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VegetarianismandvitaminB-12(cobalamin)deficiency
...2),whosesustainedinvestigationsofclinicallyrelevantissuesrelatedtovitaminB-12,folate,andone-carbonmetabolismearnedhimrespect,admiration,andstatusasoneofthegiantsinthisfield.(Internet:http://www.victorherbert.com,accessed4March2003.)3SupportedbyNIHgrantsR01CA58919andR01HD39295andbyaVeteransAffairsMer...
医源资料库；在线期刊；美国临床营养学杂志；2003年78卷第1期 -
TheEffectsofLeukocyte-Type12/15-LipoxygenaseonId3-MediatedVascularSmoothMuscleCellGrowth
...801394,Charlottesville,VA22908.E-mailcam8c@virginia.eduAbstractObjective—12/15-Lipoxygenase(12/15-LO)hasbeenimplicatedinthepathogenesisofvasculardisease.Vascularsmoothmusclecell(VSMC)proliferationisakeycomponentoftheresponsetoinjuryinvasculardisease.Theroleof12/15-LOinregulatingVSMCproliferationis...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第10期 -
ProportionofindividualswithlowserumvitaminB-12concentrationswithoutmacrocytosisishigherinthepost–folicacidfortificationperiodthanin
...m.ABSTRACTBackground:LargeintakesoffolicacidmaydelaythediagnosisofvitaminB-12deficiency,whichcouldleadtoirreversibleneuropathy.Objective:TheobjectiveofthisstudywastodeterminewhethertheproportionofindividualswithlowserumvitaminB-12withoutmacrocytosis(undiagnosedvitaminB-12deficiency)hasincreasedinthe...
医源资料库；在线期刊；美国临床营养学杂志；2007年86卷第4期 -
HSPA12BIsPredominantlyExpressedinEndothelialCellsandRequiredforAngiogenesis
【摘要】Objective-HSPA12BisthenewestmemberofHSP70familyofproteinsandisenrichedinatheroscleroticlesions.ThisstudyfocusedonHSPA12Bexpressioninmiceanditsinvolvementinangiogenesis.MethodsandResults-TheexpressionofHSPA12Binmiceandculturedcellswasstudiedby:(1)Northernblot;(2)insituhybridization;(3)imm...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第9期 -
AssessingtheassociationbetweenvitaminB-12statusandcognitivefunctioninolderadults
...406.Itiswellestablishedthattheclinicalmanifestationsofovert,severevitaminB-12deficiencyincludebothhematologic(macrocyticormegaloblasticanemia)andneurologic(subacutecombineddegenerationofthespinalcord,peripheralneuropathy,cognitiveimpairment)sequelae.Theneurologicconsequencesareofparticularconcern,be...
医源资料库；在线期刊；美国临床营养学杂志；2006年84卷第6期 -
白细胞介素12及其抗肿瘤作用
IL-12是新近发现的一种细胞因子，具有多种生物学活性，尤其是在抗肿瘤免疫和抗病毒免疫中有重要的作用。 一、IL-12概况 IL-12主要来源于单核/巨噬细胞、抗原递呈细胞和B细胞，是由相对分子质量为40×103和35×103两个亚...
合作平台；医学论文；外科论文；普通外科学 -
EffectoforalvitaminB-12withorwithoutfolicacidoncognitivefunctioninolderpeoplewithmildvitaminB-12deficiency:arandomized,placebo-controll
...tQLK3-CT-2002-01775fromtheFoundationtoPromoteResearchIntoFunctionalVitaminB12DeficiencyandtheEuropeanUnionBIOMEDDemonstrationProject;andgrant2004-E2fromtheNutriciaHealthFoundation,Wageningen,Netherlands.3AddressreprintrequeststoLCdeGroot,DivisionofHumanNutrition,WageningenUniversity,POBox8129,6700EV...
医源资料库；在线期刊；美国临床营养学杂志；2006年84卷第2期 -
TransgenicOverexpressionofADAMSuppressesMuscleRegenerationandAggravatesDystrophyinAgedmdxMice
...rationandgradualreplacementoftheskeletalmusclebyfatandconnectivetissue.ADAM12haspreviouslybeenshowntoalleviatethepathologyofyoungdystrophin-deficientmdxmice,amodelforDuchennemusculardystrophy.TheobservedeffectofADAM12wassuggestedtobemediatedviaamembrane-stabilizingup-regulationofutrophin,7Bintegrin,...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第11期 -
MMP-12与动脉粥样硬化
...Collagenases(MMP-1,-8,-13)Gelatinases(MMP-2,-9)Stromelysins(MMP-3,-10,-11,-12)Membrane-typeMMPs(MMP-14~17and-24~25)Others:matrilysin(MMP-7,-19-24,-26)TheFunctionsofMMPsPhysiological:EmbryonicdevelopmentOrganmorphogenesisNervegrowthBoneremodelingWoundhealingOvulationAngiogenesisPathological:Emphysema...
医源资料库；医学文档库；心血管相关 -
2009国家自然科学基金项目（生物类）
...学170人类NADPHsensor蛋白HSCARG调控机制研究郑晓峰30930020/C05012010-01至2013-12北京大学180结构修饰的siRNA合成和RNA干扰技术在药物靶标寻找中的研究张礼和20932001/B0207022010-01至2013-12北京大学180p53和PTEN之间的分子联系研究尹玉新30930021/C05...
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