Glucose-evokedalterationsinconnexin43-mediatedcell-to-cellcommunicationinhumancollectingduct:apossibleroleindiabeticnephropathy
...haveutilizedamodelhumancollectingductcellline(HCD)toassesstheroleofconnexin43(Cx43)-mediatedgapjunctionsinthetransferofintracellularCa2+transientswithincoupledcellclusters.HCDcellsexpressCx43mRNAandprotein,aswellasthatforthemechanosensitivetransientreceptorpotentialreceptor(TRPV4).Mechanicalstimulat...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第11期Cx32、Cx43在慢性浅表性胃炎、癌前病变及胃癌中的表达变化
【摘要】目的观察Cx32、Cx43在慢性浅表性胃炎(CSG)和癌前病变(PL)和胃癌(GC)中的表达情况。方法采用免疫组织化学SABC法检测Cx32、Cx43在33例慢性浅表性胃炎、88例癌前病变及70例胃癌患者胃黏膜中表达规律。结果Cx32、Cx43阳性表达...
医源资料库;在线期刊;中华现代内科学杂志;2008年第5卷第3期HeterocellularContactattheMyoendothelialJunctionInfluencesGapJunctionOrganization
...esofmurineECandVSMC.ImmunoctytochemistryandimmunoblotsdemonstratedCx37andCx43inbothcelltypes,whereasCx40wasfoundonlyinEC.Cx37wasexcludedfromtheMEJinbothECandVSMC.ConnexincompositionaswellasfunctionalityofthegapjunctionsattheMEJwasassessedbymeasuringdiffusionaltransferofbiocytinandCy3.Usingconnexin-s...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第7期AntigenicCross-ReactivitybetweenSevereAcuteRespiratorySyndromeAssociatedCoronavirusandHumanCoronaviruses229EandOC43
...respiratorysyndrome(SARS)associatedcoronavirus(SARS-CoV)and2HCoVs(229EandOC43)wasdemonstratedinimmunizedanimalsandhumanserum.In5of11and10of11patientswithSARS,pairedserumsamplesshoweda4-foldincreaseinantibodytitersagainstHCoV-229EandHCoV-OC43,respectively,byIFA.Overall,serumsamplesfromconvalescentpat...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第12期Connexin43-dependentmechanismmodulatesreninsecretionandhypertension
...va,SchoolofMedicine,Geneva,Switzerland.AbstractToinvestigatethefunctionofCx43duringhypertension,westudiedthemouselineCx43KI32(KI32),inwhichthecodingregionofCx32replacesthatofCx43.WithinthekidneysofhomozygousKI32mice,Cx32wasexpressedincorticalandmedullarytubules,aswellasinsomeextra-andintraglomerular...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期肌苷对大鼠脑缺血再灌注后GAP43mRNA表达影响
...脑缺血再灌注后各时间点脑组织生长相关蛋白基因(GAP43mRNA)的表达。结果对照组于再灌注2h~7d、治疗组于再灌注12h~7d,GAP43mRNA表达与假手术组比较明显增多(t=2.70~29.84,P0.05),治疗组与对照组比较GAP43mRNA表达于再灌注2h...
医源资料库;在线期刊;齐鲁医学杂志;2006年第21卷第1期ImprovementoftheSpecificityofanEnzyme-LinkedImmunosorbentAssayforDiagnosisofParacoccidioidomycosis
...withPCMweretestedusingvariousapproaches,suchassodiummetaperiodateantigen(gp43)treatment,aserumabsorptionprocesswithCandidaalbicansorHistoplasmacapsulatumantigens,anddilutionofserumingalactose,themaincommonepitopeamongpathogenicfungi.ThemaximumspecificityfoundinthisELISAwas84%.Alloftheseprocedurespro...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期DiagnosisofNeuroparacoccidioidomycosisbyDetectionofCirculatingAntigenandAntibodyinCerebrospinalFluid
...roPCMwereanalyzedbyinh-ELISAfordetectionofcirculatingglycoproteinantigensof43kDa(gp43)and70kDa(gp70).Circulatinggp43andgp70antigensweredetectedinallCSFsamplesfrompatientswithneuroPCMatmeanconcentrationsof19.3and6.8μg/ml,respectively.Inaddition,bothgp43andgp70antigensweredetectedin10of11serumsamples...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期TDP-43蛋白积聚的机制
...化与细胞所胡红雨课题组的研究论文。该论文阐明了TDP-43蛋白的降解片段TDP-35是其在细胞质内形成包涵体的主要原因,并且包涵体的形成引起该蛋白质参与RNA加工功能的改变。肌萎缩侧索硬化症(AmyotrophicLateralSclerosis,ALS)和额颞叶...
行业资讯;临床快报;细胞分子与蛋白质组OxidizedPhospholipidsAlterVascularConnexinExpression,Phosphorylation,andHeterocellularCommunication
...rcellcocultures.OxPAPCappliedtocarotidsinducedanupregulationofbothCx37andCx43intheVSMC.InEC,Cx43wasupregulatedandCx37wasdownregulated,whereasCx40inECremainedconstant.Inthevascularcellcoculture,OxPAPCcausedsimilarchangesinCx37andCx43butcausedadecreaseinCx40inECandanelevationofCx40inVSMC.Inthecocultur...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第10期