IQGAP1MediatesVE-Cadherin-BasedCell-CellContactsandVEGFSignalingatAdherenceJunctionsLinkedtoAngiogenesis
【摘要】Objective-Vascularendothelialgrowthfactor(VEGF)inducesangiogenesisbystimulatingreactiveoxygenspecies(ROS)productionprimarilythroughtheVEGFreceptor-2(VEGFR2).Oneoftheinitialresponsesinestablishedvesselstostimulateangiogenesisislossofvascularendothelial(VE)-cadherin-basedcell-celladhesions...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第9期当归补血汤现代研究
...其中当归的化学成分主要包括:挥发油以蒿本内酯(ligustilide)的含量最高,还含有正丁烯内酯(n-butylidenephthalide)、归酮、月桂烯、α-蒎烯、β-蒎烯、β-水芹烯、莰烯、对聚伞素、壬二酸、葵二酸、大茴香酸、肉豆蔻酸、荆芥...
医源资料库;在线期刊;中华现代中医学杂志;2006年第2卷第6期MesangialcellNADPHoxidaseupregulationinhighglucoseisproteinkinaseCdependentandrequiredforcollagenIVexpression
...,CanadaABSTRACTExcesscollagenIVexpressionbymesangialcellscontributestodiabeticglomerulosclerosis.Wehypothesizedthatinhighglucosereactiveoxygenspecies(ROS)generationbyNADPHoxidaseisPKCdependentandrequiredforcollagenIVexpressionbymesangialcells.Inratmesangialcellsculturedin5mM(NG)or25mMD-glucose(HG),R...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第3期Grb2IsRequiredforAtheroscleroticLesionFormation
【摘要】Objective—Grb2isaubiquitouslyexpressedlinkerproteinthatcouplesgrowthfactorreceptoractivationtodownstreammitogen-activatedproteinkinase(MAPK)cascades.MacrophageproliferationanduptakeofmodifiedlipoproteinsarecriticalcomponentsofatherogenesiswhichrequireMAPKactivation.However,thepreci...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第6期Caspases:pharmacologicalmanipulationofcelldeath
DivisionofImmunogenetics,TumorImmunologyProgram,GermanCancerResearchCenter,Heidelberg,Germany.AbstractCaspases,afamilyofcysteineproteases,playacentralroleinapoptosis.Duringthelastdecade,majorprogresshasbeenmadetofurtherunderstandcaspasestructureandfunction,providingauniquebasisfordrugdesign.ThisRevi...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期Twosplicevariantsofclaudin-10inthekidneycreateparacellularporeswithdifferentionselectivities
【摘要】Membersofthelargeclaudinfamilyoftightjunction(TJ)proteinscreatethedifferencesinparacellularconductanceandchargeselectivityobservedamongdifferentepithelia.Previousstudiesdemonstratedthationicchargeselectivityisinfluencedbyacidicorbasicaminoacidsonthefirstextracellulardomainofclaudins.Weno...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期ClinicalandMolecularAnalysisofExtended-Spectrum-Lactamase-ProducingEnterobacteriaintheCommunitySetting
...KlebsiellapneumoniaeisolateexpressingSHV-4/TEM-15)responsibleforurinarytractinfections(UTIs)werefoundamong1,584strainscollectedfromcommunitypatients.Theaimofthepresentstudywastoelucidatetherouteofemergenceofthesetypicallynosocomialorganismsinthecommunity.Thus,thefilesofthefivepatientswereanalyzedove...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第10期ActivationofNAD(P)HoxidasebyoutwardmovementsofH+ionsinrenalmedullarythickascendinglimbofHenle
...,VirginiaABSTRACTThepresentstudywasdesignedtotestthehypothesisthattheproductionofsuperoxide(O2・)byNAD(P)HoxidaseiscoupledtotubularmetabolicactivitythroughionicactivationmediatedbyH+movementacrosscellmembrane.Usingdualfluorescentmicroscopicimaginganalysis,intracellularO2・levelsandpH(pHi)inrenalme...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期AnalysisofPromoterRegionsRegulatingBasalandInterleukin-4-InducibleExpressionoftheHumanCB1ReceptorGeneinTLymphocytes
...majorityofeffectsofcannabinoidsaremediatedbythetworeceptorsCB1andCB2.Inadditiontoneuronalcells,CB1receptorsareexpressedinTlymphocytes,inwhichtheyareinvolvedincannabinoid-inducedThelpercellbiasing.AlthoughbasallyexpressedonlyweaklyinTcells,CB1receptorsareup-regulatedinthesecellsbystimulisuchascannabi...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期AdrenomedullinProtectsfromExperimentalArthritisbyDown-RegulatingInflammationandThResponseandInducingRegulatoryTCells
【摘要】Rheumatoidarthritisisachronicautoimmunediseaseofunknownetiologycharacterizedbychronicinflammationinthejointsandsubsequentdestructionofthecartilageandbone.Thepresentstudyproposesanewstrategyforthetreatmentofarthritis:theadministrationoftheimmunomodulatoryneuropeptideadrenomedullin.Treatme...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期