StimulationofreninreleasebyprostaglandinE2ismediatedbyEP2andEP4receptorsinmousekidneys
...terized.Therefore,weinvestigatedtheeffectsPGE2onreninsecretionrates(RSR)fromisolated,perfusedkidneysofEP1-/-,EP2-/-,EP3-/-,EP4-/-,andwild-typemice.PGE2concentrationdependentlystimulatedRSRfromkidneysofallfourknockoutstrainswithathresholdconcentrationof1nMinEP1-/-,EP2-/-,EP3-/-,andwild-typemice,where...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第9期PPAR-ligandamelioratesacuterenalfailurebyreducingcisplatin-inducedincreasedexpressionofrenalendonucleaseG
...atedthatcisplatin-inducedinhibitionofsubstrateoxidationcanbereversedbytheadministrationofperoxisomeproliferator-activatedreceptor-(PPAR-)ligands,resultinginameliorationofrenalfunction.Wethereforehypothesizethatbyimprovingfattyacidoxidationinvivomightprotectrenalfunctionbyreducingbothapoptosisandnecr...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第11期Tlxactsasaproangiogenicswitchbyregulatingextracellularassemblyoffibronectinmatricesinretinalastrocytes
...yforStemCellBiology,CenterforDevelopmentalBiology,InstituteofPhysicalandChemicalResearch(RIKEN),Kobe,Japan.2RegeneronPharmaceuticalsInc.,Tarrytown,NewYork,USA.3GeneExpressionLaboratory,TheSalkInstituteforBiologicalStudies,LaJolla,California,USA.AbstractInresponsetohypoxia,hypoxia-induciblefactorsact...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期ExpressionanddistributionofHuRduringATPdepletionandrecoveryinproximaltubulecells
【摘要】HumanantigenR(HuR)isanucleocytoplasmicshuttlingproteinthatbindstoandstabilizesmRNAscontainingadenine-anduridine-richelements.Undernormalgrowthconditions,thebulkofHuRismaintainedinthenucleus,butunderconditionsofcellstress,HuRmaybecomemoreprevalentinthecytosol,whereitcanstabilizemRNAandreg...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期ACriticalRoleforPeroxisomalProliferator-ActivatedReceptor-NuclearReceptorsintheDevelopmentofCardiomyocyteDegenerationandNecrosis
...yhomeostasis.PPAR-activators,includingfibrates,havebeenusedtotreatdyslipidemiaforseveraldecades.Incontrasttotheirknowneffectsonlipids,thepharmacologicalconsequencesofPPAR-activationoncardiacmetabolismandfunctionarenotwellunderstood.Therefore,weevaluatedtherolethatPPAR-receptorsplayintheheart.Ourstud...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期FarnesyltransferaseInhibitorBMS-214662InducesApoptosisinMyelomaCellsthroughPUMAUp-Regulation,BaxandBakActivation,andMcl-1Elimination
DepartamentodeBioquimicayBiologiaMolecularyCelular,FacultaddeCiencias,UniversidaddeZaragoza,Zaragoza,SpainAbstractWehavestudiedthemechanismofapoptosiselicitedbythefarnesyltransferaseinhibitor(R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzo...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期AcutedecreaseinrenalmicrovascularPO2duringacutenormovolemichemodilution
...excessoftheoxygendemandundernormalcircumstances.Inaratmodelofacutenormovolemichemodilution(ANH),westudiedtheeffectofreducedhematocritonrenalregionalandmicrovascularoxygenation.Experimentswereperformedin12anesthetizedmaleWistarrats.SixanimalsunderwentfourstepsofANH(hematocrit25,15,10,and10%).Sixanima...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期SuppressionandRegressionofChoroidalNeovascularizationbySystemicAdministrationofan51IntegrinAntagonist
...inchoroidalneovascularization.Implantationofanosmoticpumpdelivering1.5or10µg/h(1.8or12mg/kg/day)of3-(2-{1-alkyl-5-[(pyridin-2-ylamino)-methyl]-pyrrolidin-3-yloxy}-acetylamino)-2-(alkylamino)-propionicacid(JSM6427),aselective51antagonist,causedsignificantsuppressionofchoroidalneovascularization...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期Coexpressionof-OpioidReceptorswithµReceptorsinGH3CellsChangestheFunctionalResponsetoµAgonistsfromInhibitorytoExcitatory
...heactivationofexogenouslyexpressedopioidreceptors.InGH3cellsexpressingonlyµreceptors(GH3MORcells),theµreceptor-specificligand[D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin(DAMGO)inhibitedspontaneousCa2+signalingbytheinhibitionofvoltage-gatedCa2+channels,activationofinward-rectifyingK+channels,and...
医源资料库;在线期刊;分子药理学杂志;2003年第63卷第1期ChronicdDAVPinfusioninratsdecreasestheexpressionofP2Y2receptorininnermedullaandP2Y2receptor-mediatedPGE2releasebyIMCD
...usecirculatingvasopressin(AVP)levelsareincreasedindehydratedcondition,weexaminedwhetherchronicinfusionofdesmopressin(dDAVP)hasasimilareffectontheexpressionandactivityofP2Y2-R.GroupsofratswereinfusedwithsalineordDAVP(5or20ng/hsc,5or6days)viaosmoticminipumpsandeuthanized.Urinevolume,osmolality,andPGE2...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第8期