TheMonocyteChemoattractantProtein-/CognateCCChemokineReceptorSystemAffectsCellMotilityinCulturedHumanPodocytes
【摘要】Increscenticglomerulonephritis(GN),monocytechemoattractantprotein-1(MCP-1)isoverexpressedwithintheglomeruli,andMCP-1blockadehasrenoprotectiveeffects.Adultpodocytesareinaquiescentstate,butacquisitionofamigratory/proliferativephenotypehasbeendescribedincrescenticGNandimplicatedincrescentfo...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期T-Cell-MediatedDisruptionoftheNeuronalMicrotubuleNetwork
【摘要】Duringthecourseofthecentralnervoussystemautoimmunediseasemultiplesclerosis(MS),damagetomyelinleadstoneurologicaldeficitsattributabletodemyelinationandconductionfailure.However,accumulatingevidencehasindicatedthataxonalinjuryisalsoapredictorofMSclinicaldisease.UsingtheanimalmodelofMS,expe...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期Cyclicalmodulationofsphingosine-1-phosphatereceptor1surfaceexpressionduringlymphocyterecirculationandrelationshiptolymphoidorgantransit
1HowardHughesMedicalInstituteandDepartmentofMicrobiologyandImmunology,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA941432NationalInstituteofDiabetesandDigestiveKidneyDiseases,NationalInstitutesofHealth,Bethesda,MD20892Sphingosine-1-phosphatereceptor1(S1P1)wasrecentlyshowntoberequiredforlymphoc...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第2期HyaluronanInducestheSelectiveAccumulationofMatrix-andCell-AssociatedProteoglycansbyMesangialCells
【摘要】Mesangialcells(MCs)areessentialfornormalrenalfunctionthroughthesynthesisoftheirownextracellularmatrix,whichformsthestructuralsupportoftherenalglomerulus.Inmanyrenaldiseasesthismatrixisreorganizedinresponsetoavarietyofcytokinesandgrowthfactors.Thisstudyexaminesproteoglycanandhyaluronan(HA...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期Induciblebronchus-associatedlymphoidtissue(iBALT)inpatientswithpulmonarycomplicationsofrheumatoidarthritis
1TrudeauInstitute,SaranacLake,NewYork,USA.2InstitutoNacionaldeEnfermedadesRespiratorias,MexicoCity,Mexico.Addresscorrespondenceto:TroyD.Randall,TrudeauInstitute,SaranacLake,NewYork12983,USA.Phone:(518)891-3080;Fax:(518)891-5126;E-mail:trandall@trudeauinstitute.org.ReceivedforpublicationApril5,2006,a...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第12期CharacterizationofCytolethalDistendingToxinofCampylobacterSpeciesIsolatedfromCaptiveMacaqueMonkeys
DepartmentofVeterinaryandBiomedicalSciencesVeterinaryDiagnosticCenter,UniversityofNebraska-Lincoln,Lincoln,NebraskaTulaneNationalPrimateResearchCenter,Covington,LouisianaABSTRACTAnassociationbetweencertainCampylobacterspeciesandenterocolitisinhumansandnonhumanprimatesiswellestablished,buttheassociat...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期Interleukin-Receptor-MediatedActivationofSignalTransducerandActivatorofTranscription-(STAT)PromotesChoroidalNeovascularization
...roinflammatorycytokine,issuggestedtobeariskfactorforchoroidalneovascularization(CNV)becauseofitsincreasedlevelsintheserumofpatientswithage-relatedmaculardegeneration;however,theroleofIL-6inCNVhasnotbeendefined.ThepresentstudyrevealsthecriticalcontributionofIL-6signalinganditsdownstreamSTAT3pathwayto...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期AntibodyGDGSelectedagainstEmbryonicGlycosaminoglycansDefinesChondroitinSulfate-EDomainsHighlyUp-RegulatedinOvarianCancerandInvolvedinVascula
【摘要】Chondroitinsulfate(CS)isabundantlypresentinthetumorstroma,andtumor-specificCSmodificationsmightbepotentialtargetstoinfluencetumordevelopment.Weappliedthephagedisplaytechnologytoselectantibodiesthatidentifythesetumor-specificCSmodifications.AntibodyGD3G7wasselectedagainstembryonicglycosam...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期DimerizationRegionofSolubleGuanylateCyclaseCharacterizedbyBimolecularFluorescenceComplementationinVivo
【关键词】DimerizationTheubiquitouslyexpressednitricoxide(NO)receptorsolubleguanylatecyclase(sGC)playsakeyroleinsignaltransduction.BindingofNOtotheN-terminalprosthetichememoietyofsGCresultsin200-foldactivationoftheenzymeandanincreasedconversionofGTPintothesecondmessengercGMP.sGCexistsasaheterod...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期PharmacologicalCharacterizationofaNovelNonpeptideAntagonistforFormylPeptideReceptor-Like1
【关键词】Receptor-Like1Aseriesofquinazolinonederivativesweresynthesizedbasedonahitcompoundidentifiedfromahigh-throughputscreeningcampaigntargetingthehumanformylpeptidereceptor-like1(FPRL1).Basedonstructure-activityrelationshipanalysis,wefoundthatsubstitutionontheparapositionofthe2-phenylgroupo...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期