MonitoringInteractionsbetweenReceptorTyrosineKinasesandTheirDownstreamEffectorProteinsinLivingCellsUsingBioluminescenceResonanceEnergyTransf
...sinekinaseassays(Olive,2004;Minor,2005).Ashifttowardtheuseofmorewhole-cell-basedRTKassaysisexpectedtoleadtoabetterpredictionoftheclinicaloutcomeofnewdrugcandidates.Furthermore,cancerdrugsareincreasinglydesignedtotargetspecificcell-signalingpathways,becausecancertypesshowsignalingpathway-specificdere...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期中药治疗功能性便秘的探究
...香、槟榔、乌药等顺气行滞;咽喉肿痛,痈肿疮疡,风热痒疹诸症而大便干结者,可与连翘、浮萍等伍用,其功益彰。(3)菟丝子性甘微温,能补肾阴阳,补阴而不滋腻[6]。组方:菟丝子25g,生地黄15g,槟榔8g。如宗气虚弱,...
医源资料库;在线期刊;中华现代中医学杂志;2007年第3卷第3期综合康复治疗陈旧性寰枢椎关节脱位
...湾产DIGIT-TRA900绳式头带水平牵引,牵引结束后采用北京产BA2008-Ⅲ型电脑中频仪治疗,疼痛缓解后调整项部肌力训练,辅以中成药活血化瘀。结果13例患者平均住院治疗时间26.8天,最短1例住院7天,齿状突未恢复正常位置,余12例...
医源资料库;在线期刊;中华医药杂志;2009年第9卷第7期国医大师周仲瑛讲中医临证技巧(十二)——药物配伍之同类相须
...寒发热、无汗、头痛、身痛,并可祛肌表之风,而治皮肤痒疹。 3.麻黄、细辛 麻黄发汗解表,宣肺平喘;细辛散寒止痛,温肺化饮,多用于寒邪犯表,痰饮阻肺,恶寒身热,无汗身痛,喘哮咳逆,痰多清稀者。 4.川...
求医问药;专家门诊;名家医案PersistentNF-BactivationinrenalepithelialcellsinamousemodelofHIV-associatednephropathy
...ssaryhosttranscriptionfactorforHIV-1geneexpression,andithasbeenshownthatNF-Bactivityisdysregulatedinmanynaturallyinfectedcelltypes.Weshowherethatrenalglomerularepithelialcells(podocytes)expressingtheHIV-1genome,similartoinfectedimmunecells,alsohaveadysregulatedandpersistentactivationofNF-B.Althoughp...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第2期攀枝花地区鱼腥草挥发性化学成分的气相色谱-质谱联用分析
...鱼腥草挥发油气相色谱-质谱水蒸气蒸馏法 鱼腥草HerbaHouttuynia为三白草科植物蕺菜HouttuyniacordataThunb的带根全草,又名臭腥草、臭牡丹、臭灵丹、辣子草等,多年生草本,生长于阴湿地或水边,味辛、微温,分布西北、华北、...
药品天地;专业药学;实验技术;色谱技术;色谱论文GeneticandAntigenicVariabilityofHumanRespiratorySyncytialVirus(GroupsAandB)IsolatedoverSevenConsecutiveSeasonsinArgentina(1995to2001)
...ix-wellvinylplates(Costar,Cambridge,MA)werecoatedwithproteinextractsandincubatedovernightat4°C.Plateswereblockedwith1%bovineserumalbumininphosphate-bufferedsaline.DilutionsofMAbsin0.1%bovineserumalbumininphosphate-bufferedsalinewereaddedtotheplates.Boundantibodiesweredetectedafterincubationwithbiot...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第5期AutoregulatoryResponseandCO2ReactivityoftheBasilarArtery
...bstractTopAbstractIntroductionSubjectsandMethodsResultsDiscussionReferencesBackgroundandPurpose—TranscranialDopplerhasbeenextensivelyusedtomeasurecerebrovascularcontrolmechanisms,includingautoregulationinhumansandinpatientswithcerebrovasculardiseases.Therehavebeensufficientreportsonthemeasuremento...
医源资料库;在线期刊;中风学杂志;2001年第1卷第1期RoleoftheOuter-SheetinDivalentCationModulationof7NicotinicReceptors
...tweenthestrandswouldalteractivationbyagonists.Usinganondesensitizing7mutantbackground(L247T),weidentifiedonemutantpair,K144C+T198C,thatexhibitedauniquecharacteristic:itwasfullyactivatedbydivalentcations(Ca2+,Ba2+,orSr2+)intheabsenceofacetylcholine(ACh).Divalent-evokedcurrentswereblockedbythe7antagon...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期ProteinKinaseC-DependentMitochondrialTranslocationofProapoptoticProteinBaxonActivationofInducibleNitric-OxideSynthaseinRostralVentrolateralM
...passproteinkinaseC(PKC)activation,whichtriggersactivationandtranslocationofBaxthatopensmitochondrialpermeabilitytransitionporebyinteractingwithadeninenucleotidetranslocase(ANT)orvoltage-dependentanionprotein(VDAC),followedbycytosolicreleaseofcytochromec.InSprague-Dawleyrats,coimmunoprecipitationandW...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期