AblationoftheTamm-Horsfallproteingeneincreasessusceptibilityofmicetobladdercolonizationbytype1-fimbriatedEscherichiacoli
...edbyanintricatearrayofdefensemechanismsoftheurinarysystem.Inthisstudy,weexaminedtheinvivoroleofTamm-Horsfallprotein(THP),themostabundanturinaryprotein,ininnateurinarydefense.WegeneticallyablatedthemouseTHPgeneandfoundthatTHPdeficiencypredisposesmicetobladderinfectionsbytype1-fimbriatedE.coli.Inocula...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第4期MiceLackingNeutrophilElastaseAreResistanttoBleomycin-InducedPulmonaryFibrosis
...eutrophilelastaseinpulmonaryinflammationandfibrosis,neutrophilelastase-nullmicewereintratracheallyinstilledwithbleomycin.Inneutrophilelastase-nullmice,biochemicalandmorphologicalcharacteristicsofpulmonaryfibrosiswereattenuatedforatleast60daysafterbleomycinadministrationdespiteatypicalresponsetobleom...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期Cholesterol-Dependentand-IndependentCD40InternalizationandSignalingActivationinCardiovascularEndothelialCells
...ardiovascularendothelialcells(ECs).MethodsandResults—Usingfluorescentmicroscopyandflowcytometry,wedemonstratedthatsolubleCD40LandagonisticantibodyG28.5inducedCD40internalizationviaclathrin-independentpathway.Furthermore,depletionofcholesterolbymethyl-β-cyclodextrin(MCD)orsiRNAknockdownofc...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第9期CannabinoidReceptor-MediatedApoptosisInducedbyR(+)-MethanandamideandWin55,212-2IsAssociatedwithCeramideAccumulationandp38ActivationinMantleC
...d.InductionofapoptosisaftertreatmentwiththesyntheticagonistsR(+)-methanandamide[R(+)-MA]andWin55,212-2(Win55;(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo-[1,2,3-d,e]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone)wasdependentonbothcannabinoidreceptors,becausepretreatmentwithN-(piperid...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期TheReducedFolateCarrierGeneIsaNovelSelectableMarkerforRecombinantProteinOverexpression
...olatecofactorsareone-carbondonorsessentialforthebiosynthesisofpurinesandthymidylate.Mammaliancellsaredevoidoffolatebiosynthesisandarethereforefolateauxotrophsthattakeupfolatevitaminsprimarilyviathereducedfolatecarrier(RFC).Inthisstudy,weshowedthatthehumanRFC(hRFC)genecanserveasanovelselectablemarker...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期Glucose-evokedalterationsinconnexin43-mediatedcell-to-cellcommunicationinhumancollectingduct:apossibleroleindiabeticnephropathy
...o25mM),producedatime-dependent(48h)increaseinCx43proteinexpression.Thetransmissionrateoftouch-evokedCa2+transientsbetweencoupledcellswasacceleratedafterexposuretohighglucose,providingafunctionalcorrelatetoincreasedCx43expression.ThesedatasuggestapivotalroleforCx43-mediatedgapjunctionsinthesynchroniz...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第11期SelectiveActivationofLiverXReceptorsbyAcanthoicAcid-RelatedDiterpenes
【关键词】SelectiveTerpenoidsconstitutealargefamilyofnaturalsteroidsthatarewidelydistributedinplantsandinsects.Weinvestigatedtheeffectsofaseriesofditerpenesstructurallyrelatedtoacanthoicacidinmacrophagefunctions.WefoundthatditerpeneswithdifferentsubstitutionsattheC4positioninringAarepotentactiv...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期CofilinmediatesATPdepletion-inducedendothelialcellactinalterations
【摘要】Ischemiaandsepsisleadtoendothelialcelldamage,resultingincompromisedmicrovascularflowinmanyorgans.Muchremainstobedeterminedregardingtheintracellularstructuraleventsthatleadtoendothelialcelldysfunction.Toinvestigatepotentialactincytoskeletal-relatedmechanisms,ATPdepletionwasinducedinmousep...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第6期ClC-5:roleinendocytosisintheproximaltubule
...altubule.Dent’sdiseasepatientswithmutantClC-5channelsandClC-5knockout(KO)micebothhavelowmolecularmassproteinuria.TofurtherunderstandthefunctionofClC-5,endocytosiswasstudiedinLLC-PK1cellsandprimaryculturesofproximaltubulecellsfromwild-type(WT)andClC-5KOkidneys.Endocytosisintheproximaltubulecellsfro...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第8期LipoxinARegulatesBronchialEpithelialCellResponsestoAcidInjury
...)aspivotalmediatorsinvivoforresolutionofacid-initiatedacutelunginjury.Toexamineprotectivemechanismsforthesemediatorsintheairway,wedevelopedaninvitromodelofacidinjurybytransientlyexposingwell-differentiatednormalhumanbronchialepithelialcellstohydrochloricacid.Transmissionelectronmicroscopyrevealedsel...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期