Bcell–deficientNOD.H-2h4micehaveCD4+CD25+Tregulatorycellsthatinhibitthedevelopmentofspontaneousautoimmunethyroiditis
...umbia,MO65212Wild-type(WT)NOD.H-2h4micedevelopspontaneousautoimmunethyroiditis(SAT)whengiven0.05%NaIintheirdrinkingwater,whereasBcell–deficientNOD.H-2h4miceareSATresistant.TotestthehypothesisthatresistanceofBcell–deficientmicetoSATwasduetotheactivityofregulatoryCD4+CD25+T(Treg)cellsactivatedifau...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期Disabled-HeterozygousMiceArePredisposedtoEndometrialandOvarianTumorigenesisandExhibitSex-BiasedEmbryonicLethalityinap-NullBackground
...摘要】Disabled-2(Dab2)isaphosphoproteininvolvedincellularsignaltransductionandendocytictrafficking.TheexpressionofDab2isfrequentlylostorsuppressedinseveralepithelialtumors,andstudiesofitscellularfunctionandgrowthsuppressiveactivitywhenre-expressedincancercellsledtothesuggestionthatDab2isatumorsup...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期HIV-1–specificCD4+Tlymphocyteturnoverandactivationincreaseuponviralrebound
...ldDepartmentofClinicalMedicine,UniversityofOxford,Oxford,UnitedKingdom.2InstituteforMicrobiology,Eidgen?ssischeTechnischeHochschuleZurich,Zurich,Switzerland.3DepartmentofMedicine,ImperialCollege,St.Mary’sHospital,London,UnitedKingdom.AbstractHIV-specificCD4+Thelperlymphocytesarepreferredtargetsfor...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期RepressionofHumanGSTA1byInterleukin-1IsMediatedbyVariantHepaticNuclearFactor-1C
【关键词】RepressionDown-regulationofglutathionetransferaseA1(GSTA1)expressionhasprofoundimplicationsincytoprotectionagainsttoxicby-productsoflipidperoxidationproducedduringinflammation.Weinvestigatedtheroleofhepaticnuclearfactor1(HNF-1)inrepressionofhumanGSTA1expressionbyinterleukin(IL)-1inCac...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期LeishmaniaPromastigoteMembraneAntigen-BasedEnzyme-LinkedImmunosorbentAssayandImmunoblottingforDifferentialDiagnosisofIndianPost-Kala-AzarDermal
InfectiousDiseasesGroup,IndianInstituteofChemicalBiologyDepartmentofTropicalMedicine,SchoolofTropicalMedicine,Calcutta,IndiaABSTRACTDiagnosisofpost-kala-azardermalleishmaniasis(PKDL),causedbyLeishmaniadonovani,isdifficult,asthedermallesionsareofseveraltypesandresemblethosecausedbyotherskindiseases,e...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期VEGF-Ainducestumorandsentinellymphnodelymphangiogenesisandpromoteslymphaticmetastasis
...MassachusettsGeneralHospitalandHarvardMedicalSchool,Charlestown,MA021293InstituteofPharmaceuticalSciences,SwissFederalInstituteofTechnologyZurich,CH-8093Zurich,Switzerland4DepartmentofPathology,BethIsraelDeaconessMedicalCenter,HarvardMedicalSchool,Boston,MA02215Themechanismsoftumormetastasistothesen...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第7期PathogenesisofArylHydrocarbonReceptor-MediatedDevelopmentofLymphomaIsAssociatedwithIncreasedCyclooxygenase-Expression
...pidemiologicalstudiesindicatethatexposuretoenvironmentalpollutantssuchaspesticidesanddioxinsleadstothepathogenesisoflymphomaandleukemia.Here,weshowthatactivationofthearylhydrocarbonreceptor(AhR)by2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)resultedinlossoftheprogrammedcelldeath(apoptosis)responseinthre...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期IncreasedexpressionofENaCsubunitsandincreasedapicaltargetingofAQP2inthekidneysofspontaneouslyhypertensiverats
...词】hypertensionTheWaterandSaltResearchCenter,UniversityofAarhus,andInstituteofAnatomy,UniversityofAarhus,Aarhus,DenmarkDepartmentofInternalMedicine,ChonnamNationalUniversityMedicalSchool,Gwangju,KoreaDepartmentofBiochemistryandCellBiology,SchoolofMedicine,KyungpookNationalUniversity,Taegu,KoreaLa...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期PolysaccharidePurifiedfromGanodermalucidumInducesGeneExpressionChangesinHumanDendriticCellsandPromotesTHelper1ImmuneResponseinBALB/cMice
...nmoiety.Inthisstudy,weexaminedtheeffectsofPS-Gonhumanmonocyte-deriveddendriticcells(DCs)withmicroarrayanalysisbyHumanGenomeU133Plus2.0GeneChip.IncomparingmeansignalvaluesbetweenPS-G-treatedDCswithuntreatedDCs,3477(17%)probesetswereup-regulated,and4418(19%)probesetsweredown-regulatedafterPS-Gtreatmen...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期ThechemokineKCregulatesHGF-stimulatedepithelialcellmorphogenesis
【摘要】Hepatocytegrowthfactor(HGF)inducesmigration,proliferation,andbranchinginrenalepithelialcellsfromtheinnermedullarycollectingduct(mIMCD-3cells).MicroarrayanalysisafterHGFstimulationofthesecellsrevealedupregulationofthechemokineKC.WefoundthatboththemessageandproteinlevelsofKCareincreasedaft...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第3期