NuclearLocalizationofNADPH:Cytochromec(P450)ReductaseEnhancestheCytotoxicityofMitomycinCtoChineseHamsterOvaryCells
...erCenter,YaleUniversitySchoolofMedicine,NewHaven,ConnecticutDepartmentofChemistry(M.T.),HunterCollege,CityUniversityofNewYork,NewYork,NewYorkAbstractOverexpressionofendoplasmicreticulum-localizedNADPH:cytochromec(P450)reductase(NPR)inChinesehamsterovarycellsincreasesthehypoxic/aerobicdifferentialtox...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第2期IntestinalNa-PicotransporteradaptationtodietaryPicontentinvitaminDreceptornullmice
【摘要】RecentstudiessuggestthatvitaminDmayplayaroleinintestinalNa+-dependentphosphatetransportadaptationtovariablelevelsofdietaryPi.Therefore,thegoalofthecurrentstudywastoassessNa+-dependentPicotransportactivityintransgenicmicetodeterminewhethervitaminDisanessentialmediatorofthisprocess.Intesti...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第7期Interactionbetweenthe90-kDaHeatShockProteinandSolubleGuanylylCyclase:PhysiologicalSignificanceandMappingoftheDomainsMediatingBinding
...eorgia,Augusta,Georgia(G.Y.,R.C.V.,J.D.C.)DepartmentofPharmacologyandPrograminVascularCellSignalingandTherapeutics,BoyerCenterforMolecularMedicine,YaleUniversitySchoolofMedicine,NewHaven,Connecticut(W.C.S.)AbstractThe90-kDaheatshockprotein(hsp90)regulatesthestabilityandfunctionofmanyclientproteins,i...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第4期MicrobialDNATypingbyAutomatedRepetitive-Sequence-BasedPCR
SpectralGenomics,Inc.DepartmentsofPathologyMolecularVirologyandMicrobiologyMolecularandHumanGeneticsPediatrics,BaylorCollegeofMedicineDepartmentsofPathologyPediatrics,TexasChildren‘sHospital,Houston,TexasDepartmentofPediatrics,WakeForestUniversitySchoolofMedicine,Winston-Salem,NorthCarolinaABSTRAC...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期Partialbladderoutletobstructionabolishesthereceptor-andGprotein-dependentincreaseincalciumsensitivityinrabbitbladdersmoothmuscle
...Ca2+]increasedforceinpermeabilizedstripsfromcontrolanimals;theadditionof10µMcarbacholand10µMGTPincreasedboththeCa2+sensitivityofthecontractionsandthemaximallevelsofforceattained.Incontrast,althoughincreasesin[Ca2+]increasedforceinpermeabilizedstripsfromPBOOanimals,theadditionofcarbachola...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第10期Ischemia-reperfusioninducesG-CSFgeneexpressionbyrenalmedullarythickascendinglimbcellsinvivoandinvitro
【摘要】Ischemicacuterenalfailureinvolvesnotonlythekidneybutalsoextrarenalorganssuchasthebonemarrowthatproducesinflammatorycells.ByELISAandRNaseprotectionassays,wenowshowthatrenalischemia-reperfusionincreasesserumconcentrationsofgranulocytemacrophagecolony-stimulatingfactor(G-CSF)proteinandincre...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第6期NuclearFactor-BpandStress-ActivatedProteinKinaseMitogen-ActivatedProteinKinaseSignalingPathwaysRegulateProinflammatoryCytokinesandApoptosisin
...reunknown,buttheyrepresentapotentialtargetfortherapeuticinterventions.Weexaminedactivationofsignalingpathwaysduringhypoxia-reoxygenationofvillousexplantsinvitro.Hypoxia-reoxygenationactivatedthep38andstress-activatedproteinkinasemitogen-activatedproteinkinase(MAPK)andthenuclearfactor-Bpathways.Downs...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期EpidermalGrowthFactorReceptorIsaCriticalMediatorofUltravioletBIrradiation-InducedSignalTransductioninImmortalizedHumanKeratinocyteHaCaTCell
...SkincancerarisingfromexposuretoultravioletBirradiation(UVB)fromthesunisaprominentformofhumancancer.Recentdataindicatethatinadditiontocognateligands,EGFRisactivatedbyUVBirradiation.WeusedpharmacologicalandgeneticapproachestoinvestigatethefunctionofEGFRinmediatingUVB-inducedsignaltransductioninhumansk...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期Treatmentfor2mowithn–3polyunsaturatedfattyacidsreducesadiposityandsomeatherogenicfactorsbutdoesnotimproveinsulinsensitivityinwomen
...ignard-Boulangé,HubertVidal,GérardSlama,KarineClément,MichèleGuerre-MilloandSalwaWRizkalla1FromINSERM,Nutriomique,U872(team7),Paris,France(NN,KC,MG-M,andSWR);AP-H,Hôtel-DieuHospital,DepartmentsofDiabetesandNutrition,Paris,France(MK,GS,VP,GS,KC,andSWR);UniversityPier...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第6期GeneticandEnvironmentalDeterminantsofFibrinStructureandFunction
FromtheAcademicUnitofMolecularVascularMedicine,FacultyofMedicineandHealth,UniversityofLeeds,Leeds,UK.ABSTRACTTheformationofafibrinclotisoneofthekeyeventsinatherothromboticvasculardisease.Thestructureofthefibrinclotandthegeneticandenvironmentalfactorsthatmodifyithaveeffectsonitsbiologicalfunction.Alt...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第9期