快速增长的生长激素市场—强者恒强
...比增38.9%。公司目前仅有粉针剂竞争较为激烈,公司正努力补齐产品线:其水剂产品申报生产注册获得受理,长效化技术平台是公司发展重点:PEG化生长激素于2011年10月获临床批件,正进行2期临床试验。PEG化重组人干扰素α2b注射液获临...
医药经济;生物技术;技术要闻ShiftsofBordetellapertussisVariantsinSwedenfrom1970to2003,duringThreePeriodsMarkedbyDifferentVaccinationPrograms
SwedishInstituteforInfectiousDiseaseControl,SE-17182Solna,SwedenABSTRACTTheSwedishpopulationofBordetellapertussisstrainswascharacterizedfrom1,247isolatescoveringawhole-cellvaccineprogramupto1979,a17-yearperiodwithoutvaccination(1979to1996),andaperiodaftertheintroductionofgeneralvaccinationamongnewbo...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期L-精氨酸对局灶性脑缺血损伤大鼠脑组织TNF-α、IL-1β及神经元凋亡的影响
...SD大鼠30只,体重250~280g,随机分为3组(n=10):假手术组(SH组)、缺血组(IS组)和L-广精氨酸治疗组(L-arg组)。L-arg组腹腔注射L-精氨酸500mg/kg,每日2次,连续3d;IS组给予等容量的生理盐水;2组均采用线栓法制备大鼠局灶性脑缺血损...
行业资讯;临床快报;神经科第三节 膜受体介导的信号转导
...一步增强。此外更重要的是,磷酸化的受体可以慕集含有SH2结构域(见后)的信号分子,从而将信号传递至下游分子。 B.位于胞浆部分的蛋白酪氨酸激酶 胞浆内亦含有多种PTKs,这些蛋白激酶或接受受体传递的激活信号,或...
医源资料库;医源图书馆;教材类;生物化学与分子生物学Race-ethnicitydifferencesinfolicacidintakeinwomenofchildbearingageintheUnitedStatesafterfolicacidfortification:findingsfromtheNationalH
Quan-HeYang,HeatherKCarter,JosephMulinare,RJBerry,JMFriedmanandJDavidErickson1FromtheDivisionofBirthDefectsandDevelopmentalDisabilities,NationalCenteronBirthDefectsandDevelopmentalDisabilities,CentersforDiseaseControlandPrevention,Atlanta,GA(Q-HY,HKC,JM,RJB,andJDE),andtheDepartmentofMedicalGenetics,...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第5期C1q-DeficiencyIsNeuroprotectiveAgainstHypoxic-IschemicBrainInjuryinNeonatalMice
...emicbraininjuryinneonatalmice.Methods—Hypoxia-ischemia(HI)wasproducedinC1q–/–andwild-type(WT)neonatalmice.At24hoursafterHI,neonatalmousereflexperformanceandcerebralinfarctvolumewereassessed.Long-termoutcomesweremeasuredbywater-mazeperformanceanddegreeofcerebralatrophyat7to8weeksafterHI.Activat...
医源资料库;在线期刊;中风学杂志;2005年第36卷第10期ThePimkinasescontrolrapamycin-resistantTcellsurvivalandactivation
...seofPim-1–/–Pim-2–/–cells.Thus,endogenouslevelsofthePimkinasesarerequiredforTcellstomountanimmuneresponseinthepresenceofrapamycin.Theexistenceofarapamycin-insensitivepathwaythatregulatesTcellgrowthandsurvivalhasimportantimplicationsforunderstandinghowrapamycinfunctionsasanimmunomodulatorydru...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第2期ChroniclymphocyticleukemiacellsinducechangesingeneexpressionofCD4andCD8Tcells
...Bcellchroniclymphocyticleukemia(CLL),anumberofwell-characterizedTcelldefectshavebeendescribed,anditismostlikelythatimmunosuppressioninducedbythemalignantBcellsplaysanimportantroleintheinductionofsubsequentimmunedeficiencyinthisdisease.CLLcellsexpresshighlevelsofimmunomodulatoryfactorsincludingTGF-?a...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期高效液相色谱法测定心达康片的含量
...hecontentoftotalflavanoidsinXindakangtabaletsbyRP-HPLC.MethodsThecontentsofquercetin,kaempferolandisofhamnetinweredeterminedbyHPLCsimultaneously.C18column(250×4.6mm,5μm)wasusedwiththemixtureofCH3OH-0.2%phosphate(45∶55)(pH2.27)asthemobilephaseataflowrateof1.0mL·min-1withthedetectionwavel...
药品天地;专业药学;实验技术;色谱技术;色谱论文N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide(ICA-27243):ANovel,SelectiveKCNQ2/Q3PotassiumChannelActivator
...(ICA-27243)asaselectiveactivatoroftheneuronalMcurrentandKCNQ2/Q3channels.InSH-SY5Yhumanneuroblastomacells,ICA-27243producedmembranepotentialhyperpolarizationthatcouldbepreventedbycoadministrationwiththeM-currentinhibitors10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenonedihydrochloride(XE-991)andlinop...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期