InhibitionofInterferon-SignalinginOligodendrogliaDelaysCoronavirusClearancewithoutAlteringDemyelination
【摘要】Infectionofthecentralnervoussystem(CNS)bytheneurotropicJHMstrainofmousehepatitisvirus(JHMV)inducesanacuteencephalomyelitisassociatedwithdemyelination.Toexaminetheanti-viraland/orregulatoryroleofinterferon-(IFN-)signalinginthecellthatsynthesizesandmaintainsthemyelinsheath,weanalyzedJHMVpa...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期PropertiesregulatingthenatureoftheplasmacytoiddendriticcellresponsetoToll-likereceptor9activation
1DynavaxTechnologiesCorporation,Berkeley,CA947102DepartmentofPharmaceuticalSciences,UniversityofMichigan,AnnArbor,MI48109Humanplasmacytoiddendriticcells(PDCs)canproduceinterferon(IFN)-and/ormatureandparticipateintheadaptiveimmuneresponse.ThreeclassesofCpGoligonucleotideligandsforToll-likereceptor(TL...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期Cardiacmastcell-derivedreninpromoteslocalangiotensinformation,norepinephrinerelease,andarrhythmiasinischemia/reperfusion
...illMedicalCollegeofCornellUniversity,NewYork,NewYork,USA.AbstractHavingidentifiedreninincardiacmastcells,weassessedwhetheritsreleaseleadstocardiacdysfunction.InLangendorff-perfusedguineapighearts,mastcelldegranulationwithcompound48/80releasedAngI–formingactivity.Thisactivitywasblockedbytheselectiv...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期TherapeuticEffectofVasoactiveIntestinalPeptideonExperimentalAutoimmuneEncephalomyelitis
【摘要】Multiplesclerosis(MS)isadisablinginflammatory,autoimmunedemyelinatingdiseaseofthecentralnervoussystem.Despiteintensiveinvestigation,themechanismsofdiseasepathogenesisremainunclear,andcurativetherapiesareunavailableforMS.ThecurrentstudydescribesapossiblenewstrategyforthetreatmentofMS,base...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期InhibitoryRoleofCDintheProgressionofExperimentalAutoimmuneEncephalomyelitisbyRegulatingCytokineResponse
【摘要】Experimentalautoimmuneencephalomyelitis(EAE)isaninflammatorydemyelinatingdiseaseofthecentralnervesystemthatisconsideredaThelpertype1(Th1)-mediatedautoimmunedisease.EAEcurrentlyservesasanexperimentalanimalmodelformultiplesclerosisinhuman.Cytokines,suchasinterferon-andinterleukin-10,playak...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期Hepatocytegrowthfactorinkidneyfibrosis:therapeuticpotentialandmechanismsofaction
...摘要】Hepatocytegrowthfactor(HGF)isapleiotropicfactorthatplaysanimperativeroleintubularrepairandregenerationafteracuterenalinjury.GrowingevidenceindicatesthatHGFisalsoanendogenousrenoprotectivefactorthatpossessesapotentantifibroticability.HGFpreventstheinitiationandprogressionofchronicrenalfibros...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第7期RoleofProteinKinaseCandItsAdaptorProteinp62inVoltage-GatedPotassiumChannelModulationinPulmonaryArteries
【关键词】RoleVoltage-gatedpotassium(KV)channelsplayanessentialroleinregulatingpulmonaryarteryfunction,andtheyunderpinthephenomenonofhypoxicpulmonaryvasoconstriction.Pulmonaryhypertensionischaracterizedbyinappropriatevasoconstriction,vascularremodeling,anddysfunctionalKVchannels.Inthecurrentstu...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期InvolvementofEndothelialCDduringinVivoAngiogenesis
...4,acell-surfacereceptorforhyaluronan,hasbeenimplicatedinendothelialcellfunctions,butitsroleintheformationofbloodvesselsinvivohasnotbeenestablished.InCD44-nullmice,vascularizationofMatrigelimplantsandtumorandwoundangiogenesiswereinhibited.Leukocyteaccumulationduringtumorgrowthandwoundhealinginwild-ty...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期InductionofApoptosisbyCrambeneProtectsMiceagainstAcutePancreatitisviaAnti-InflammatoryPathways
...摘要】Apoptosisisateleologicallybeneficialformofcelldeathinacutepancreatitis.Ourpreviousworkhasdemonstratedthatinductionofpancreaticacinarcellapoptosisbycrambeneprotectsmiceagainstacutepancreatitis.However,littleisknownabouthowtheinductionofapoptosisreducestheseverityofacutepancreatitis.Becauseth...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期Corticotropin-ReleasingHormoneModulatesHumanTrophoblastInvasionthroughCarcinoembryonicAntigen-RelatedCellAdhesionMolecule-Regulation
【摘要】Abnormalitiesintheprocessoftrophoblastinvasionmayresultinabnormalplacentation.Boththeembryonictrophoblastandmaternaldeciduaproducecorticotropin-releasinghormone(CRH),whichpromotesimplantation.Carcinoembryonicantigen-relatedcelladhesionmolecule1(CEACAM1),whichisexpressedinextravilloustrop...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期