cIAP2isaubiquitinproteinligaseforBCL10andisdysregulatedinmucosa-associatedlymphoidtissuelymphomas
...mediatedNF-Bactivation,theroleofcIAP2isnotclear.HereweshowthatcIAP2isaubiquitinligase(E3)ofBCL10andtargetsitfordegradation,inhibitingantigenreceptor–mediatedcytokineproduction.cIAP2-MALT1lacksE3activity,andconcomitantly,theBCL10proteinisstabilizedinMALTlymphomasharboringthisfusion.Furthermore,BCL1...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期茚地普隆的合成工艺改进
...】药物化学;制备;化学合成AnimprovedsynthesismethodofindilplonSHAOQiu-rong,WUJin-chang.ShundeEntry-ExitInspectionandQuarantineBureauAgriculturalandChemicalProductsLaboratory,Shunde528303,China【Abstract】ObjectiveTosynthesisindiplon.MethodsThesynthesisstartedfromcommerciallyavailableof2-a...
医源资料库;在线期刊;中华实用医药杂志;2006年第6卷第20期DifferentialEffectsofGq,G14,andG15onVascularSmoothMuscleCellSurvivalandGeneExpressionProfiles
...ource(T.T.L.,K.G.),EmoryUniversitySchoolofMedicine,Atlanta,GeorgiaAbstractGqfamilymembers(Gq,G11,G14,andG15/16)stimulatephospholipaseC(PLC)andinositollipidsignalingbutdiffermarkedlyinaminoacidsequenceandtissuedistributionpredictingunappreciatedfunctionaldiversity.Toexaminefunctionaldifferences,wecom...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期CystamineandcysteamineincreasebrainlevelsofBDNFinHuntingtondiseaseviaHSJ1bandtransglutaminase
...riAnatomiaPatològica,FacultatdeMedicina,Institutd’InvestigacionsBiomèdiques,UniversitatdeBarcelona,Barcelona,Spain.3INSERM,AvenirGroup,LaboratoryofGenomicBiology,CentrePaulBroca,Paris,France.4URACEA/CNRS2210,ServiceHospitalierFrédéricJoliotandImaGeneprogram,DépartementdeRecherchesMédicales,D...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期ComplementreceptorsregulatedifferentiationofbonemarrowplasmacellprecursorsexpressingtranscriptionfactorsBlimp-1andXBP-1
...emory,weanalyzedtheresponseagainstviralparticlesderivedfromthebacteriophageQinmicedeficientinCD21–CD35(Cr2–/–).Despitehighlyefficientinductionofearlyantibodyresponsesandgerminalcenter(GC)reactionstoimmunizationwithQ,Cr2–/–miceexhibitedimpairedantibodypersistenceparalleledbyastronglyreduced...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期ProteinCLevelsAreRegulatedbyaQuantitativeTraitLocusonChromosome16
...eticmap.Variancecomponentlinkagemethodswereusedtoevaluatelinkageandtodetectquantitativetraitloci(QTL).Aregiononchromosome16(16q23),flankedbymarkersD16S3106andD16S516,showedstrongevidenceoflinkagewithPClevels(LOD=3.69).Thisregioncontains1positionalcandidategene,theNAD(P)H:dehydrogenasequinone1(NQO1),...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第7期大陆地区引用次数最高的生物类论文
...引次数最多的20篇文章:TheERA-40re-analysis(Cited624time(s))2005;QuarterlyJournaloftheRoyalMeteorologicalSociety;Uppala,S.M.,Karing;llberg,P.W.,Simmons,A.J.,Andrae,U.,daCostaBechtold,V.,...Effectsofradiotherapyandofdifferencesintheextentofsurgeryforearlybreastcanceronlocalrecurrenceand15-ye...
医学教育;科教新闻DetectionandIdentificationofEhrlichiaspp.inTicksCollectedinTunisiaandMorocco
...teur,Paris,FranceABSTRACTAbroad-range16SrRNAgenePCRassayfollowedbypartialsequencingofthe16SrRNAgenewasusedforthedetectionofmembersofthefamilyAnaplasmataceaeinticksinNorthAfrica.Atotalof418questingIxodesricinustickscollectedinTunisiaandMorocco,aswellas188Rhipicephalusticksfromdogsand52Hyalommaticksfr...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期肌醇六磷酸对结肠癌HT29细胞分化的影响
...HUMANCOLONCARCINOMA LIUXIAOYAN,SONGYANG DepartmentofNutrition,QingdaoUniversityMedicalCollege,Qingdao266021,China [ABSTRACT]ObjectiveTostudytheeffectofinositolhexaphosphate(IP6)onHT29celldifferentiationandexploreitsmechanisms.MethodsHT29cellswereculturedwithdifferentconce...
医源资料库;在线期刊;齐鲁医学杂志;2008年第23卷第3期HIV-1ProteaseandReverse-TranscriptaseMutations:CorrelationswithAntiretroviralTherapyinSubtypeBIsolatesandImplicationsforDrug-ResistanceSurvei
...mparedtheprevalenceofproteaseandreverse-transcriptase(RT)mutationsinHIV-1sequencesfrompersonswithandwithoutprevioustreatmentwithproteaseinhibitors(PIs),nucleosideRTinhibitors(NRTIs),andnonnucleosideRTinhibitors(NNRTIs).Treatment-associatedmutationsinproteaseisolatesfrom5867personsandRTisolatesfrom62...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第15期