsintheAdultCentralNervousSystem
...eathwithinthefirstyearoflife.Incontrast,ourrecentlygeneratedMFP-2-deficientmicedidnotshowneurodevelopmentalabnormalitiesbutexhibitedaberrationsinbileacidmetabolismandoneofthreeofthemdiedearlypostnatally.Inthepostweaningperiod,allsurvivorsdevelopedprogressivemotordeficits,includingabnormalcrampingref...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期ExpressionofaDevelopmentallyRestrictedPotassiumChannelinAutoimmuneDemyelination
...dexperimentalautoimmuneencephalomyelitis,amodelofmultiplesclerosis.ConfocalmicroscopyrevealedexpressionofKv1.4inAN2-positiveoligodendrocyteprecursorcellsandpremyelinatingoligodendrocytesinvitrobutneitherinmatureoligodendrocytesnorinthespinalcordsofhealthyadultmice.Afterinductionofmyelinoligodendrocy...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期AdenosineA2Areceptoractivationattenuatesinflammationandinjuryindiabeticnephropathy
...ptor(A2AR)activationinacuterenalinjury.WesoughttoextendthesestudiesanddeterminetheefficacyofA2ARagonistsinachronicmodelofrenalinjury.WehypothesizedthatA2Aagonistsmediaterenaltissueprotectionindiabeticnephropathybyreducingglomerularinflammation.Diabeteswasinducedwithsingleintravenousinjectionofstrept...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第4期Age-dependentregulationofvasopressinV1areceptorsinpreglomerularvesselsfromthespontaneouslyhypertensiverat
...ngspontaneouslyhypertensiverats(SHR).TheageregulationoftheV1areceptorwasexaminedinpreglomerularvesselsfrom5-,10-,20-,and70-wk-oldSHRusingnormotensiveWistar-Kyotorats(WKY)ascontrols.Real-timePCRandligandbindingwereusedforanalysisofreceptorexpression,andthechangeincytosoliccalciumconcentrationduringst...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第5期NF-B2isrequiredfortheestablishmentofcentraltolerancethroughanAire-dependentpathway
1DepartmentofPathologyandCommitteeonImmunology,UniversityofChicago,Chicago,Illinois,USA.2DivisionofMolecularImmunology,LaJollaInstituteforAllergyandImmunology,SanDiego,California,USA.3ImmuneActivationSection,LaboratoryofImmuneRegulation,NationalInstituteofAllergyandInfectiousDiseases,NIH,Bethesda,Ma...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期EvidenceforFunctionalP2X4/P2X7HeteromericReceptors
...ralimportantrolesinimmunecellregulation,suchascytokinerelease,apoptosis,andmicrobialkilling.AlthoughP2X7receptorsarefrequentlycoexpressedwithanothersubtypeofP2Xreceptor,P2X4,theyarebelievednottoformheteromericassembliesbuttofunctiononlyashomomers.Bothreceptorsplayaroleinneuropathicpain;therefore,und...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期Meetingcalciumrecommendationsduringmiddlechildhoodreflectsmother-daughterbeveragechoicesandpredictsbonemineralstatus
JenniferOFisher,DianeCMitchell,HelenSmiciklas-Wright,MichelleLManninoandLeannLBirch1FromtheDepartmentofPediatrics,BaylorCollegeofMedicine,USDepartmentofAgriculture/AgriculturalResearchServiceChildrensNutritionResearchCenter,Houston(JOF),andtheDepartmentsofNutritionalSciences(DCMandHS-W)andHuma...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第4期OligodendrocytesAreaMajorTargetoftheToxicityofSpongiogenicMurineRetroviruses
...sesFrCasEandMoloneyMLV-ts1causenoninflammatoryspongiformneurodegenerationinmice,manifestedclinicallybyprogressivespasticityandparalysis.Neuronshavebeenthoughttobetheprimarytargetoftoxicityoftheseviruses.Howevertheneuronsthemselvesappearnottobeinfected,andthepossibleindirectmechanismsdrivingtheneuron...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期HighGlucose-InducedThioredoxin-InteractingProteininRenalProximalTubuleCellsIsIndependentofTransformingGrowthFactor-ß
【摘要】Hyperglycemiaisacausativefactorinthepathogenesisofdiabeticnephropathy.Here,wedemonstratethetranscriptionalprofilesofthehumanproximaltubulecellline(HK-2cells)exposedtohighglucoseusingcDNAmicroarrayanalysis.Thioredoxin-interactingprotein(Txnip)wasthegenemostsignificantlyincreasedamong10str...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期