EssentialRoleforClassIIPhosphoinositide3-kinase-IsoforminCa2+-Induced,Rho-andRhoKinase-DependentRegulationofMyosinPhosphataseandContraction
...e-silencingtechnique,allowedustodeterminetheroleofphosphoinositide3-kinase(PI3K)classII-isoform(PI3K-C2)asanovel,Ca2+-dependentregulatorofmyosinlight-chainphosphatase(MLCP)andcontraction.TheCa2+-ionophoreionomycininducedarobustcontractileresponsewithanincreaseintheintracellularfreeCa2+concentration(...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期溃疡贴用于骨科Ⅰ度、Ⅱ度褥疮治疗中的临床观察
...口的大小选择适当尺寸的溃疡贴敷于伤口处。密切观察,渗出物多时每日更换敷料;渗出物少的则根据具体情况3~4天更换1次;也可根据敷料表面药物消耗情况(敷料呈乳白色或透明色)决定更换时间。对照组:以红外线照射20m...
医源资料库;在线期刊;中华现代护理学杂志;2006年第3卷第6期流式细胞术定量检测细胞凋亡3种方法的比较研究
...,徐州221002关键词:凋亡;流式细胞术;AnnexinV TUNEL PI 摘 要 目的:探讨流式细胞术定量检测细胞凋亡3种方法的价值。方法:同时使用PI染色、TUNEL及AnnexinV/PI3种方法定量检测地塞米松处理小鼠的胸腺细胞凋亡发生率。...
合作平台;医学论文;临床医学与专科论文;检验医学Down-RegulationofUbiquitinLigaseCblInducedbyTwistHaploinsufficiencyinSaethre-ChotzenSyndromeResultsinIncreasedPIK/AktSignalingandOsteoblast
...tedwithdecreasedubiquitin-mediateddegradationofphosphatidylinositol3kinase(PI3K)andincreasedPI3KexpressionandPI3K/Aktsignaling.IncreasedPI3KimmunoreactivitywasalsofoundinosteoblastsinhistologicalsectionsofaffectedcranialsuturesfromSCSpatients.TransfectionwithTwistorCblabolishedtheincreasedPI3K/Aktsi...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期PI3Kintegratestheactionofinsulinandleptinonhypothalamicneurons
...shington,USA.AbstractCentralcontrolofenergybalancedependsontheabilityofproopiomelanocortin(POMC)oragouti-relatedprotein(Agrp)hypothalamicneuronstosenseandrespondtochangesinperipheralenergystores.Leptinandinsulinhavebeenimplicatedascirculatingindicatorsofadiposity,butitisnotclearhowchangesintheirleve...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期Anti-CD63antibodiessuppressIgE-dependentallergicreactionsinvitroandinvivo
...)inducessecretionofpreformedallergymediators(degranulation)andsynthesisoflipidmediatorsandcytokines.Degranulationproducesmanysymptomsofimmediate-typeallergicreactionsandismodulatedbyadhesiontosurfacescoatedwithspecificextracellularmatrix(ECM)proteins.Thesignalsinvolvedinthismodulationaremostlyunknow...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期IncreasedPI3-KinaseinPresympatheticBrainAreasoftheSpontaneouslyHypertensiveRat
...ctExistingevidenceledustohypothesizethatincreasesinp85,aregulatorysubunitofPI3-kinase,inpresympatheticbrainareascontributetohypertension.PI3-kinasep85,p110,andp110mRNAwas1.5-to2-foldhigherintheparaventricularnucleus(PVN)ofspontaneouslyhypertensiverats(SHR)comparedwiththeircontrols,WistarKyotorats(WK...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第2期两性离子流动相离子色谱法测定硼酸根
...测硼酸根,利用混合两性离子淋洗系统。该系统混合不同pI值的两性离子(pI值大于7的,称为碱性两性离子Zb;pI值小于7的,称之为酸性两性离子Za),混合后淋洗液的pH值介于pIb和pIa之间,形成了Zb-和ZHa+,具有一定的淋洗强度...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例RegulationofanaphylacticresponsesbyphosphatidylinositolphosphatekinasetypeI
...harmacology,StateUniversityofNewYork,StonyBrook,NY11794Themembranephospholipidphosphatidylinositol4,5-bisphosphate[PI(4,5)P2]isacriticalsignaltransducerineukaryoticcells.However,thephysiologicalrolesofthetypeIphosphatidylinositolphosphatekinases(PIPKIs)thatsynthesizePI(4,5)P2arelargelyunknown.Here,w...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期InsulinSignalinginArteriesPreventsSmoothMuscleApoptosis
...lcells,11andmonocytes.12Thiseffectismediatedbyphosphatidylinositol3-kinase(PI3K)andthedownstreamsignalAkt/proteinkinaseB(PKB)butdoesnotrequireactivationofmitogen-activatedproteinkinases.13VSMCapoptosisoccursinatheroscleroticlesionsinhumans,rabbits,andpigs,andinthethickenedintimaformedafterpercutaneo...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第4期