ExacerbationofAlbuminuriaandRenalFibrosisinSubtotalRenalAblationModelofAdiponectin-KnockoutMice
【摘要】Objective—Obesityisrecognizedincreasinglyasamajorriskfactorforkidneydisease.Wereportedpreviouslythatplasmaadiponectinlevelsweredecreasedinobesity,andthatadiponectinhaddefensivepropertiesagainsttype2diabetesandhypertension.Inthisstudy,weinvestigatedtheroleofadiponectinforkidneydisea...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第9期Small-MoleculeScreenIdentifiesInhibitorsofaHumanIntestinalCalcium-ActivatedChlorideChannel
【关键词】Small-Molecule95%iodideinfluxinHT-29cellsinresponsetomultiplecalcium-elevatingagonists,includingthapsigargin,withoutinhibitionofcalciumelevation,calcium-calmodulinkinaseIIactivation,orcysticfibrosistransmembraneconductanceregulatorchloridechannels.Thesecompoundsalsoinhibitedcalcium-de...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期可溶性syndecan-1对人多发性骨髓瘤细胞体外的生物学作用
...备,可溶性syndecan-1分子的纯化及鉴定 由于XG-2细胞可分泌高水平的可溶性syndecan-1[7],因此制备该细胞的培养上清:调整XG-2细胞浓度为5×105ml-1,用含IL-6(3ng/ml)和10%FCS的RPMI1640培养基,37℃,5%CO2培养3d,常规离心收集培养上清...
合作平台;医学论文;临床医学与专科论文;检验医学Sodiumchannelmutationsinepilepsyandotherneurologicaldisorders
DepartmentofHumanGenetics,UniversityofMichigan,AnnArbor,Michigan,USA.AbstractSincethefirstmutationsoftheneuronalsodiumchannelSCN1Awereidentified5yearsago,morethan150mutationshavebeendescribedinpatientswithepilepsy.Manyaresporadicmutationsandcauselossoffunction,whichdemonstrateshaploinsufficiencyofSC...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期Glibenclamidepreventsincreasedextracellularmatrixformationinducedbyhighglucoseconcentrationinmesangialcells
【摘要】Otherthanstimulationofcellcontractility,littleisknownaboutthepotentialmetaboliceffectsinducedbysulfonylureas,independentlyofinsulinaction.Previousstudiesfromourlaboratorydemonstratedcompleteabrogationofglomerulosclerosisinanexperimentalmodeloftype1diabeteschronically(9mo)treatedwithlow-d...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期ClassicInterleukin-ReceptorSignalingandInterleukin-trans-SignalingDifferentiallyControlAngiotensinII-DependentHypertensionCardiacSignalTransduce
【摘要】Interleukin(IL)-6actsviaareceptorcomplexconsistingofthecognateIL-6receptor(IL-6R)orthesolubleIL-6receptor(sIL-6R)andglycoprotein130(gp130).Here,weinvestigatedtheroleoftheseIL-6Rcomponentsinhypertensionandvascularhypertrophyinmice.Angiotensin(Ang)II(1.1mg/kg/day)causedhypertensionandcardi...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期曹雪涛院士最新文章解析免疫应答
...大学,浙江大学医学院等处的研究人员发表了题为“ProteinTyrosinePhosphatasewithProline-Glutamine-Serine-Threonine-RichMotifsNegativelyRegulatesTLR-TriggeredInnateResponsesbySelectivelyInhibitingIκBKinaseβ/NF-κBActivation”的文章,解析了一种具有特殊结构的磷酸...
行业资讯;临床快报;免疫系统高校教师中不典型病毒性心肌炎39例分析
...:目的分析39例不典型病毒性心肌炎的诊断、治疗过程以提高诊疗水平,防止漏诊和误诊。方法结合病史、心电图、心肌酶谱做出诊断,采用休息、抗病毒、营养心肌、用中药黄芪等综合治疗。结果39例病人经治疗均痊愈。结论不...
医源资料库;在线期刊;中国热带医学杂志;2005年第5卷第3期PyogenicLiverAbscessDuetoRhodococcusequiinanImmunocompetentHost
FaculdadedeCiênciasMedicas,UniversidadedoEstadodoRiodeJaneiro,RiodeJaneiro,BrazilABSTRACTAcaseofpyogenicliverabscess(PLA)duetoRhodococcusequiinanimmunocompetentindividualwassuccessfullytreatedbycombiningsurgeryandantibiotics.TheR.equi-targetedantimicrobialagentserythromycinandrifampinwereusedonlyaf...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期CultivationofNeisseriagonorrhoeaeinLiquidMediaandDeterminationofItsInVitroSusceptibilitiestoQuinolones
DepartmentofUrology,GifuUniversitySchoolofMedicine,Gifu501-1194,JapanDiscoveryResearchLaboratories,KyorinPharmaceuticalCo.,Ltd.,Tochigi329-0114,JapanABSTRACTThecultivationofNeisseriagonorrhoeaebyuseoffastidiousbroth(FB)wasevaluated.FBwasfoundtobeabletosupportthegrowthofallN.gonorrhoeaestrainstestedi...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期