Trans-cyclopropanationofmycolicacidsontrehalosedimycolatesuppressesMycobacteriumtuberculosis–inducedinflammationandvirulence
...icacidsbutsynthesizesintactratiosofallmycolicacidsubclasses(30).WeinfectedC57BL/6JandBALB/CmicewithWTM.tuberculosis,acmaA2nullmutant,andageneticallycomplementedcmaA2mutantcarryingasinglecopyofWTcmaA2expressedfromitsnativepromoter.BothBALB/CandC57BL/6Jmicereceivedeither100CFUsbyaerosolor105or106CFUsb...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期IL-20IsExpressedinAtherosclerosisPlaquesandPromotesAtherosclerosisinApolipoproteinE-DeficientMice
...ionofIL-20anditsreceptorsintheatheroscleroticlesionsinapoE-/-miceandnormalC57BL/6mice.WefoundthatIL-20wasupregulatedintheatherosclerosisplaqueofapoE-/-micecomparedwithnormalC57BL/6mice(supplementalFigureIAitoAj,availableonlineathttp://atvb.ahajournals.org).StrongimmunoreactivitywasdetectedforbothIL-...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第9期TheroleofherpesvirusentrymediatorasanegativeregulatorofTcell–mediatedresponses
...hecompletecodingsequencefortheextracellulardomain.(D)BloodwascollectedfromC57BL/6(WT)andHVEM–/–mice,andwhitebloodcellswerestainedwithbiotin-labeledratanti-HVEMmAbandstreptavidin-CyChrome.(E)LymphnodecellsfromWTandHVEM–/–micewerestainedwithPE–anti-CD3,biotin-labeledratanti-HVEMantibody,ands...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期H-2Kb基因转移诱导小鼠心肌移植免疫耐受
...过逆转录病毒载体介导的基因转移技术,将供体小鼠(C57BL/6)的H-2Kb基因(小鼠MHC-Ⅰ类基因)导入到受体小鼠(BALB/c)的造血细胞。结果 H-2Kb基因可以稳定地整合进小鼠造血细胞的基因内,并在受体内表达较长时间。正常...
合作平台;医学论文;临床医学与专科论文;检验医学IL-2在体内抗弓形虫作用机制的研究
...。 1 材料和方法 1.1 实验动物、虫株及细胞 C57BL/6纯系雌性小鼠6~8周龄,购自白求恩医科大学实验动物部,经PCR检测试剂盒检测为弓形虫阴性;弓形虫RH株,为常用标准强毒株,小鼠腹腔传代;Yac-1细胞,白求恩医...
合作平台;医学论文;临床医学与专科论文;检验医学Minimummethioninerequirementandcysteinesparingofmethionineinhealthyschool-agechildren
...rogenbalanceofwomenmaintainedonvariouslevelsofmethionineandcysteine.JNutr1957;64:99111.DiBuonoM,WykesLJ,BallRO,PencharzPB.Dietarycysteinereducesthemethioninerequirementinmen.AmJClinNutr2001;74:7616.KurpadAV,ReganMM,VaralakshmiS,GnanouJ,LingappaA,YoungVR.Effectofcysteineonthemethioninereq...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第5期BovineLactoferricinInhibitsBasicFibroblastGrowthFactor-andVascularEndothelialGrowthFactor-InducedAngiogenesisbyCompetingforHeparin-LikeBindin
...inhibitedbothbFGF-andVEGF165-inducedangiogenesisinMatrigelplugsimplantedinC57BL/6mice.Inaddition,LfcinBinhibitedtheinvitroproliferationandmigrationofhumanumbilicalveinendothelialcells(HUVECs)inresponsetobFGForVEGF165butwasnotcytotoxictoHUVECs.Rather,LfcinBcomplexedwithheparin-likestructuresontheHUVE...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期EffectofHepatitisCVirusGenotypeonCD4+TCellCountinaCohortofAntiretroviral-NaiveHIV-1InfectedIndividuals
...4(P=.02,Kruskal-Wallistest);themean(±SD)follow-upperiodforallpatientswas4.57(8.33)months.Riskcategorieswereinjectiondruguse(255[84.4%]patients),homosexualcontact(11[3.6%]patients),andheterosexualcontact(27[8.9%]patients).Inourbasicmodelthatadjustedforagealone,absoluteCD4+Tcellcountsweresignificantl...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第16期RoleofatyrosinekinaseintheCO2-inducedstimulationofHCO3-reabsorptionbyrabbitS2proximaltubules
...n(solution4,5,or6)containinggenistein(345834,Calbiochem,LaJolla,CA);PP2(529573,Calbiochem);PD168393(513033,Calbiochem);orBPIQ-I(203696,Calbiochem)plus1:20,000DMSO(D-5534,Sigma,St.Louis,MO).Wethenrepeatedtheprocedureoutlinedforthefirstcollectionperiods.WegeneratedOOECO2/HCO3-solutions(solution5and6)b...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期替米沙坦联合硝酸酯类治疗慢性心力衰竭63例临床观察
...分为治疗组与对照组。治疗组63例,男39例,女24例;年龄57~76岁,平均66岁;心功能均Ⅳ级;肺心病43例,冠心病12例,高心病8例。对照组63例,男38例,女25例;年龄56~74岁,平均65岁;心功能Ⅲ级41例,Ⅳ级22例;肺心病40例,冠心病14...
医源资料库;在线期刊;中华现代内科学杂志;2009年第6卷第7期