GenisteinInducesPhenotypicReversionofEndoglinDeficiencyinHumanProstateCancerCells
...ty,anditsexpressionislostduringPCaprogression.Itisthereforeimportanttodeterminewhetherendoglinlossaffectsgenistein‘sefficacyand,ifso,bywhatmechanism.Inthecurrentstudy,genisteinwasshowntoinducereversionofendoglin-deficientcellstoalowmotility,endoglin-repletephenotype.BecauseendoglinsuppressesPCacel...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期ImpairmentofFunctionalCapillaryDensitybutNotOxygenDeliveryintheHamsterWindowChamberduringSevereExperimentalMalaria
【摘要】MicrocirculatorychangesandtissueoxygenationwereinvestigatedduringPlasmodiumberghei-inducedseveremalariainthehamsterwindowchambermodel,whichallowschronic,noninvasiveinvestigationofthemicrovasculatureinanawakeanimal.Themainfindingwasthatfunctionalcapillarydensity,aparameterreflectingtissue...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期Vegetable-bornelutein,lycopene,andß-carotenecompeteforincorporationintochylomicrons,withnoadverseeffectonthemedium-term(3-wk)plasmasta
...aneTyssandier,NicolasCardinault,CatherineCaris-Veyrat,Marie-JosèpheAmiot,PascalGrolier,CorinneBouteloup,VéroniqueAzais-BraescoandPatrickBorel1FromtheUnitéMaladiesMétaboliquesetMicronutriments,INRA,Clermont-Ferrand/Theix,Saint-Genès-Champanelle,France(VT,NC,PG,VA-B,...
医源资料库;在线期刊;美国临床营养学杂志;2002年75卷第3期ArgininevasopressinstimulatesH+-ATPaseinMDCKcellsviaV1(cellCa2+)andV2(cAMP)receptors
...fluorescentprobesBCECF-AMandfluo-4-AM,respectively.ThepHirecoveryratewasexaminedafterintracellularacidificationfollowinganNH4Clpulse,inthepresenceofzeroNa+plusSchering28080(aspecificinhibitorofH+-K+-ATPase).AVP(10-12-10-6M)increasedtherateofpHirecoveryand[Ca2+]iinadose-dependentmanner.V1-orV2-recept...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第2期SerotoninIncreasesSusceptibilitytoPulmonaryHypertensioninBMPR2-DeficientMice
...phogeneticproteintypeII(BMPR-II)receptorunderliethemajority(70%)ofcasesoffamilialpulmonaryarterialhypertension(FPAH),anddysfunctionofBMPsignalinghasbeenimplicatedinotherformsofPAH.ThereduceddiseasegenepenetranceinFPAHindicatesthatothergeneticand/orenvironmentalfactorsmayalsoberequiredfortheclinicalm...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第3期InhibitionofSmoothMuscleProliferationbyUrea-BasedAlkanoicAcidsviaPeroxisomeProliferator-ActivatedReceptor-DependentRepressionofCyclinD
...idehydrolaseinhibitorwasshowntoattenuatesmoothmusclecellproliferation.Weexaminedthepossibilitythaturea-basedalkanoicacidsactivatethenuclearreceptorperoxisomeproliferator-activatedreceptor(PPAR)andtheroleofPPARinsmoothmusclecellproliferation.MethodsandResults-AlkanoicacidstransactivatedPPAR,inducedbi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第11期更年期综合征中医药研究概况
...更年期综合征临床研究表明可使阴道脱落细胞成熟指数(MI)升高(P<0.01)[30]。此外,有研究表明,中药治疗更年期综合征过程中对血管收缩因子[31]、对卵巢子宫阴道等组织中受体[32]、对卵巢基因及生物活性因子[...
医源资料库;在线期刊;中华中西医杂志;2008年第9卷第1期Dietarycarotenoidsandriskofcoronaryarterydiseaseinwomen
...tion,HarvardSchoolofPublicHealth,Boston(MJS,ER,andWCW);theDepartmentofEpidemiology,HarvardSchoolofPublicHealth,Boston(MJS,ER,DS,JEM,andWCW);theChanningLaboratory,DepartmentofMedicine,BrighamandWomensHospitalandHarvardMedicalSchool,Boston(MJS,ER,DS,JEM,andWCW);theDepartmentofBiostatistics,Harva...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第6期Mousemodelofinduciblenephrogenicdiabetesinsipidusproducedbyfloxedaquaporin-2genedeletion
...re,wereportaninduciblemousemodelofAQP2genedeletionwithseverepolyuriainadultmice.LoxPsequenceswereinsertedintointrons1and2inthemouseAQP2genebyhomologousrecombinationinembryonicstemcells.Matingofgerm-lineAQP2-loxPmicewithtamoxifen-inducibleCre-expressingmiceproducedoffspringwithinduciblehomozygousCre-...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期ActivationoftheDual-Leucine-Zipper-BearingKinaseandInductionofβ-CellApoptosisbytheImmunosuppressiveDrugCyclosporinA
...ulatedtheenzymaticactivityofcellularDLKinaninvitrokinaseassay.ImmunocytochemistryrevealedthattheoverexpressionofDLKbutnotitskinase-deadmutantinducedapoptosisandenhancedcyclosporinA-inducedapoptosistoahigherextentthanthedrugalone.Moreover,inthepresenceofDLK,theeffectiveconcentrationforcyclosporinA-ca...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期