μ-OpioidReceptorActivationModulatesTransientReceptorPotentialVanilloid1(TRPV1)CurrentsinSensoryNeuronsinAModelofInflammatoryPain
...ypersensitivityassociatedwithtissueinflammation.Inthisstudy,weinvestigatedµ-opioidreceptorandTRPV1expressioninprimaryafferentneuronsinthedorsalrootganglion(DRG)incompleteFreund‘sadjuvant(CFA)-inducedpawinflammation.Inaddition,thepresentstudyexaminedwhethertheactivityofTRPV1inDRGneuronscanbei...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期NaturalandEnantiomericEtiocholanoloneInteractwithDistinctSitesontheRat122LGABAAReceptor
...rfulthanetiocholanoloneatproducingpotentiation.AtalowGABAconcentration(0.5µM,
Isletß-Cell-SpecificTCellsCanUseDifferentHomingMechanismstoInfiltrateandDestroyPancreaticIslets
...filtrationbyTcellsdependsontheadhesionmoleculesexpressedinthesesitesandonhomingreceptorsexpressedbytheTcells.Here,wehavestudiedwhichformofprimingcanenableTcellstohometopancreaticislets.Tothisend,wehaveusedtransgenicmiceexpressingthemodelautoantigenovalbumininpancreaticisletsandtransgenicovalbumin-sp...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期DistinctRolesofEphrin-B2ForwardandEphB4ReverseSignalinginEndothelialCells
...n,whereasEphB4reversesignalingbythetransmembraneephrin-B2liganddoesnot.Cellmigrationisalsoinhibitedonimmobilizedephrin-B2-FcbutnotonEphB4-Fcprotein.Conclusions—Ephrin-B2forwardsignalingandEphB4reversesignalingdifferentiallyaffectcelladhesionandmigrationbetweenarterialandvenousendothelialcells.KeyW...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2003年第23卷第2期EffectsofangiotensinIIontheCO2dependenceofHCO3
...onnecticutABSTRACTPreviousauthorsshowedthat,atlowdoses,bothbasolateralandluminalANGIIincreasetheproximaltubule‘sHCO3reabsorptionrate(JHCO3).Usingout-of-equilibriumCO2/HCO3solutions,wedemonstratedthatbasolateralCO2increasesJHCO3.Here,weexamineinteractionsbetweenANGIIandCO2inisolated,perfusedrabbitS...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第2期SelectivegrowthofmucolyticbacteriaincludingClostridiumperfringensinaneonatalpigletmodeloftotalparenteralnutrition
...yDrive,Urbana,IL61801.E-mail:hgaskins{at}uiuc.edu.ABSTRACTBackground:Compromisedbarrierfunctionandintestinalinflammationarecommoncomplicationsoftotalparenteralnutrition(TPN).Objective:WetestedthehypothesisthatthelackofenteralnutrientsinTPNmightselectcommensalorpathogenicbacteriathatusemucusasasubstr...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第5期CharacterizationandComparisonofNicotineandCotinineMetabolisminVitroandinVivoinDBA/2andC57BL/6Mice
...olizedtocotinineinvitrobytwoenzymaticsites.Thehigh-affinitysitesexhibitedsimilarparameters(Km,10.7±4.8versus11.4±3.6µM;Vmax,0.58±0.18versus0.50±0.07nmol/min/mgforDBA/2andC57BL/6,respectively).Invivo,theeliminationhalflivesofnicotine(1mg/kg,s.c.)werealsosimilarbetwee...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期PersistentDetectionofVaricella-ZosterVirusDNAinaPreviouslyHealthyChildafterSevereChickenpox
EmmaChildren‘sHospital,AcademicMedicalCenter,Amsterdam,TheNetherlandsDepartmentofExperimentalImmunology,AcademicMedicalCenter,Amsterdam,TheNetherlandsDepartmentofMedicalMicrobiology,SectionofVirology,AcademicMedicalCenter,Amsterdam,TheNetherlandsABSTRACTInimmunocompetentchildrenwithprimaryvaricell...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期COX-2inhibitionpreventsdownregulationofkeyrenalwaterandsodiumtransportproteinsinresponsetobilateralureteralobstruction
...angesintheexpressionofrenalaquaporins(AQPs)andsodiumtransportproteins.Toexaminetheroleofprostaglandininthisresponse,weinvestigatedwhether24-hBUOchangedtheexpressionofcyclooxygenases(COX-1and-2)inthekidneyandtestedtheeffectoftheselectiveCOX-2inhibitorparecoxib(5mg・kg1・day1viaosmoticminipumps)onAQ...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第9期RetinoblastomaPathwayDysregulationCausesDNAMethyltransferaseOverexpressioninCancerviaMAD-MediatedInhibitionoftheAnaphase-PromotingComplex
【摘要】WehaveexaminedthemechanismofnormalDNAmethyltransferase1(DNMT1)degradationaswellasitsmechanismofdysregulationincancer.WehavepreviouslyreportedthatDNMT1proteinlevelswereelevatedandabnormallystabilizedbecauseofdefectivedegradationthroughitsN-terminaldestructiondomain.Here,wereportthatDNMT1w...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期