InternalizationofrenaltypeIIcNa-Picotransporterinresponsetoahigh-phosphatediet
...a,JapanABSTRACTDietaryphosphatelevelsregulatetherenalbrush-bordertypeIIaNa-Picotransporter.AnotherNa-Picotransporter,typeIIc,colocalizeswithtypeIIaNa-Picotransporterintheapicalmembraneofrenalproximaltubularcells.Thegoalofthepresentstudywastodeterminewhetherdietaryphosphatelevelsalsorapidlyregulateth...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第3期混合脐带血浆对脐血单个核细胞增殖及凋亡的影响
...CDK2和CDK4表达的影响;姬姆萨染色形态学观察和流式细胞术PI染色法检测CBP对细胞凋亡的作用。结果(1)加入10%CBP12h后BrdU检测值与对照组(10%FBS)相比无统计学意义;而24h后的检测值与对照组相比P0.01,显著高于对照组;加入20%CBP后1...
资料库;在线期刊;中华现代内科学杂志;2004年第1卷第1期肱动脉充血前后搏动指数变化评价血液透析患者血管内皮功能的研究
...患者和32例正常人肱动脉充血反应前后的搏动指数变化(△PI%)及内径的变化(△D%),比较两组间差异有无显著性。分析血液透析组△PI%与△D%的相关性,及它们分别与年龄、收缩压、舒张压、透析时间及颈动脉内中膜厚度(IMT)的相关...
医源资料库;在线期刊;中华现代影像学杂志;2011年第8卷第3期PhysiologicalConcentrationsofInsulinInduceEndothelin-DependentVasoconstrictionofSkeletalMuscleResistanceArteriesinthePresenceofTumorNecrosis
...hroughinhibitionofinsulin-mediatedactivationofphosphatidylinositol3-kinase(PI3K)andAkt,whicharecrucialstepsininsulin-mediatedeNOSactivation.12,13Inskeletalmuscleresistancearteries,wehaveshownpreviouslythatthevasodilatoreffectsofinsulinaremediatedbyPI3KandeNOS.9Incontrast,vasoconstrictoreffectsofinsu...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第2期EstrogenReceptorActivationofPhosphoinositide-3Kinase,Akt,andNitricOxideSignalinginCerebralBloodVessels:RapidandLong-TermEffects
...nreceptorregulationofnitricoxideproductionbyvascularendotheliummayinvolverapid,membrane-initiatedsignalingpathwaysinadditiontoclassicgenomicmechanisms.Inthisstudy,wedemonstrateusingintactcerebralbloodvesselsthat17-estradiolrapidlyactivatesendothelialnitric-oxidesynthase(eNOS)viaaphosphoinositide-3(P...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第1期GST-pi与p53蛋白表达在肠腺癌和增生性病变中的意义
【摘要】目的研究胎盘型谷胱甘肽转移酶(GST-pi)与p53蛋白在肠腺癌和增生性病变中表达的意义。方法应用S-P免疫组化法检测36例肠腺癌、16例肠腺瘤伴非典型增生、20例肠腺瘤、10例肠息肉组织中GST-pi与p53蛋白表达的关系。结果G...
医源资料库;在线期刊;中华实用医药杂志;2005年第5卷第21期TheThree-SubstitutedIndolinoneCyclin-DependentKinase2Inhibitor3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one(SU9516)Kill
...acells.ExposureofU937andotherleukemiacellstoSU9516concentrations5µMrapidly(i.e.,within4h)inducedcytochromecrelease,Baxmitochondrialtranslocation,andapoptosisinassociationwithpronounceddown-regulationoftheantiapoptoticproteinMcl-1.Theseeffectswereassociatedwithinhibitionofphosphorylationoftheca...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期Insulin-LikeGrowthFactor-IRegulatesProliferationandOsteoblasticDifferentiationofCalcifyingVascularCellsviaExtracellularSignal-RegulatedProtein
...acellularsignal-regulatedproteinkinase(ERK)andphosphatidylinositol3-kinase(PI3K)pathways.InhibitionofeithertheERKorPI3KpathwayreversedIGF-IeffectsonCVCproliferationandAPactivity,suggestingacommondownstreamtarget.OverexpressionofERKactivatoralsomimickedIGF-Iinhibitionoflipopolysaccharide-inducedAPact...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第3期PresynapticInhibitionviaaPhospholipaseC-andPhosphatidylinositolBisphosphate-DependentRegulationofNeuronalCa2+Channels
...mMATPor0.2mMdioctanoylphosphatidylinositol-4,5-bisphosphatewasincludedinthepipettesolution.Incontrast,theeffectofbradykininwasentirelyreversibleinperforated-patchrecordingsbutbecameirreversiblewhentheresynthesisofphosphatidylinositol-4,5-bisphosphatewasblocked.Thus,theinhibitionofCa2+currentsbybrady...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期InductionofVascularPermeabilitybytheSphingosine-1-PhosphateReceptor–2(S1P2R)anditsDownstreamEffectorsROCKandPTEN
...ptorstoregulateavarietyofphysiologicalresponses.WhereasS1P1RactivatesGi-andPI-3-kinase–dependentsignalstoinhibitvascularpermeability,therelatedS1P2RinhibitsthePI-3-kinasepathwaybycouplingtotheRho-dependentactivationofthePTENphosphatase.However,cellularconsequencesofS1P2Rsignalinginthevascularc...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第6期