OverexpressionoftheCytotoxicTCell(CT)CarbohydrateInhibitsMuscularDystrophyinthedyWMouseModelofCongenitalMuscularDystrophyA
...nemusculardystrophy,butnonehavebeenshownalsotobeeffectiveinmousemodelsforlaminin2-deficientcongenitalmusculardystrophy(MDC1A).Here,weshowthatoverexpressionofthecytotoxicTcell(CT)GalNActransferase(Galgt2)iseffectiveininhibitingthedevelopmentofmusclepathologyinthedyWmousemodelofMDC1A,muchaswehadprevio...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期OdontogenicKeratocystsArisefromQuiescentEpithelialRestsandAreAssociatedwithDeregulatedHedgehogSignalinginMiceandHumans
...effectorGli2issufficientforhighlypenetrantkeratocystdevelopmentintransgenicmice.Mouseandhumankeratocystsexpressedsimilarmarkers,leadingtotoothmisalignment,boneremodeling,andcraniofacialabnormalities.WedetectedHhtargetgeneexpressioninepithelialcellsliningkeratocystsfrombothspecies,implicatingderegula...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期Identificationof43StreptococcusSpeciesbyPyrosequencingAnalysisofthernpBGene
DepartmentofClinicalMicrobiology,UppsalaUniversityHospital,SE-75185Uppsala,SwedenBiotageAB,Kungsgatan76,SE-75318Uppsala,SwedenABSTRACTPyrosequencingtechnologywasevaluatedforidentificationofspecieswithintheStreptococcusgenus.TwovariableregionsinthernpBgene,whichencodestheRNAsubunitofendonucleaseP,wer...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期IncreasedCholesterolDeposition,ExpressionofScavengerReceptors,andResponsetoChemotacticFactorsinAbca1-DeficientMacrophages
...nemarrowtransplantedfromATP-bindingcassettetransporterA1(ABCA1)–deficientmiceintonormalmiceprovidesdirectevidencethattheabsenceofleukocyteABCA1exertsamarkedproatherogeniceffectindependentofchangesinplasmalipids,suggestingthatABCA1playsakeyroleintheregulationofcholesterolhomeostasisandfunctionofmac...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第6期TheRoleofNicotinamideAdenineDinucleotidePhosphateOxidase-DerivedReactiveOxygenSpeciesintheAcquisitionofMetastaticAbilityofTumorCells
【摘要】Weexaminedtheroleofphagocyte-derivedoxygenradicalsintumorcellacquisitionofmetastaticphenotypebycomparinggp91phoxC/CmiceandC57BL/6Jwild-type(WT)mice.Thegp91phoxC/Cmouseisdeficientinthegp91phoxgene,anessentialsubunitofthephagocytenicotinamideadeninedinucleotidephosphateoxidasethatgenerates...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期DecreasedMacrophageNumberandActivationLeadtoReducedLymphaticVesselFormationandContributetoImpairedDiabeticWoundHealing
...hepresenceofactivatedmacrophagesandtheformationoflymphaticvesselsarerate-limitingtothehealingofdiabeticwounds.Wehavepreviouslyshownthatmacrophagescontributetothelymphaticvesselsthatformduringtheacutephaseofcornealwoundhealing.Wenowdemonstratethatthisisageneralphenomenon;cellsthatco-stainforthemacrop...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期NegativeRegulationofVEGF-InducedVascularLeakagebyBlockadeofAngiotensinIIType1Receptor
...ndResults-WeshowedthatVEGF-mediatedvascularhyperpermeabilitywassuppressedinmicegivenAIItype1receptor(AT1R)blocker(ARB);theeffectwasalsoseeninAT1R-deficientmice.Inthissystem,wefoundthatARBinhibitedVEGF-inducedgapformation.Furthermore,weascertainedthatangioedemainducedbyoverexpressionofVEGFdecreasedno...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期Dietarysupplementationwitheicosapentaenoicacid,butnotwithotherlong-chainn-3orn-6polyunsaturatedfattyacids,decreasesnaturalkillercellactivi
...well,ParveenYaqoob,EricANewsholmeandPhilipCCalder1FromtheDepartmentofBiochemistry,UniversityofOxford,Oxford,UnitedKingdom;UnileverResearchColworthLaboratory,Sharnbrook,UnitedKingdom;TheHughSinclairUnitofHumanNutrition,DepartmentofFoodScienceandTechnology,UniversityofReading,Reading,UnitedKingdom;and...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第3期LossoftheLysophosphatidylcholineEffector,G2A,AmelioratesAorticAtherosclerosisinLow-DensityLipoproteinReceptorKnockoutMice
...thisreceptorinvivo.WeinvestigatedtheabilityofG2Atomodulateatherosclerosisinmice.MethodsandResults-WemeasuredatherosclerosisinG2A+/+andG2A-/-LDLreceptorknockout(LDLR-/-)mice.Consistentwithapreviousstudy,earlylesionsizeattheaorticsinuswasunaffectedbyG2Adeficiency.However,G2Adeficiencyattenuatedlesionp...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期Cysteine2.59(89)intheSecondTransmembraneDomainofHumanCB2ReceptorIsAccessiblewithintheLigandBindingCrevice:EvidenceforPossibleCB2Deviatio
...LouisvilleSchoolofMedicine,Louisville,Kentucky(R.Z.,Z.-H.S.)DepartmentofChemistryandBiochemistry,UniversityofNorthCarolinaGreensboro,Greensboro,NorthCarolina(D.P.H.,J.B.-N.,P.H.R.)AbstractInthisstudy,thesensitivityoftheCB2receptortomethanethiosulfonate(MTS)derivativeswastested,andanativecysteineresi...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第1期