IL-1receptor–associatedkinaseMisacentralregulatorofosteoclastdifferentiationandactivation
...kereceptor;TRAF,TNFreceptor–associatedfactor.H.LiandE.Cuartascontributedequallytothiswork.Multinucleatedosteoclastsoriginatefromthefusionofmononuclearphagocytesandplayamajorroleintheresorptionofbone.Becauseosteoclastsareessentialforthedevelopmentandremodelingofbone,increasesintheirnumberand/oracti...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第7期VaccinationpreservesCD4memoryTcellsduringacutesimianimmunodeficiencyviruschallenge
...ftheCD4memorycompartmentduringtheacutephaseprovidesastrongpredictorforsubsequentprogressiontodeath.Ourdataprovideamechanismtoexplainclinicalobservationsthatacute-phaseviralloadspredictlong-termdiseaseprogressionandunderscoretheneedforinterventionsthatprotectagainstearlydestructionofCD4memoryTcellsdu...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第6期半夏配方颗粒的制备工艺和含量测定*
【摘要】目的确定半夏配方颗粒的最佳提取工艺,建立半夏配方颗粒中总生物碱的含量测定方法。方法设计L9(34)正交试验确定最佳水提工艺;紫外分光光度法测定总生物碱含量。结果最佳提取工艺:8倍量水,微沸回流1.5h,回...
医源资料库;在线期刊;中华实用医药杂志;2007年第7卷第3期AllostericInteractionsRequiredforHigh-AffinityBindingofDihydropyridineAntagoniststoCaV1.1ChannelsAreModulatedbyCalciuminthePore
【关键词】AllostericInteractionsRequiredDihydropyridines(DHPs)areanimportantclassofdrugs,usedextensivelyinthetreatmentofanginapectoris,hypertension,andarrhythmia.ThemolecularmechanismbywhichDHPsmodulateCa2+channelfunctionisnotknownindetail.WehavefoundthatDHPbindingisallostericallycoupledtoCa2+b...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期RegulationofLymphocyteApoptosisbyInterferonRegulatoryFactor4(IRF-4)
...ofFasandinthetransmissionofastrongdeathsignal(4).Transductionofthissignalrequirestheassemblyofadeath-inducingsignalingcomplex(DISC),whichinvolvestherecruitmentoftheFas-associateddeathdomain(FADD)adaptorproteinandofcaspase-8,acriticalinitiatorcaspasetothecytoplasmicportionoftheFasreceptor(5).Interact...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期AssociationofTumorNecrosisFactora-2anda-8MicrosatelliteAlleleswithHumanPapillomavirusandSquamousIntraepithelialLesionsamongWomeninBrazil
...dtheassociationsbetweenTNFato-emicrosatellitepolymorphismsandtheseverityofsquamousintraepitheliallesions(SIL),accordingtothepresenceoftheoncogenicHPV16andHPV18types.Samplesfrom146HPV-positivewomenwithlow-gradeSIL(LSIL)andhigh-gradeSIL(HSIL)andsamplesfrom101healthywomenwerestudied.TNFmicrosatellitepo...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期ControlledClinicalComparisonofPlasticversusGlassBottlesofBacT/ALERTPFMediumforCulturingBloodfromChildren
...obtainedover95%ofthetime.Accordingtoinstructionswitheachbloodculturekit,aliquotsofbloodobtainedbyvenipunctureweretobedistributedequallybetweentheglassPFandplasticPPFaerobicbottles.Eachbottlewasweighedbeforeinoculationanduponreceiptinthelaboratory.Ifthetotalvolumeofbloodwasgreaterthan5ml,bloodvolumes...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期CD127expressioninverselycorrelateswithFoxP3andsuppressivefunctionofhumanCD4+Tregcells
...hetranscriptionfactor,FoxP3.However,thesemarkershaveprovenproblematicforuniquelydefiningthisspecializedTcellsubsetinhumans.WefoundthattheIL-7receptor(CD127)isdown-regulatedonasubsetofCD4+Tcellsinperipheralblood.WedemonstratethatthemajorityofthesecellsareFoxP3+,includingthosethatexpresslowlevelsornoC...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期IntakeoffriedfoodsisassociatedwithobesityinthecohortofSpanishadultsfromtheEuropeanProspectiveInvestigationintoCancerandNutrition
...arAmianoEtxezarreta,EvaArdanaz,AurelioBarricarte,María-DoloresChirlaque,MirenDorronsoroIraeta,NereaLarrañagaLarrañaga,AdaminaLosada,MichelleMendez,CarmenMartínez,JoséRQuirós,CarmenNavarro,PaulaJakszyn,MaríaJSánchez,MaríaJTormoandCarlosAG...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第1期CannabinoidReceptor-MediatedApoptosisInducedbyR(+)-MethanandamideandWin55,212-2IsAssociatedwithCeramideAccumulationandp38ActivationinMantleC
...concurrentligationofCB1andCB2witheitherR(+)-MAorWin55inducesapoptosisviaasequenceofeventsinMCLcells:accumulationofceramide,phosphorylationofp38,depolarizationofthemitochondrialmembrane,andcaspaseactivation.AlthoughinductionofapoptosiswasobservedinbothMCLcelllinesandprimaryMCL,normalBcellsremaineduna...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期