Thrombin-ActivatableFibrinolysisInhibitorDeficiencyAttenuatesBleomycin-InducedLungFibrosis
...aredbleomycin-inducedlungfibrosisinTAFI-deficient,heterozygous,andwild-typemice.Theanimalsweresacrificed21daysafterbleomycinadministration,andmarkersoflungfibrosisandinflammationweremeasured.Thebronchoalveolarlavagefluidlevelsoftotalprotein,neutrophilproteases(elastase,myeloperoxidase),cytokines(tum...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期SelectivityofcyclooxygenaseisoformactivityandprostanoidproductioninnormalanddiseasedHan:SPRD-cyratkidneys
...altered.WiththeuseoftheHan:Sprague-Dawley-cyrat,theaimofthisstudywastodeterminetherelativecontributionofrenalCOXisoforms(protein,geneexpression,andactivity)onrenalprostanoidproduction[thromboxaneB2(TXB2,stablemetaboliteofTXA2),prostaglandinE2(PGE2),and6-keto-prostaglandinF1(6-keto-PGF1,stablemetabol...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第4期COX-2activitydeterminesthelevelofreninexpressionbutisdispensableforacuteupregulationofreninexpressioninratkidneys
...2)inthecontrolofreninisstillamatterofdebate,sincestudieswithCOX-2-deficientmiceorwithCOX-2inhibitorsproducedconflictingfindings.Therefore,westudiedtheeffectoftheCOX-2inhibitorSC-58236ontheregulationofthereninsysteminadultratkidneys.RenocorticaltissuelevelsandurinaryexcretionofPGE2werereducedto65and4...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第6期ProstaglandinE2isapotentinhibitorofepithelial-to-mesenchymaltransition:interactionwithhepatocytegrowthfactor
...thepathogenesisoftubulointerstitialfibrosis.EMTistypicallyinducedbytransforminggrowthfactor-1(TGF-1)andinhibitedbyhepatocytegrowthfactor(HGF).Thepresentstudywasundertakentoevaluatethepotentialroleofcyclooxygenase(COX)-2-derivedPGE2inregulationofEMTinculturedMadin-Darbycaninekidney(MDCK)cells,inthese...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期Developmentofage-dependentglomerularlesionsingalectin-3/AGE-receptor-3knockoutmice
...developmentofglomerularlesionsinaginggalectin-3knockout(KO)vs.wild-type(WT)miceandtheirrelationtotheincreasedAGElevelsandoxidativestresscharacterizingtheagingprocess.KOmiceshowedsignificantlymorepronouncedage-dependentincreasesinproteinuria,albuminuria,glomerularsclerosis,andglomerularandmesangialar...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第10期PostlipopolysaccharideOxidativeDamageofMitochondrialDNA
...HODSRESULTSDISCUSSIONREFERENCESSelectedstructuralandfunctionalalterationsofmitochondriainducedbybacteriallipopolysaccharide(LPS)wereinvestigatedonthebasisofthehypothesisthatLPSinitiateshepaticmitochondrialDNA(mtDNA)damagebyoxidativemechanisms.AfterasingleintraperitonealinjectionofEscherichiacoliLPS,...
医源资料库;在线期刊;美国呼吸和危急护理医学;2003年第167卷第4期IntercellularAdhesionMolecule-IsRequiredfortheEarlyFormationofGranulomasandParticipatesintheResistanceofMicetotheInfectionwiththeFungus
【摘要】ThemigrationofleukocytestoinflammatorysiteselicitedbyParacoccidioidesbrasiliensisissupposedtobecoordinatedbycytokinesandchemokines.Here,weinvestigatedtheroleofintercellularadhesionmolecule-1(ICAM-1)inrecruitinginflammatorycellstolungsofmiceinfectedwithP.brasiliensisandindeterminingtheout...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期FormationandMetabolismofPrebeta-Migrating,Lipid-PoorApolipoproteinA-I
...ey,Australia.CorrespondencetoProfPhilipBarter,TheHeartResearchInstitute,145MissendenRd,Camperdown,Sydney,NSW2050,Australia.E-mailp.barter@hri.org.auAbstractThepreferredextracellularacceptorofcellphospholipidsandunesterifiedcholesterolintheprocessmediatedbytheATP-bindingcassetteA1(ABCA1)transporteris...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第3期MurineModelstoEvaluateNovelandConventionalTherapeuticStrategiesforCancer
...linicalcorrelationshavebeenidentifiedwithseveralanimalmodels,inadditiontolimitationsandaneedforimprovement.Modelinadequaciesincludeexperimentaldesignsthatdonotincorporatebiologicalconcepts,drugpharmacology,ortoxicity.Ascitesmodelshavebeenfoundtoidentifydrugsactiveagainstrapidlydividingtumors;however...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第3期DeficiencyofEndothelialNitric-OxideSynthaseConfersSusceptibilitytoDiabeticNephropathyinNephropathy-ResistantInbredMice
...ations.However,functionalconsequencesarestillincompletelyunderstood.TodeterminetheroleofeNOS-derivednitricoxide(NO)indiabeticnephropathy,weinduceddiabetesineNOSknockout(KO)andwild-type(WT)miceontheC57BL6background,usinglow-dosestreptozotocininjection,andweinvestigatedtheirglomerularphenotypeatupto20...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期