Changesinsubcellulardistributionoftheammoniatransporter,Rhcg,inresponsetochronicmetabolicacidosis
【摘要】Theprimarymechanismbywhichthekidneysmediatenetacidexcretionisthroughammoniametabolism.Inthecurrentstudy,weexaminedwhetherchronicmetabolicacidosis,whichincreasesammoniametabolism,altersthecell-specificand/orthesubcellularexpressionoftheammoniatransporterfamilymember,Rhcg,intheoutermedulla...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第6期AquaporinIsOverexpressedinLungCancerandStimulatesNIH-TCellProliferationandAnchorage-IndependentGrowth
...rmovement.Mosttumorshavebeenshowntoexhibithighvascularpermeabilityandinterstitialfluidpressure,butthetransportpathwaysforwaterwithintumorsremainunknown.Here,wetested10non-smallcelllungcancercelllinesofvariousoriginsbyreversetranscriptase-polymerasechainreactionandWesternblotanalysisandidentifiedclea...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期RenalHemodynamicInflammatoryandApoptoticResponsestoLipopolysaccharideinHO-C/CMice
...ponsetoLPS.InHO-1C/Cmice,ascomparedwithHO-1+/+mice,LPSprovokedagreaterreductioninglomerularfiltrationrateandrenalbloodflow,increasedrenalcytokineexpression,andincreasedactivationofnuclearfactor(NF)-B.Conversely,HO-1-overexpressingrenalepithelialcells,exposedtoLPS,exhibitedabluntedactivationofNF-Band...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期SalvicineFunctionsasNovelTopoisomeraseIIPoisonbyBindingtoATPPocket
...ineSalvicine,astructurallymodifiedditerpenoidquinonederivedfromSalviaprionitis,isanonintercalativetopoisomeraseII(topoII)poison.Thecompoundpossessespotentinvitroandinvivoantitumoractivitywithabroadspectrumofanti-multidrugresistanceactivityandiscurrentlyinphaseIIclinicaltrials.Toelucidatethedistincta...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期Adenovirus-MediatedExpressionofHumanParaoxonase3ProtectsAgainsttheProgressionofAtherosclerosisinApolipoproteinE–DeficientMice
【摘要】Objective—Wehavepreviouslyreportedthathumanparaoxonase3(PON3)isanHDL-associatedproteincapableofpreventingLDLoxidationinvitro.TheobjectiveofthepresentstudywastodeterminewhetherelevatedlevelsofhumanPON3inmicecouldprotectagainsttheprogressionofatherosclerosisinvivo.MethodsandResults&m...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第6期HumanPlacentalHypoxia-InducibleFactor-ExpressionCorrelateswithClinicalOutcomesinChronicHypoxiainVivo
【摘要】2700m;HA).Thenucleartranscriptionfactorhypoxia-induciblefactor(HIF)mayfacilitateplacentaloxygentransportatHAbyincreasingerythropoiesisandplacentalangiogenesis.WethereforeinvestigatedHIFexpressionanditsregulatorymechanismsinplacentasfromnormalpregnanciesathigh(3100m),moderate(1600m),andse...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期Intramuscularviraldeliveryofparapleginrescuesperipheralaxonopathyinamodelofhereditaryspasticparaplegia
1TelethonInstituteofGeneticsandMedicine(TIGEM),Naples,Italy.2DepartmentofNeurology,UniversityVita-Salute,SanRaffaeleScientificInstitute,Milan,Italy.AbstractDegenerationofperipheralmotoraxonsisacommonfeatureofseveraldebilitatingdiseasesincludingcomplicatedformsofhereditaryspasticparaplegia.Onesuchfor...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期EvidenceforHSP-mediatedcytoskeletalstabilizationinmesothelialcellsduringacuteexperimentalperitonealdialysis
【摘要】Lowbiocompatibilityofperitonealdialysisfluid(PDF)injuresmesothelialcellsandactivatestheirstressresponse.Inthisstudy,weinvestigatedtheroleofheatshockproteins(HSP),themaincytoprotectiveeffectorsofthestressresponse,incytoskeletalstabilizationofmesothelialcellsinexperimentalperitonealdialysi...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期SimvastatinReducesMMP1ExpressioninHumanSmoothMuscleCellsCulturedonPolymerizedCollagenbyInhibitingRac1Activation
【摘要】Objective-Activationofcollagenreceptorsexpressedbysmoothmusclecellsinducesmatrixmetalloproteinase(MMP)expression.The3-hydroxy-3-methylglutarylcoenzymeAreductaseinhibitors(statins)havebeenshowntointerferewithintegrinsignaling,buttheireffectsoncollagenreceptor-mediatedMMPexpressionhavenotb...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期IncreasedCholesterolDeposition,ExpressionofScavengerReceptors,andResponsetoChemotacticFactorsinAbca1-DeficientMacrophages
...EasternPointRd,Groton,CT06340.E-mailomar.l.francone@pfizer.comAbstractObjective—StudiesinbonemarrowtransplantedfromATP-bindingcassettetransporterA1(ABCA1)–deficientmiceintonormalmiceprovidesdirectevidencethattheabsenceofleukocyteABCA1exertsamarkedproatherogeniceffectindependentofchangesinplasmal...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第6期