Toll-LikeReceptors2-DeficientMiceAreProtectedAgainstPostischemicCoronaryEndothelialDysfunction
...n.Becauseleukocyteadhesionisacriticaleventinendothelialinjuryinducedbyischemia/reperfusion(I/R),weassessedwhetherTLR2wereinvolvedinI/R-inducedcoronaryendothelialinjury.MethodsandResults-Ischemia-reperfusionmarkedlydecreasedNO-mediatedcoronaryrelaxationstoacetylcholineassessedexvivo.Incontrast,inTLR2...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期LithiumtreatmentinhibitsrenalGSK-3activityandpromotescyclooxygenase2-dependentpolyuria
...terforHealthServiceResearch,VanderbiltUniversityMedicalCenter,andVeteransAdministrationMedicalCenter,Nashville,TennesseeABSTRACTTheuseofLiClinclinicalpsychiatryisroutinelycomplicatedbyovertnephrogenicdiabetesinsipidus(NDI),themechanismofwhichisincompletelyunderstood.Invitrostudiesindicatethatlithium...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期SleepandSleep-disorderedBreathinginAdultswithPredominantlyMildObstructiveAirwayDisease
...n‘sHospital,CaseWesternReserveUniversity,Cleveland,Ohio;DepartmentofEpidemiologyandBiostatistics,andDepartmentofMedicinePulmonarySection,UniversityofArizona,Tucson,Arizona;DivisionofEpidemiology,SchoolofPublicHealth,UniversityofMinnesota,Minneapolis,Minnesota;DepartmentofEpidemiology,TheJohnsHopki...
医源资料库;在线期刊;美国呼吸和危急护理医学;2003年第167卷第1期CXCR2BlockadeImpairsAngiotensinII–InducedCCChemokineSynthesisandMononuclearLeukocyteInfiltration
...ucedCXCandCCchemokines,followedbyneutrophilandmononuclearcellrecruitment.AdministrationoftheCXCR2antagonist,SB-517785-M,inhibitedtheinfiltrationofbothneutrophils(98%)andmononuclearcells(60%).SB-517785-MhadnoeffectontheincreaseinCXCchemokinelevelsbutreducedMCP-1,RANTES,andMIP-1releaseby66%,63%,and80%...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第11期CorticosteroidsInhibitCellDeathInducedbyDoxorubicininCardiomyocytes:InductionofAntiapoptosis,Antioxidant,andDetoxificationGenes
...stdosetested,0.1e(or3.5e蘥/dl),inhibitedapoptosisbyapproximately25%asdeterminedbycaspaseactivity.With1eCT,cardiomyocytesgainacytoprotectiveeffectafter8hofincubationandremainprotectedforatleast72h.Hydrocortisone,cortisone,dexamethasone,andaldosteronebutnotandrostenedioneorcholesterolalsoinducedcytop...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期AtherosclerosisinMiceIsNotAffectedbyaReductioninTissueFactorExpression
【摘要】Objective-Todeterminewhethertissuefactor(TF)contributestotheprogressionofatheroscleroticlesionsinmice.MethodsandResults-Wedeterminedtheeffectofa50%reductionofTFlevelsinallcellsonatherosclerosisinapolipoproteinE-deficient(apoE-/-)mice.Nodifferenceswereobservedintheextentofatherosclerosisi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第3期EffectoforangejuiceintakeonvitaminCconcentrationsandbiomarkersofantioxidantstatusinhumans
...hnology,InstitutodelFrío-CSIC,Madrid(MPC,BdA,andLP);andtheUnitofVitamins,SectionofNutrition,ClínicaPuertadeHierro,Madrid(BOandFG).2AnearlierversionofthisarticlewaspresentedatPhytochemicalSocietyofEurope(PSE)SymposiumonDietaryPhytochemicalsandHumanHealth,Salamanca,Spain,April2002.3Suppo...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第3期Conjugatedlinoleicacidsupplementation,insulinsensitivity,andlipoproteinmetabolisminpatientswithtype2diabetesmellitus
...naMoloney,Toh-PengYeow,AnneMullen,JohnJNolanandHelenMRoche1FromtheNutrigenomicsResearchGroup,DepartmentofClinicalMedicine,TrinityCentreforHealthSciences,Dublin(FM,AM,andHMR),andtheMetabolicResearchUnit,StJamessHospital,Dublin(T-PYandJJN).2SupportedbytheWellcomeTrust,UnitedKingdom.3Addressrepri...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第4期VascularEndothelialGrowthFactorReceptor2PlaysaRoleintheActivationofAorticEndothelialCellsbyOxidizedPhospholipids
...rckinase.【关键词】oxidizedphospholipidsVEGFRatherosclerosisendotheliumIntroductionMonocyteadhesiontotheendotheliumandmigrationintothesubendothelialspaceareearlyeventsinthechronicinflammatoryprocessofatherosclerosis.1Oxidizedproductsof1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphorylcholine(O...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第2期ActivationofATP-BindingCassetteTransporterA1TranscriptionbyChromatinRemodelingComplex
...SW-13cells,butnotacatalyticallyinactivemutant,increasedABCA1mRNAlevelsdeterminedbyRT-PCR.TheseeffectswereenhancedbyLXRandRXRagonists.In293T(epithelialkidneycellline)andHep3B(hepatocytecellline)cells,smallinterferingRNAagainstBRG-1/brmalsoaffectedABCA1mRNAlevels.SynergisticactivationofABCA1wasobtaine...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第6期