PropertiesregulatingthenatureoftheplasmacytoiddendriticcellresponsetoToll-likereceptor9activation
...orporation,Berkeley,CA947102DepartmentofPharmaceuticalSciences,UniversityofMichigan,AnnArbor,MI48109Humanplasmacytoiddendriticcells(PDCs)canproduceinterferon(IFN)-and/ormatureandparticipateintheadaptiveimmuneresponse.ThreeclassesofCpGoligonucleotideligandsforToll-likereceptor(TLR)9canbedistinguished...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期TherapeuticEffectofVasoactiveIntestinalPeptideonExperimentalAutoimmuneEncephalomyelitis
...hecurrentstudydescribesapossiblenewstrategyforthetreatmentofMS,basedontheadministrationofthevasoactiveintestinalpeptide(VIP),awell-knownimmunosuppressiveneuropeptide.TreatmentwithVIPsignificantlyreducedincidenceandseverityofexperimentalautoimmuneencephalomyelitis(EAE),inaMS-relatedrodentmodelsystem....
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期InvolvementofEndothelialCDduringinVivoAngiogenesis
...titsroleintheformationofbloodvesselsinvivohasnotbeenestablished.InCD44-nullmice,vascularizationofMatrigelimplantsandtumorandwoundangiogenesiswereinhibited.Leukocyteaccumulationduringtumorgrowthandwoundhealinginwild-typeandCD44-nullmicewerecomparable,andreconstitutionofCD44-nullmicewithwild-typebonem...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期InhibitionofTRPP3ChannelbyAmilorideandAnalogs
【关键词】Inhibitionamiloride,withIC50valuesof0.14,1.1,10.5,and143µM,respectively.Theinhibitionpotencypositivelycorrelatedwiththesizeofinhibitors.Usingcell-attachedpatchclamping,weshowedthattheamilorideanalogsdecreasetheopenprobabilityandmeanopentimebuthavenoeffectonsingle-channelconducta...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期DistributionoftheH+/peptidetransporterPepT1inhumanintestine:up-regulatedexpressioninthecolonicmucosaofpatientswithshort-bowelsyndrome
...orResearchResources,NIH(TRZandKU);andtheSpanishInstitutodeSaludCarlosIIIdelMinisteriodeSanidadyConsumo97/5082(toCF-E).3AddressreprintrequeststoTRZiegler,SuiteGG-23,GeneralClinicalResearchCenter,EmoryUniversityHospital,1364CliftonRoad,Atlanta,GA30322.E-mail:tzieg01{at}emory.edu.ABSTRACTBackground:Int...
医源资料库;在线期刊;美国临床营养学杂志;2002年75卷第5期ADP-RibosylationFactor-LikeIsInvolvedinKidneyandPhotoreceptorDevelopment
【摘要】ADP-ribosylationfactor-like3(Arl3)isamemberofasmallsubfamilyofG-proteinsinvolvedinmembrane-associatedvesicularandintracellulartraffickingprocesses.GeneticstudiesinLeishmaniahaveshownthattheArl3homologisessentialforflagellumbiogenesis.Mutationsinarelatedhumanfamilymember,Arl6,resultinBard...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期InductionofApoptosisbyCrambeneProtectsMiceagainstAcutePancreatitisviaAnti-InflammatoryPathways
...sdemonstratedthatinductionofpancreaticacinarcellapoptosisbycrambeneprotectsmiceagainstacutepancreatitis.However,littleisknownabouthowtheinductionofapoptosisreducestheseverityofacutepancreatitis.Becausetheclearanceofapoptoticcellsmightsuppressinflammationandcriticallyregulateimmuneresponses,wepostula...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期LackofpendrinHCO3-transportelevatesvestibularendolymphatic[Ca2+]byinhibitionofacid-sensitiveTRPV5andTRPV6channels
...inthevestibularsystemandthatTRPV5expressionisstimulatedby1,25-dihydroxyvitaminD3,asalsoreportedinkidney.TRPV5/6channelsareknowntobeinhibitedbyextracellularacidicpH.EndolymphaticpH,[Ca2+],andtransepithelialpotentialoftheutricleweremeasuredinCl-/HCO3-exchangerpendrin(SLC26A4)knockoutmiceinvivo.Slc26a4...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期TempolreducesoxidativestressandrestoresrenaldopamineD1-likereceptor-Gproteincouplingandfunctioninhyperglycemicrats
【摘要】DopamineviaactivationofrenalD1-likereceptorsinhibitstheactivitiesofNa-K-ATPaseandNa/Hexchangerandsubsequentlyincreasessodiumexcretion.Decreasedrenaldopamineproductionandsodiumexcretionareassociatedwithhyperglycemicconditions.WehaveearlierreportedD1-likereceptor-Gproteinuncouplingandreduc...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第7期RegulationofrenininmicewithCrerecombinase-mediateddeletionofGproteinGsinjuxtaglomerularcells
【摘要】BycrossingmicewithexpressionofCrerecombinaseundercontroloftheendogenousreninpromoter(SequeiraLopezML,PentzES,NomasaT,SmithiesO,GomezRA.DevCell6:719-728,2004)withmiceinwhichexon1oftheGnasgenewasflankedbyloxPsites(ChenM,GavrilovaO,LiuJ,XieT,DengC,NguyenAT,NackersLM,LorenzoJ,ShenL,Weinstein...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期