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QuantitativeNucleicAcidSequence-BasedAssayasaNewMolecularToolforDetectionandQuantificationofLeishmaniaParasitesinSkinBiopsySamples
...urinameFundaodeMedicinaTropicaldoAmazonas,Manaus,BrazilBolanMedicalCollege,Quetta,PakistanABSTRACTCurrentlyavailablemethodsforthediagnosisofcutaneousleishmaniasis(CL)havelowsensitivitiesorareunabletoquantifythenumberofviableparasites.Thisconstitutesamajorobstacleforthediagnosisofthediseaseandforthes...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第11期 -
AsymptomaticAirwayHyperresponsivenessACuriosityoranOpportunitytoPreventAsthma?
...eetdePneumologiedel‘UniversitéLaval,HôpitalLaval,Sainte-Foy,Québec,Canada：Asymptomaticincreaseinairwayresponsetovariousstimulihasbeendescribedinepidemiologicstudies.Althoughitssignificanceisstilluncertain,insomesubjects,asymptomaticairwayhyperresponsiveness(AHR)maybemorethana...
医源资料库；在线期刊；美国呼吸和危急护理医学；2003年第167卷第3期 -
StructuralBasisforEpibatidineSelectivityatDesensitizedNicotinicReceptors
...106eC119,164eC171/166eC177,andPro190/Ala196.Pointmutationsrevealthatthreesequencedifferenceswithinthe104eC117/106eC119regionaredeterminantsofepibatidineselectivity:Lys104/Tyr106,Ser111/Tyr113,andTyr117/Tyr119.Inthe-subunit,simultaneousmutationoftheseresiduestotheirequivalentproduceshighaffinity,-lik...
医源资料库；在线期刊；分子药理学杂志；2005年第67卷第1期 -
SuppressionandRegressionofChoroidalNeovascularizationbySystemicAdministrationofan51IntegrinAntagonist
...inedwithDAPI(KirkegaardandPerryLaboratories,Gaithersburg,MD)andmountedwithAquamount(BritishDrugHouse,Poole,Dorset,UK).SerialsectionswerestainedwithbiotinylatedGriffoniasimplicifolialectinB4(GSA;VectorLaboratories)toidentifychoroidalneovascularizationasdescribedpreviously(Ozakietal.,1998).Inbrief,sli...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第6期 -
AlcoholdrinkingdeterminestheeffectoftheAPOElocusonLDL-cholesterolconcentrationsinmen:theFraminghamOffspringStudy
...omtheUSDepartmentofAgricultureAgriculturalResearchService.3AddressreprintrequeststoJMOrdovas,LipidMetabolismLaboratory,USDA,HNRCAatTuftsUniversity,711WashingtonStreet,Boston,MA02111.E-mail:ordovas{at}hnrc.tufts.edu.ABSTRACTBackground:TheeffectofalcoholdrinkingonLDL-cholesterolconcentrationsisunclear...
医源资料库；在线期刊；美国临床营养学杂志；2001年73卷第4期 -
FibrinogenandfibronectinbindingcooperateforvalveinfectionandinvasioninStaphylococcusaureusexperimentalendocarditis
...suedamageanddistantdiseases(1–4).Inaddition,infectionscausedbyS.aureusfrequentlyrelapseinspiteofadequateantibiotictreatment.Suchpersistenceoftenremainsunexplained.Onepossiblecausereliesontheirabilitytosurviveinsidehostcells.S.aureuscaninvadeavarietyofnonprofessionalphagocytesinvitro,suchasepitheli...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第10期 -
E2F2andE2F4butnotE2F1andE2F3InduceDNASynthesisinCardiomyocytesWithoutActivationofApoptosis
...xpressionofE2F5oracontrolLacZ-Adenovirushadnoeffectsoncellcycleprogression.QuantitativerealtimePCRrevealedthatE2F1,E2F2,E2F3,andE2F4alleviateG0arrestbyinductionofcyclinAandEcyclins.Furthermore,directedexpressionofE2F1,E2F3,andE2F5ledtoatranscriptionalactivationofseveralproapoptoticgenes,whichweremit...
医源资料库；在线期刊；循环研究杂志；2005年第95卷第3期 -
DistinctSignalingProfilesof1and2AdrenergicReceptorLigandstowardAdenylylCyclaseandMitogen-ActivatedProteinKinaseRevealsthePluridimensionalit
...ssuggestthatefficacymayalsobeinfluencedbythesignalingeffectorsengagedbyauniquereceptor.Todirectlyandsystematicallytestthispossibility,weassessedtheabilityofapanelof-adrenergicligandstomodulatetheactivityoftwoeffectorsystems,theadenylylcyclase(AC)andthemitogen-activatedproteinkinase(MAPK),via1and2adr...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第11期 -
MiceLackingNeutrophilElastaseAreResistanttoBleomycin-InducedPulmonaryFibrosis
...rlavagefluidandlungtissue.Thesedatapointtonovelandunexpectedfibrogenicconsequencesofneutrophilelastaseactivityintheinflamedlung.--------------------------------------------------------------------------------Pulmonaryfibrosisisthemostsevereadverseeffectassociatedwiththeclinicaluseofbleomycin,1acytot...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第1期 -
PropionibacteriumacnesTypesIandIIRepresentPhylogeneticallyDistinctGroups
DepartmentofMicrobiologyandImmunobiology,SchoolofMedicine,Queen‘sUniversity,Belfast,UnitedKingdomCorixaCorporation,InfectiousDiseaseResearchInstitute,Seattle,WashingtonABSTRACTAlthoughtwophenotypesoftheopportunisticpathogenPropionibacteriumacnes(typesIandII)havebeendescribed,epidemiologicalinvesti...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第1期