ExpressionofICOSInVivoDefinesCD4+EffectorTCellswithHighInflammatoryPotentialandaStrongBiasforSecretionofInterleukin10
...cellsinthesecondarylymphoidorgansofnonmanipulatedmice,inthecontextofan“unbiased“immunesystemshapedbyenvironmentalantigens.Usingsinglecellanalysis,ICOSlowcellswerefoundtobelooselyassociatedwiththeearlycytokinesinterleukin(IL)-2,IL-3,IL-6,andinterferon(IFN)-.ICOSmediumcells,thelargemajorityofICOS+...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第2期ExpressionofICOSInVivoDefinesCD4+EffectorTCellswithHighInflammatoryPotentialandaStrongBiasforSecretionofInterleukin10
...cellsinthesecondarylymphoidorgansofnonmanipulatedmice,inthecontextofan“unbiased“immunesystemshapedbyenvironmentalantigens.Usingsinglecellanalysis,ICOSlowcellswerefoundtobelooselyassociatedwiththeearlycytokinesinterleukin(IL)-2,IL-3,IL-6,andinterferon(IFN)-.ICOSmediumcells,thelargemajorityofICOS+...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第2期MorphogenesisoftherightventriclerequiresmyocardialexpressionofGata4
1CardiovascularDivisionand2CenterforMatrixBiology,DepartmentofMedicine,BethIsraelDeaconessMedicalCenterandHarvardMedicalSchool,Boston,Massachusetts,USA.3DepartmentofCardiology,Children’sHospitalBoston,Boston,Massachusetts,USA.4DepartmentofPathology,HarvardMedicalSchool,Boston,Massachusetts,USA.5De...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期DefectivethrombusformationinmicelackingcoagulationfactorXII
1InstituteofClinicalBiochemistryandPathobiochemistry,DeutscheForschungsgemeinschaftResearchCenterforExperimentalBiomedicine,UniversityofWürzburg,97078Würzburg,Germany2RudolfVirchowCenter,DeutscheForschungsgemeinschaftResearchCenterforExperimentalBiomedicine,UniversityofWürzburg,97078Würzburg,Ger...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第2期心电QT间期与长期应用利培酮、喹硫平及代谢等的关系
...≥6.1mmol/L、餐后2h血糖≥7.8mmol/L或隐性糖尿病;e、收缩压/舒张压(SBP/DBP)≥130/85mmHg,和/或当前使用抗高血压药。④心电图QT间期,测量从Q波起始到T波终止的时间,因QT间期随心率而变化,常用校正QT间期(QTC)。QTC=QT/R-R2。R-R为...
医源资料库;在线期刊;中国民康医学;2009年第21卷第9期HepaticLipaseDeficiencyDelaysAtherosclerosis,MyocardialInfarction,andCardiacDysfunctionandExtendsLifespaninSR-BI/ApolipoproteinEDoubleKnockou
【摘要】Objective-SR-BI/apolipoprotein(apo)Edoubleknockout(dKO)miceexhibitmanyfeaturesofhumancoronaryheartdisease(CHD),includingocclusivecoronaryatherosclerosis,cardiachypertrophy,myocardialinfarctions,andprematuredeath.Herewedeterminedtheeffectsonthispathologyofhepaticlipase(HL)deficiency,which...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第3期AMP-activatedproteinkinasesignalinginmetabolicregulation
...Livingorganismsareconstantlychallengedwithirregularfoodsupply;thereforetheabilitytomaintainenergybalanceduringfooddeprivationiscriticalforsurvival.Suchselectionpressurehasdrivenorganismstoevolvecomplexsystemstostorefuelsubstratesduringfoodsupplyandtoreduceenergyexpenditureduringfoodshortage.Insulini...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期Thyrotropinreceptor–associateddiseases:fromadenomatatoGravesdisease
...ethyroiddisease,andsomeTSHRantibodiesmayactivatethereceptor,whileothersinhibititsactivationorhavenoinfluenceonsignaltransductionatall,dependingonhowtheyinfluencetheintegrityofthestructure.Clinicalassaysforsuchantibodieshaveimprovedsignificantlyandareausefuladditiontotheinvestigativearmamentarium.Fur...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期Regulationofthegerminalcentergeneprogrambyinterferon(IFN)regulatoryfactor8/IFNconsensussequence-bindingprotein
...oryofImmunopathology,NationalInstituteofAllergyandInfectiousDiseases,2BCellBiologyGroupandAutoimmunityBranch,NationalInstituteofArthritisandMusculoskeletalandSkinDiseases,3LaboratoryofMolecularGrowthRegulation,NationalInstituteofChildHealthandHumanDevelopment,NationalInstitutesofHealth,Bethesda,MD20...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期SystemiclupuserythematosusserumIgGincreasesCREMbindingtotheIL-2promoterandsuppressesIL-2productionthroughCaMKIV
...matosus(SLE)TcellsexpresshighlevelsofcAMPresponseelementmodulator(CREM)thatbindstotheIL-2promoterandrepressesthetranscriptionoftheIL-2gene.ThisstudywasdesignedtoidentifypathwaysthatleadtoincreasedbindingofCREMtotheIL-2promoterinSLETcells.Ca2+/calmodulin–dependentkinaseIV(CaMKIV)wasfoundtobeincreas...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期