InCD+T-Cell-InducedDiabetesMacrophagesAretheFinalEffectorCellsthatMediateIsletß-CellKilling
...iabetesusingthediabetogenicCD4+BDC2.5T-cellclonewasestablished.TransferofactivatedBDCTcellsintoNOD.scidmiceresultedindiabeteswithinaweek,characterizedbystronginflammatoryreaction.Electronmicrographsofpancreasdepictedmacrophagesinclosecontactwithßcellsthatexhibitedsignsofapoptosis.Transferintoi...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期TheRoleofPlateletsinLeukocyteRecruitmentinChronicContactHypersensitivityInducedbyRepeatedElicitation
【摘要】Plateletshavebeenshowntobeimportantininflammation,buttheirroleinchronicallergicdermatitisremainsunclear.Toinvestigatetheroleofplateletsinamousemodelofchroniccontacthypersensitivityinducedbyrepeatedelicitation,miceweresensitizedandrepeatedlyelicitedinearswithhapten,withorwithoutplateletde...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期Renalcompensationtochronichypoxichypercapnia:downregulationofpendrinandadaptationoftheproximaltubule
【摘要】Themolecularbasisfortherenalcompensationtorespiratoryacidosisandspecificallytheroleofpendrininthisconditionareunclear.Therefore,westudiedtheadaptationoftheproximaltubuleandthecollectingducttorespiratoryacidosis.MaleWistar-Hannoverratswereexposedtoeitherhypercapniaandhypoxia[8%CO2and13%O2...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第4期第三节 刺灸法
...长约8厘米,宽约5厘米,厚约2-3厘米的纸块。用线如“井”字形扎紧,做成纸垫。练针时,左手执垫,右手拇、食、中指前后交替地捻动针柄,穿透纸垫,反复练习。(图10-64) 2.棉团练针法 用棉花做衬,用布将棉花...
医源资料库;医源图书馆;教材类;中医学基础2011年全国优秀博士学位论文名单公布
...波频段ROF系统设计李建强林金桐北京邮电大学2011032抽水井附近非达西流的理论研究与数值模拟文章黄冠华中国农业大学2011033乳铁蛋白成骨活性及对去卵巢大鼠骨质疏松症治疗作用的研究郭慧媛任发政中国农业大学2011034尿素、生...
医学教育;科教新闻LeptinneutralizationinterfereswithpathogenicTcellautoreactivityinautoimmuneencephalomyelitis
1IstitutodiEndocrinologiaeOncologiaSperimentale,ConsiglioNazionaledelleRicerche(IEOS-CNR),Naples,Italy.2CattedradiImmunologia,DipartimentodiBiologiaePatologiaCellulareeMolecolare,UniversitàdiNapoli“FedericoII“,Naples,Italy.3AutoimmunityandToleranceLaboratory,DepartmentofMedicine,UniversityofCal...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期S1PmodulatorFTY720limitsmatrixexpansioninacuteanti-thy1mesangioproliferativeglomerulonephritis
【摘要】FTY720isanovelimmunemodulatorwhoseprimaryactionisbloodlymphocytedepletionthroughinteractionwithsphingosine-1-phosphate(S1P)receptors.ThepresentstudyanalyzestheeffectofFTY720onboththeearlymesangialcellinjuryandthesubsequentmatrixexpansionphaseofexperimentalmesangioproliferativeglomerulone...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第6期IdentificationoftheSubstrateBindingRegionofVesicularMonoamineTransporter-2(VMAT-2)UsingIodoaminoflisopololasaNovelPhotoprobe
【关键词】IdentificationMonoamines,suchasserotonin,dopamine,andnorepinephrine,aresequesteredintosynapticvesiclesbyspecifictransporters(vesicularmonoaminetransporter-2;VMAT2)usingenergyfromanelectrochemicalprotongradientacrossthevesiclemembranes.Basedonourpreviousstudiesusingphotoaffinity-labeli...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期OverexpressionoftheTranscriptionFactorGATA-EnhancestheDevelopmentofPulmonaryFibrosis
...onstratedthatTh2cytokines,suchasinterleukin-4andinterleukin-13,enhancefibroticprocessesbyactivatingfibroblastproliferationandcollagenproduction,whereasinterferon-,aTh1cytokine,inhibitstheseprocesses.Th1andTh2cellsbothdifferentiatefromcommonTprecursorcells,withtranscriptionfactorGATA-3akeyregulatorof...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期Sphingosine1-PhosphateReceptorsMediatetheLipid-InducedcAMPAccumulationthroughCyclooxygenase-2/ProstaglandinI2PathwayinHumanCoronaryArterySmoot
LaboratoryofSignalTransduction,InstituteforMolecularandCellularRegulation,GunmaUniversity,Maebashi,Japan(A.D.,H.T.,M.K.,M.T.,K.S.,C.M.,F.O.)DepartmentofMicrobiology,FacultyofPharmaceuticalSciences,HealthSciencesUniversityofHokkaido,Ishikari-Tobetsu,Hokkaido,Japan(H.N.,K.T.)AbstractSphingosine1-phosp...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第4期