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TrappingofaNonpeptideLigandbytheExtracellularDomainsoftheGonadotropin-ReleasingHormoneReceptorResultsinInsurmountableAntagonism
...sTAK-013toaninsurmountableantagonist.Inaddition,mutationofMet-24toLeuintheaminoterminusofhGnRHRalsoablatestheinsurmountableantagonismofTAK-013.ThemechanismofinsurmountabilityofTAK-013wasdeterminedtobegovernedbyitsrateofdissociationfromthereceptor.AlthoughtheassociationratesofTAK-013tohGnRHR,mGnRHR,a...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第8期 -
RecombinantEnzymesOverexpressedinBacteriaShowBroadCatalyticSpecificityofHumanCytochromeP4502W1andLimitedActivityofHumanCytochromeP4502S1
...ativereportshaveappearedintheliterature.CytochromeP4502W1catalyzedbenzphetamineN-demethylation(kcat,3.8/min)andarachidonicacidoxidation,albeitataverylowrate(0.05/min).Inaumugenotoxicityscreen,cytochromeP4502W1catalyzedtheactivationofseveralprocarcinogens,particularlypolycyclichydrocarbondiols,butcyt...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第6期 -
戊型肝炎病毒线性抗原表位克隆及表达的初步研究
...imerswasconnectedtoneighboringgenebyaDNAlinkerencodingGly-Arg-ProattheN-terminalandPro-Arg-GlyattheC-terminalforthecleavageofmultimersbyclostripain.Results ThemultimerwereclonedintotheexpressionvectorpQE30andexpressedinE.coliM15withisopropylβ-D-thiogalatopyranosideinduction.Theexpressionmultimeri...
合作平台；医学论文；临床医学与专科论文；检验医学 -
隐匿型阴茎的手术治疗（附35例报告）
...nofpeniletunicaeandthefixationatthebaseofthepenis.Furtherstudyneededtodeterminethenaturalhistoryofthesedisordersaswellaswhichconditionsandwhatagewillbenefitmostfromsurgicalintervention. Keywordsconcealedpenissurgicalinterventionrestorationfixation 隐匿型阴茎或曰“潜伏阴茎”，...
合作平台；在线期刊；中华现代临床医学杂志；2005年第3卷第4期 -
Ⅰ、Ⅱ型精神分裂症事件相关电位对比及相关性研究
【摘要】目的：探讨Ⅰ、Ⅱ型精神分裂症患者事件相关电位P300的特点及事件相关电位与阴性、阳性症状的相关性。方法：对46例精神分裂症患者及32名健康志愿者进行事件相关电位P300的检测，并把患者组按PANSS的评分结果分为Ⅰ...
医源资料库；在线期刊；中国民康医学；2007年第19卷第5期 -
甲磺酸罗哌卡因与盐酸布比卡因低位硬膜外阻滞的效应比较
...forlowerepiduralblock.Thesensoryblock,motorblock,qualityofanalgesiaandabdominalwallrelaxationandtheintervalofP-RandQRSwereassessed.ResultsThepercentageofsensoryblocktoT6levelandBromage≥2scaleswere83.3%,86.7%,76.7%and90%inexperimentandcontrolgroupsrespectively.ThetimeofBromagetomaximalscalewaslong...
医源资料库；在线期刊；中华医药杂志；2009年第9卷第1期 -
TheBreastCancerResistanceProtein(BCRP/ABCG2)AffectsPharmacokinetics,HepatobiliaryExcretion,andMilkSecretionoftheAntibioticNitrofurantoin
...nitrofurantoinisefficientlytransportedbymurineBcrp1andhumanBCRP.Afteroraladministrationof10mg/kgnitrofurantoin,theareaundertheplasmaconcentrationtimecurveinBcrp1knockoutmicewasalmost4-foldhigherthaninwild-typemice(148.8±30.4versus37.5±6.8min·e/ml);andafteri.v.administration(5mg/kg),2-foldhigher(1...
医源资料库；在线期刊；分子药理学杂志；2005年第67卷第5期 -
Ⅰ类与Ⅱ类矢状骨面型替牙期儿童上气道宽度和舌骨位置差异的研究
...之相连的舌体后移造成口咽部舌根后气道狭窄,表现为生命间隙PAS和软腭尖后气道间隙UMPW的减小。OSAS作为潜在的致死性疾病，由于其高危害性正日益受到重视，如今已发展为一个多学科合作研究的重要课题。该病多发生于成年...
医源资料库；在线期刊；齐鲁医学杂志；2009年第24卷第4期 -
RapidandRobustProtectionagainstCocaine-InducedLethalityinRatsbytheBacterialCocaineEsterase
...tsofCocE(S117AorY44F)failedtoprotectratsfromthetoxiceffectsofcocaine,confirmingtheprotectiveeffectsareduetohydrolyticactivity.However,butyrylcholinesterase,anendogenouscocaine-hydrolyzingenzyme,wasinactive(1.3-13mg,i.v.)inthisrattoxicityprocedure.Furthermore,CocEdidnotblockthelethalityofWIN-35065-2(...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第12期 -
AssociationofTumorNecrosisFactora-2anda-8MicrosatelliteAlleleswithHumanPapillomavirusandSquamousIntraepithelialLesionsamongWomeninBrazil
...5to75(median=45)years.ThesepatientswerefollowedupforroutinegynecologicalexaminationattheDivisionofInfectiousDiseasesinGynecologyandObstetricsoftheUniversityHospital,SchoolofMedicine,UniversityofSoPaulo(HC-FMRPUSP),RibeiroPreto,SoPaulo,Brazil,fromFebruary1999toOctober2000.Samplecollection.Allwomensub...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第8期