RoleofEndogenousSerotonininModulatingGenioglossusMuscleActivityinAwakeandSleepingRats
...rtmentsofMedicineandPhysiology,UniversityofToronto,Toronto,CanadaABSTRACTRationale:Exogenousserotoninatthehypoglossalmotornucleus(HMN)stimulatesgenioglossus(GG)muscleactivity.However,whetherendogenousserotonincontributestoGGactivationacrossnaturalsleep–wakestateshasnotbeendetermined,butisrelevantg...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第11期Site-SpecificInhibitionofGlomerulonephritisProgressionbyTargetedDeliveryofDexamethasonetoGlomerularEndothelium
【关键词】Site-SpecificGlomerulonephritisrepresentsagroupofrenaldiseaseswithglomerularinflammationasacommonpathologicfinding.Becauseoftheunderlyingimmunologiccharacterofthesedisorders,theyarefrequentlytreatedwithglucocorticoidsandcytotoxicimmunosuppressiveagents.Althougheffective,useofthesecomp...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期EpithelialCellAdhesionMoleculeMorethanaCarcinomaMarkerandAdhesionMolecule
...celladhesionmolecule(EpCAM,CD326)isaglycoproteinof40kdthatwasoriginallyidentifiedasamarkerforcarcinoma,attributabletoitshighexpressiononrapidlyproliferatingtumorsofepithelialorigin.NormalepitheliaexpressEpCAMatavariablebutgenerallylowerlevelthancarcinomacells.Inearlystudies,EpCAMwasproposedtobeacell...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期ProteinKinaseC-DependentMitochondrialTranslocationofProapoptoticProteinBaxonActivationofInducibleNitric-OxideSynthaseinRostralVentrolateralM
【关键词】ProteinSympatheticpremotorneuronsforthemaintenanceofvasomotortonearelocatedinrostralventrolateralmedulla(RVLM).Wedemonstratedpreviouslythatoverproductionofnitricoxide(NO)byinducibleNOsynthase(iNOS)inRVLM,leadingtocaspase3-dependentapoptoticcelldeath,playsapivotalroleincardiovascularde...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期DoxycyclineAltersVascularSmoothMuscleCellAdhesionMigrationandReorganizationofFibrillarCollagenMatrices
...juredbloodvesselsisdependentonsmoothmusclecellsandmatrixmetalloproteinaseactivity.Doxycyclineisabroadspectrummatrixmetalloproteinaseinhibitorthatisunderinvestigationforthetreatmentofacutecoronarysyndromesandaneurysms.Inthepresentstudy,weexaminethemechanismsbywhichdoxycyclineinhibitssmoothmusclecellr...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第5期OligodendrocytesAreaMajorTargetoftheToxicityofSpongiogenicMurineRetroviruses
...rovirusesFrCasEandMoloneyMLV-ts1causenoninflammatoryspongiformneurodegenerationinmice,manifestedclinicallybyprogressivespasticityandparalysis.Neuronshavebeenthoughttobetheprimarytargetoftoxicityoftheseviruses.Howevertheneuronsthemselvesappearnottobeinfected,andthepossibleindirectmechanismsdrivingthe...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期AllostericModulationoftheCannabinoidCB1Receptor
SchoolofMedicalSciences,InstituteofMedicalSciences,UniversityofAberdeen,Aberdeen,Scotland(M.R.P.,G.L.B.,A.T.,L.A.S.,R.G.P.,R.A.R.)OrganonResearch,Newhouse,Lanarkshire,Scotland(M.E.,R.G.,A.M.,L.M.,G.G.,G.W.,P.W.,J.M.,F.T.,P.C.)DepartmentofPharmacology,UniversityofMelbourne,Parkville,Australia(A.C.)Ab...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期UpdateinTuberculosis2005
...ong,ChinaPATHOGENESISANDIMMUNITYOFTUBERCULOSISAmongthereportedgenomicalterationsofMycobacteriumtuberculosis,thoseinvolvingthephospholipaseCgeneareofsignificantinterest(1,2).TalaricoandcolleaguespublishedanearlierinvestigationregardingthegeneticdiversityoffourM.tuberculosisphospholipaseC–encodingge...
医源资料库;在线期刊;美国呼吸和危急护理医学;2006年第173卷第5期Glycemicindexanddisease
...posiumheldatExperimentalBiology2001,Orlando,FL,1April2001.3SupportedbytheNationalInstitutesofHealth(grantP30DK26687).4AddressreprintrequeststoFXavierPi-Sunyer,ObesityResearchCenter,St.Luke‘sRooseveltHospitalCenter,1111AmsterdamAvenue,NewYork,NY10025.E-mail:fxp1{at}columbia.edu.ABSTRACTIthasb...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第1期Uterinesensitization-associatedgene–1(USAG-1),anovelBMPantagonistexpressedinthekidney,acceleratestubularinjury
1COEFormationforGenomicAnalysisofDiseaseModelAnimalswithMultipleGeneticAlterations,2DepartmentofCardiovascularMedicine,and3DepartmentofOralandMaxillofacialSurgery,GraduateSchoolofMedicine,KyotoUniversity,Kyoto,Japan.4LaboratoryAnimalResourceCenter,InstituteofBasicMedicalSciences,UniversityofTsukuba,...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期