Soydietworsensheartdiseaseinmice
...fColoradoatBoulder,Boulder,Colorado,USA.AbstractWereportthatdietarymodificationfromasoy-baseddiettoacasein-baseddietradicallyimprovesdiseaseindicatorsandcardiacfunctioninatransgenicmousemodelofhypertrophiccardiomyopathy.Onasoydiet,maleswithamutationinthe-myosinheavychaingeneprogresstodilationandhear...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期TransfectionofDrug-SpecificT-CellReceptorsintoHybridomaCells:ToolstoMonitorDrugInteractionwithT-CellReceptorsandEvaluateCross-Reactivityto
【关键词】TransfectionInthecontextofdrughypersensitivity,ourgrouphasrecentlyproposedanewmodelbasedonthestructuralfeaturesofdrugs(pharmacologicalinteractionwithimmunereceptors;p-iconcept)toexplaintheirrecognitionbyTcells.Accordingtothisconcept,evenchemicallyinertdrugscanstimulateTcellsbecausecer...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期AggressiveVeryLow-DensityLipoprotein(VLDL)andLDLLoweringbyGeneTransferoftheVLDLReceptorCombinedwithaLow-FatDietRegimenInducesRegression
...ascularmortality.WhereasVLDL/LDLloweringcausesregressionofearlyatheroscleroticlesions,lessisknownabouttheeffectsofaggressivelipidloweringonregressionofadvancedcomplexlesions.WethereforeinvestigatedtheeffectofVLDL/LDLloweringonpre-existinglesionsinLDLreceptor-deficientmice.Micefedahigh-fatdietfor16we...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期Calciumwaveoftubuloglomerularfeedback
【摘要】ATPreleasefrommaculadensa(MD)cellsintotheinterstitiumofthejuxtaglomerular(JG)apparatus(JGA)isanintegralcomponentofthetubuloglomerularfeedback(TGF)mechanismthatcontrolstheglomerularfiltrationrate.BecausethecellsoftheJGAexpressanumberofcalcium-coupledpurinergicreceptors,thesestudiestestedt...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期QuantificationofCalcificationinAtheroscleroticLesions
...01,6565FanninSt,Houston,TX77030.E-mailmorriset@bcm.tmc.eduAbstractCalcificationcanbedepositedthroughoutthevasculatureinseveralformsofcalciumphosphate,includingcalciumhydroxyapatite(CHA).Calciumaccumulationinarteriesbymineralizationandcalciumlossfrombonebyosteoporosisoftencoexist,andvascularcalcifica...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第8期RenalvascularandtubulointerstitialinflammationandproliferationinCyp1a1-Ren2transgenicratswithinducibleANGII-dependentmalignanthypertension
...leANGII-dependentmalignanthypertension[TGR(Cyp1a1Ren2)]weregeneratedbyinsertingthemouseRen2reningeneintothegenomeoftherat.ThepresentstudywasperformedtoassessrenalmorphologicalchangesoccurringduringthedevelopmentofANGII-dependentmalignanthypertensionintheserats.MaleCyp1a1-Ren2rats(n=10)werefednormalr...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第6期GenomicDiversityinCampylobacterjejuni:IdentificationofC.jejuni81-176-SpecificGenes
...eterinaryPathobiology,CollegeofVeterinaryMedicine,OklahomaStateUniversity,Stillwater,Oklahoma74078Dynamique,EvolutionetExpressiondeGenomesdeMicroorganismes,UniversiteLouisPasteur/CNRSFRE2326,67000Strasbourg,FranceDepartmentofGenetics,UniversityofNorthCarolina,ChapelHill,NorthCarolina27599-7264ABSTRA...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第5期GlycerylTrinitrateInhibitsHypoxia/Reoxygenation-InducedApoptosisintheSyncytiotrophoblastoftheHumanPlacenta
【摘要】Damageoftheplacentaresultingfromischemia-reperfusionisimportanttothepathophysiologyofpreeclampsia.Hereweinvestigatedwhetherlowconcentrationsofglyceryltrinitrate(GTN),anitricoxidemimeticwithanti-apoptoticproperties,inhibithypoxia/reoxygenation-inducedapoptosisinthesyncytiotrophoblastofcho...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第3期TransientReceptorPotentialMelastatin7IonChannelsRegulateMagnesiumHomeostasisinVascularSmoothMuscleCells
theCIHRMultidisciplinaryResearchGrouponHypertension,ClinicalResearchInstituteofMontreal,Canada.AbstractMagnesiummodulatesvascularsmoothmusclecell(VSMC)function.However,molecularmechanismsregulatingVSMCMg2+remainunknown.Usingbiochemical,pharmacological,andgenetictools,theroleoftransientreceptorpotent...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第2期Calmodulin-StimulatedAdenylylCyclaseGeneDeletionAffectsMorphineResponses
【关键词】CyclaseGeneDeletionAffectsMorphineResponsesTodefinetherolesofthecalmodulin-stimulatedadenylylcyclases(AC1andAC8)inmorphine-inducedanalgesia,tolerance,physicaldependence,andconditionedplacepreference,weusedmicehavingtargeteddisruptionsofeithertheAC1orAC8genesorbothgenes[doubleknockoutm...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期